公开(公告)号：US20110178013A1

公开(公告)日：2011-07-21

申请号：US13121928

申请日：2009-09-29

申请人： Marie-Thérèse Paternostre ,  Jean-Christophe Cintrat ,  Céline Valery ,  Stéphane Roux ,  Bernard Rousseau ,  Maarten Ijsselstijn ,  Roland Cherif-Cheikh ,  Frank Artzner

发明人： Marie-Thérèse Paternostre ,  Jean-Christophe Cintrat ,  Céline Valery ,  Stéphane Roux ,  Bernard Rousseau ,  Maarten Ijsselstijn ,  Roland Cherif-Cheikh ,  Frank Artzner

IPC分类号： A61K38/12 ,  C07K7/54 ,  A61P3/10 ,  A61P19/00 ,  A61P17/00

CPC分类号： C07K14/665 ,  A61K38/00

摘要： The present invention relates to novel octapeptide compounds of general formula (I): H-2-Nal1-cyclo(Cys2-Tyr3-AA4-Lys5-Val6-Cys7)-Thr8-NH2. Since these products have a good affinity for certain somatostatin receptor subtypes, they are particularly advantageous for treating pathological states or diseases in which one (or more) somatostatin receptor(s) is (are) involved. These compounds furthermore have physiochemical properties that make it possible to envisage them in diverse solutions for the formulation of medicaments, for example as a pharmaceutically acceptable carrier. The invention also relates to pharmaceutical compositions containing said products and to the use thereof for the preparation of a medicament.

摘要翻译： 本发明涉及通式（I）的新型八肽化合物：H-2-Nal1-环（Cys2-Tyr3-AA4-Lys5-Val6-Cys7）-Thr8-NH2。 由于这些产品对某些生长抑素受体亚型具有良好的亲和力，因此它们特别有利于治疗涉及一种（或更多种）生长抑素受体的病理状态或疾病。 这些化合物还具有物理化学性质，使得可以将它们设想为药物制剂的各种溶液，例如药学上可接受的载体。 本发明还涉及含有所述产物的药物组合物及其用于制备药物的用途。

公开(公告)号：US09382306B2

公开(公告)日：2016-07-05

申请号：US13121928

申请日：2009-09-29

申请人： Marie-Thérèse Paternostre ,  Jean-Christophe Cintrat ,  Céline Valery ,  Stéphane Roux ,  Bernard Rousseau ,  Maarten Ijsselstijn ,  Roland Cherif-Cheikh ,  Franck Artzner

发明人： Marie-Thérèse Paternostre ,  Jean-Christophe Cintrat ,  Céline Valery ,  Stéphane Roux ,  Bernard Rousseau ,  Maarten Ijsselstijn ,  Roland Cherif-Cheikh ,  Franck Artzner

IPC分类号： A61K38/31 ,  A61P5/02 ,  C07K14/655 ,  A61K38/12 ,  C07K5/00 ,  C07K7/00 ,  C07K16/00 ,  C07K17/00 ,  C07K14/665 ,  A61K38/00

CPC分类号： C07K14/665 ,  A61K38/00

摘要： The present invention relates to novel octapeptide compounds of general formula (I): H-2-Nal 1-cyclo(Cys2-Tyr3-AA4-Lys5-Val6-Cys7)-Thr8-NH2. Since these products have a good affinity for certain somatostatin receptor subtypes, they are particularly advantageous for treating pathological states or diseases in which one (or more) somatostatin receptor(s) is (are) involved. These compounds furthermore have physiochemical properties that make it possible to envisage them in diverse solutions for the formulation of medicaments, for example as a pharmaceutically acceptable carrier. The invention also relates to pharmaceutical compositions containing said products and to the use thereof for the preparation of a medicament.

