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公开(公告)号：US4549951A
公开(公告)日：1985-10-29
申请号：US649434
申请日：1984-09-11
IPC分类号： G01N27/333 , G01N27/46
CPC分类号： G01N27/3335
摘要： An ion selective electrode includes a conductive electrode body which is supported by an insulating substrate. A convex dome-shaped membrane containing an electroactive species is deposited over and is directly in contact with the electrode body and a surface of the substrate surrounding the electrode body. The membrane has its greatest height above the electrode body and slopes down to meet the surface of the substrate. A moat formed in the insulating substrate surrounds the space from the electrode body to define the outer boundary of the dome-shaped member.
摘要翻译： 离子选择电极包括由绝缘基板支撑的导电电极体。 包含电活性物质的凸圆顶形膜被沉积在电极体上并直接与电极体和包围电极体的基底的表面接触。 该膜在电极体上方具有最大的高度，并且向下倾斜以与基底的表面相遇。 形成在绝缘基板中的护城河围绕电极体的空间，以限定圆顶状构件的外边界。
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公开(公告)号：USD288478S
公开(公告)日：1987-02-24
申请号：US622983
申请日：1984-06-21
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公开(公告)号：USD292229S
公开(公告)日：1987-10-06
申请号：US622987
申请日：1984-06-21
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4.发明授权Transdermal systems for the delivery of therapeutic agents including granisetron using iontophoresis 有权用于使用离子电渗法递送治疗剂（包括格拉司琼）的透皮系统公开(公告)号：US07856263B2
公开(公告)日：2010-12-21
申请号：US11112196
申请日：2005-04-22
CPC分类号： A61N1/30 , A61M2037/0007 , A61N1/0428 , A61N1/044
摘要： A disposable skin-worn device for the transdermal delivery at least one dose of charged therapeutic substances, including granisetron, by iontophoresis, the device comprising a donor reservoir containing an amount of a therapeutic substance to be delivered transdermally by iontophoresis, a counter reservoir, a source of electric power connected in a circuit between the donor reservoir and the counter reservoir and a control system for controlling current flow in the circuit to enable at least one dose of the therapeutic substance to be delivered transdermally by iontophoresis and wherein the control system includes a control element selected from the group consisting of a sensor activated by an external signal and a switch.
摘要翻译： 一种一次性皮肤佩戴的装置，用于透皮输送至少一个剂量的带电治疗物质，包括格拉司琼，通过离子电渗疗法，该装置包括供体储存器，该供体储存器含有通过离子电渗法透皮递送的治疗物质的量， 供电源连接在供体储存器和反向储存器之间的电路中，以及控制系统，用于控制电路中的电流流动，以使得至少一个剂量的治疗物质能够通过离子电渗疗法经皮递送，并且其中控制系统包括 从由外部信号激活的传感器和开关组成的组中选择的控制元件。
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5.发明授权Transdermal systems for the delivery of therapeutic agents including granisetron using iontophoresis 有权用于使用离子电渗法递送治疗剂（包括格拉司琼）的透皮系统公开(公告)号：US08463373B2
公开(公告)日：2013-06-11
申请号：US12955043
申请日：2010-11-29
CPC分类号： A61N1/30 , A61M2037/0007 , A61N1/0428 , A61N1/044
摘要： A disposable skin-worn device for the transdermal delivery at least one dose of charged therapeutic substances, including granisetron, by iontophoresis, the device comprising a donor reservoir containing an amount of a therapeutic substance to be delivered transdermally by iontophoresis, a counter reservoir, a source of electric power connected in a circuit between the donor reservoir and the counter reservoir and a control system for controlling current flow in the circuit to enable at least one dose of the therapeutic substance to be delivered transdermally by iontophoresis and wherein the control system includes a control element selected from the group consisting of a sensor activated by an external signal and a switch.
摘要翻译： 一种一次性皮肤佩戴的装置，用于透皮输送至少一个剂量的带电治疗物质，包括格拉司琼，通过离子电渗疗法，该装置包括供体储存器，该供体储存器含有通过离子电渗法透皮递送的治疗物质的量， 供电源连接在供体储存器和反向储存器之间的电路中，以及控制系统，用于控制电路中的电流流动，以使得至少一个剂量的治疗物质能够通过离子电渗疗法经皮递送，并且其中控制系统包括 从由外部信号激活的传感器和开关组成的组中选择的控制元件。
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6.发明授权
公开(公告)号：US5036861A
公开(公告)日：1991-08-06
申请号：US463387
申请日：1990-01-11
CPC分类号： G01N33/66 , A61B5/14521 , A61B5/14532 , A61B5/4266 , A61N1/325
摘要： A method and apparatus non-invasively monitor plasma constituent levels. A localized, modified sweating response is induced providing a sweat secretion for analysis of the plasma constituents.
摘要翻译： 一种方法和装置非侵入性地监测血浆成分水平。 诱发局部的，改良的出汗反应，提供用于分析血浆成分的汗液分泌。
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7.发明申请Transdermal Systems for the Delivery of Therapeutic Agents Including Granisetron Using Iontophoresis 有权用于使用离子电渗法包括格拉司琼的治疗剂递送的透皮系统公开(公告)号：US20110087154A1
公开(公告)日：2011-04-14
申请号：US12955043
申请日：2010-11-29
IPC分类号： A61N1/30
CPC分类号： A61N1/30 , A61M2037/0007 , A61N1/0428 , A61N1/044
摘要： A disposable skin-worn device for the transdermal delivery at least one dose of charged therapeutic substances, including granisetron, by iontophoresis, the device comprising a donor reservoir containing an amount of a therapeutic substance to be delivered transdermally by iontophoresis, a counter reservoir, a source of electric power connected in a circuit between the donor reservoir and the counter reservoir and a control system for controlling current flow in the circuit to enable at least one dose of the therapeutic substance to be delivered transdermally by iontophoresis and wherein the control system includes a control element selected from the group consisting of a sensor activated by an external signal and a switch.
摘要翻译： 一种一次性皮肤佩戴的装置，用于透皮输送至少一个剂量的带电治疗物质，包括格拉司琼，通过离子电渗疗法，该装置包括供体储存器，该供体储存器含有通过离子电渗法透皮递送的治疗物质的量， 供电源连接在供体储存器和反向储存器之间的电路中，以及控制系统，用于控制电路中的电流流动，以使得至少一个剂量的治疗物质能够通过离子电渗疗法经皮递送，并且其中控制系统包括 从由外部信号激活的传感器和开关组成的组中选择的控制元件。
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公开(公告)号：US07031768B2
公开(公告)日：2006-04-18
申请号：US10166157
申请日：2002-06-10
IPC分类号： A61N1/30
CPC分类号： A61N1/0436 , A61N1/044 , A61N1/0448
摘要： A planar disposable transdermal iontophoretic delivery system is disclosed which includes amounts of an oxidizable species and a reducible species connected by a common conductor forming a galvanic battery for serving as the sole source of power and control for the system, an amount of a therapeutic agent is provided to be driven through the skin of a patient solely through the use of the galvanic battery. The galvanic battery is provided with a lot-tested coulombic capacity rating to predict dosage.
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公开(公告)号：USD351910S
公开(公告)日：1994-10-25
申请号：US5165
申请日：1993-02-25
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