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1.发明申请公开(公告)号：US20060211909A1
公开(公告)日：2006-09-21
申请号：US11302322
申请日：2005-12-14
IPC分类号： A61M1/12
CPC分类号： A61M1/1086 , A61F2/2481 , A61M1/1008 , A61M1/106 , A61M1/1068 , A61M1/12 , A61M1/127 , A61M2205/32 , A61M2205/33 , A61M2205/3303 , A61M2205/3331 , A61M2205/3334 , A61M2230/04 , A61M2230/202 , A61M2230/205 , A61N1/05
摘要： A process for assisting the function of a heart disposed within a body, comprising the steps of supporting the heart in providing circulation of blood for perfusion of an organ in the body, remodeling the heart to render the heart in an improved state, and stabilizing the heart in the improved state. The process is preferably performed with an apparatus comprising a cup-shaped shell having an exterior surface and an interior surface; a liner having an outer surface, an upper edge joined to said interior surface of said cup-shaped shell, and a lower edge joined of said interior surface of said cup-shaped shell, thereby forming a cavity between said outer surface thereof and said interior surface of said shell; a drive fluid cyclically interposed within said cavity; and at least one sensor measuring at least one macroscopic parameter indicative of said function of said heart. Further embodiments of the process and apparatus include means and use thereof for delivering a therapeutic agent to the heart.
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2.发明申请Method and apparatus for direct mechanical ventricular actuation with favorable conditioning and minimal heart stress 审中-公开用于直接机械心室致动的方法和装置，具有有利的调理和最小的心脏应力公开(公告)号：US20060167334A1
公开(公告)日：2006-07-27
申请号：US10795098
申请日：2004-03-05
IPC分类号： A61N1/362
CPC分类号： A61N1/0587 , A61M1/106 , A61M1/1068 , A61M1/1086 , A61M1/12 , A61M1/122 , A61M2205/33 , A61M2205/3303 , A61N1/0597 , A61N1/3627 , A61N1/3684
摘要： A process for assisting the function of a heart disposed within a body, comprising the steps of supporting the heart in providing circulation of blood for perfusion of an organ in the body, remodeling the heart to render the heart in an improved state, and stabilizing the heart in the improved state. The process is preferably performed with an apparatus comprising a cup-shaped shell having an exterior surface and an interior surface; a liner having an outer surface, an upper edge joined to said interior surface of said cup-shaped shell, and a lower edge joined of said interior surface of said cup-shaped shell, thereby forming a cavity between said outer surface thereof and said interior surface of said shell; a drive fluid cyclically interposed within said cavity; and at least one sensor measuring at least one macroscopic parameter indicative of said function of said heart. Further embodiments of the process and apparatus include means and use thereof for delivering a therapeutic agent to the heart.
摘要翻译： 一种用于辅助设置在体内的心脏的功能的过程，包括以下步骤：支撑心脏以提供血液循环以灌注身体中的器官，重塑心脏以使心脏处于改善的状态，并稳定 心脏在改善状态。 该方法优选用包括具有外表面和内表面的杯形壳体的装置进行; 具有外表面的衬套，与所述杯状壳体的所述内表面相连的上边缘以及所述杯形壳体的所述内表面连接的下边缘，从而在其外表面和所述内部空间之间形成空腔 所述外壳的表面; 循环地插入所述空腔内的驱动流体; 以及至少一个传感器，其测量指示所述心脏的所述功能的至少一个宏观参数。 该方法和装置的其它实施方案包括将治疗剂递送至心脏的手段和用途。
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3.发明申请Therapeutic agent delivery apparatus with direct mechanical ventricular assistance capability 审中-公开具有直接机械性心室辅助能力的治疗剂递送装置公开(公告)号：US20050234289A1
公开(公告)日：2005-10-20
申请号：US11143542
申请日：2005-06-02
IPC分类号： A61F20060101 , A61F2/00 , A61M1/10 , A61N1/05 , A61N1/362
CPC分类号： A61M1/1086 , A61F2/2481 , A61M1/1008 , A61M1/106 , A61M1/1068 , A61M1/12 , A61M1/127 , A61M2205/32 , A61M2205/33 , A61M2205/3303 , A61M2205/3331 , A61M2205/3334 , A61M2230/04 , A61M2230/202 , A61M2230/205 , A61N1/05
摘要： A therapeutic apparatus for delivering at least one therapeutic agent directly and preferentially to a desired tissue to be treated, comprising at least one membrane adapted to deliver the therapeutic agent to the desired tissue, wherein the membrane is in contact with at least a part of the desired tissue to be treated; and at least one shell surrounding the membrane, wherein the shell isolates the membrane from tissues other than the desired tissue to be treated. In one embodiment, the apparatus is a direct mechanical ventricular assistance apparatus comprising a liner in which the membrane is formed.
摘要翻译： 一种治疗装置，用于将至少一种治疗剂直接和优先地递送到期望的待治疗组织，包括至少一种适于将治疗剂递送至所需组织的膜，其中所述膜与至少一部分 所要治疗的组织; 以及围绕膜的至少一个外壳，其中所述外壳将所述膜与所述待治疗的所需组织以外的组织隔离。 在一个实施例中，该装置是包括形成膜的衬垫的直接机械性心室辅助装置。
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4.发明申请Sensor-equipped and algorithm controlled direct mechanical ventricular assist device 审中-公开传感器配备和算法控制的直接机械心室辅助装置公开(公告)号：US20060142634A1
公开(公告)日：2006-06-29
申请号：US11359542
申请日：2006-02-23
IPC分类号： A61M1/10
CPC分类号： A61M1/1086 , A61F2/2481 , A61M1/1008 , A61M1/106 , A61M1/1068 , A61M1/12 , A61M1/127 , A61M2205/32 , A61M2205/33 , A61M2205/3303 , A61M2205/3331 , A61M2205/3334 , A61M2230/04 , A61M2230/202 , A61M2230/205 , A61N1/05
摘要： An apparatus for assisting the function of a heart disposed within a body. The apparatus can apply a compressive force and an expansive force to a portion of the outer wall of the heart. The apparatus can comprise a cup-shaped shell having an exterior wall, an interior wall, an apex, and an upper edge; a liner having an outer surface and an inner surface, an upper edge joined to the interior wall of the cup-shaped shell, and a lower edge joined to the interior wall of the cup-shaped shell, thereby forming a cavity between the outer surface thereof and the interior wall of the shell; and a drive fluid within the cavity. The drive fluid can apply a force on a portion of the outer wall of the heart.
摘要翻译： 一种用于辅助设置在体内的心脏的功能的装置。 该装置可以对心脏外壁的一部分施加压缩力和膨胀力。 该装置可以包括具有外壁，内壁，顶点和上边缘的杯形外壳; 具有外表面和内表面的衬套，与杯状壳体的内壁连接的上边缘，以及连接到杯形壳体的内壁的下边缘，从而在外表面 和壳体的内壁; 以及腔内的驱动流体。 驱动流体可以在心脏的外壁的一部分上施加力。
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