公开(公告)号：US20180274033A1

公开(公告)日：2018-09-27

申请号：US15928939

申请日：2018-03-22

申请人： Mariano A. Garcia-Blanco ,  Gaddiel Galarza-Munoz ,  Simon G. Gregory ,  Farren B.S. Briggs ,  Lisa F. Barcellos ,  Shelton S. Bradrick ,  Irina Evsyukova ,  Dennis C. Ko

发明人： Mariano A. Garcia-Blanco ,  Gaddiel Galarza-Munoz ,  Simon G. Gregory ,  Farren B.S. Briggs ,  Lisa F. Barcellos ,  Shelton S. Bradrick ,  Irina Evsyukova ,  Dennis C. Ko

IPC分类号： C12Q1/6883 ,  C12Q1/34 ,  C12Q1/6806

CPC分类号： C12Q1/6883 ,  C12Q1/34 ,  C12Q1/6806 ,  C12Q1/683 ,  C12Q1/6851 ,  C12Q1/686 ,  C12Q2600/156 ,  C12Y306/04013

摘要： The present invention includes a method, kits, and assays for identifying a human subject as having an increased risk of developing an autoimmune disease, or a human subject with multiple sclerosis caused by elevated soluble Interleukin 7 receptor (sIL7R), by obtaining a biological sample and detecting or measuring in the biological sample an amount of a soluble Interleukin-7 receptor (sIL7R) and an amount of an RNA Helicase DDX39B, whereby a lower expression of DDX39B and a higher secretion of sIL7R identifies the subject from which the biological sample was obtained as having an increased risk of developing an autoimmune disease, when compared to a human subject not having an autoimmune disease. The present invention also includes a method of modifying a treating of subjects based on the lower expression of RNA Helicase DDX39B alone or in combination with an increase in sIL7R.