公开(公告)号：US20200093884A1

公开(公告)日：2020-03-26

申请号：US16576940

申请日：2019-09-20

申请人： Mark C. MANNING ,  Ryan E. Holcomb ,  Derrick S. Katayama ,  Christopher Bryant

发明人： Mark C. MANNING ,  Ryan E. Holcomb ,  Derrick S. Katayama ,  Christopher Bryant

IPC分类号： A61K38/095 ,  A61K47/38 ,  A61K9/08 ,  A61K9/00 ,  A61K47/55

摘要： The application describes stable aqueous compositions comprising relatively high concentrations of carbetocin and a solubilizer and/or surface active agent. The disclosed carbetocin compositions are effective in the treatment of a neurodevelopmental disorder, such as Präder-Willi syndrome. Additionally, the disclosed carbetocin compositions show improved stability at room temperature and/or under accelerated conditions of stress.

公开(公告)号：US20200093885A1

公开(公告)日：2020-03-26

申请号：US16576961

申请日：2019-09-20

申请人： Christopher BRYANT ,  Mark C. Manning ,  Ryan E. Holcomb

发明人： Christopher BRYANT ,  Mark C. Manning ,  Ryan E. Holcomb

IPC分类号： A61K38/095 ,  A61K47/38 ,  A61K9/08 ,  A61K47/22 ,  A61K47/26

摘要： The present disclosure includes a method of making an improved carbetocin drug product. The disclosed method for making an improved carbetocin drug product comprises agitating a carbetocin preparation containing an aqueous solution of carbetocin and one or more excipients for a period of time to initiate the formation of aggregate-forming solids and filtering off the aggregates that form before further processing the remaining carbetocin into a final drug product. The present disclosure also relates to an improved carbetocin drug product, wherein the drug product is substantially free of aggregate-forming solids. The disclosed carbetocin drug product can be used for the treatment of a neurodevelopmental disorder, such as Präder-Willi syndrome. Additionally, the disclosed carbetocin drug product shows content uniformity of carbetocin over long periods of time before and after one or more freeze/thaw cycles, provides enhanced convenience and patient compliance, and/or are highly concentrated.

公开(公告)号：US10024797B2

公开(公告)日：2018-07-17

申请号：US13988723

申请日：2011-11-22

申请人： Kenneth F. Reardon ,  David S. Dandy ,  Ryan E. Holcomb

发明人： Kenneth F. Reardon ,  David S. Dandy ,  Ryan E. Holcomb

IPC分类号： G01N21/64 ,  C12Q1/32 ,  C12Q1/00 ,  G01N21/77

摘要： Herein disclosed are biosensing systems that measure lactose concentration in a solution.

公开(公告)号：US20130244266A1

公开(公告)日：2013-09-19

申请号：US13988723

申请日：2011-11-22

申请人： Kenneth F. Reardon ,  David S. Dandy ,  Ryan E. Holcomb

发明人： Kenneth F. Reardon ,  David S. Dandy ,  Ryan E. Holcomb

IPC分类号： G01N21/64

CPC分类号： G01N21/6486 ,  C12Q1/005 ,  G01N21/6428 ,  G01N21/7703 ,  G01N2021/772 ,  G01N2021/773 ,  G01N2021/775 ,  G01N2021/7786

摘要： Herein disclosed are biosensing systems that measure lactose concentration in a solution.

摘要翻译： 本文公开了测量溶液中的乳糖浓度的生物传感系统。