摘要翻译： 本发明涉及通式（I）的新型八肽化合物：H-2-萘-1-环（Cys2-Tyr3-AA4-Lys5-Val6-Cys7）-Thr8-NH2。 由于这些产品对某些生长抑素受体亚型具有良好的亲和力，因此它们特别有利于治疗涉及一种（或更多种）生长抑素受体的病理状态或疾病。 这些化合物还具有物理化学性质，使得可以将它们设想为药物制剂的各种溶液，例如药学上可接受的载体。 本发明还涉及含有所述产物的药物组合物及其用于制备药物的用途。

公开(公告)号：US20130252892A1

公开(公告)日：2013-09-26

申请号：US13806510

申请日：2011-06-21

申请人： Jean-Christophe Cintrat ,  Melinda Ligeti ,  Bernard Rousseau ,  Franck Artzner ,  Christophe Tarabout ,  Marie-Thérèse Paternostre ,  Nicolas Fay ,  Roland Cherif-Cheikh ,  Céline Valery

发明人： Jean-Christophe Cintrat ,  Melinda Ligeti ,  Bernard Rousseau ,  Franck Artzner ,  Christophe Tarabout ,  Marie-Thérèse Paternostre ,  Nicolas Fay ,  Roland Cherif-Cheikh ,  Céline Valery

IPC分类号： C07K7/54

CPC分类号： C07K7/54 ,  A61K38/00 ,  C07K14/655 ,  C07K14/6555

摘要： The present invention relates to novel octapeptide compounds of general formula (I), R-AA1-cyclo(AA2-Tyr3-D-Trp4-AA5-Val6-Cys7)-Thr8-NH2  (I) As these products have a good affinity for certain sub-types of somatostatin receptors, they are particularly useful for treating the pathological states or diseases in which one (or more) of the somatostatin receptors is (are) involved. The invention also relates to pharmaceutical compositions containing said products and their use for the preparation of a medicament.

摘要翻译： 本发明涉及通式（I）的新型八肽化合物，R-AA1-环（AA2-Tyr3-D-Trp4-AA5-Val6-Cys7）-Thr8-NH2（Ⅰ），因为这些产物对 某些亚型生长抑素受体，它们特别适用于治疗涉及生长抑素受体的一种（或多种）的病理状态或疾病。 本发明还涉及含有所述产品的药物组合物及其用于制备药物的用途。

公开(公告)号：US09040482B2

公开(公告)日：2015-05-26

申请号：US13806510

申请日：2011-06-21

申请人： Jean-Christophe Cintrat ,  Melinda Ligeti ,  Bernard Rousseau ,  Franck Artzner ,  Christophe Tarabout ,  Marie-Thérèse Paternostre ,  Nicolas Fay ,  Roland Cherif-Cheikh ,  Céline Valery

发明人： Jean-Christophe Cintrat ,  Melinda Ligeti ,  Bernard Rousseau ,  Franck Artzner ,  Christophe Tarabout ,  Marie-Thérèse Paternostre ,  Nicolas Fay ,  Roland Cherif-Cheikh ,  Céline Valery

IPC分类号： C07K14/655 ,  A61K38/31 ,  A61P5/02 ,  C07K7/54 ,  A61K38/00

CPC分类号： C07K7/54 ,  A61K38/00 ,  C07K14/655 ,  C07K14/6555

摘要： The present invention relates to novel octapeptide compounds of general formula (I), R-AA1-cyclo(AA2-Tyr3-D-Trp4-AA5-Val6-Cys7)-Thr8-NH2  (I) As these products have a good affinity for certain sub-types of somatostatin receptors, they are particularly useful for treating the pathological states or diseases in which one (or more) of the somatostatin receptors is (are) involved. The invention also relates to pharmaceutical compositions containing said products and their use for the preparation of a medicament.

摘要翻译： 本发明涉及通式（I）的新型八肽化合物，R-AA1-环（AA2-Tyr3-D-Trp4-AA5-Val6-Cys7）-Thr8-NH2（Ⅰ），因为这些产物对 某些亚型生长抑素受体，它们特别适用于治疗涉及生长抑素受体的一种（或多种）的病理状态或疾病。 本发明还涉及含有所述产品的药物组合物及其用于制备药物的用途。