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17 条记录 (耗时 0.027 秒)

    Stabilized controlled release formulations having acrylic polymer coating
    2.
    发明授权
    Stabilized controlled release formulations having acrylic polymer coating 失效
    具有丙烯酸聚合物涂层的稳定的控释制剂

    公开(公告)号：US5286493A

    公开(公告)日：1994-02-15

    申请号：US826084

    申请日：1992-01-27

    申请人： Benjamin Oshlack ,  Mark Chasin ,  Frank Pedi, Jr.

    发明人： Benjamin Oshlack ,  Mark Chasin ,  Frank Pedi, Jr.

    IPC分类号： A61J3/06 ,  A61K9/22 ,  A61K9/28 ,  A61K9/32 ,  A61K9/50 ,  A61K9/52 ,  A61K9/54 ,  A61K9/58 ,  A61K9/62 ,  A61M37/00 ,  A61K9/00

    CPC分类号： A61K9/5026 ,  A61K9/2846 ,  A61K9/5078

    摘要： A stabilized solid controlled release dosage form having a coating derived from an aqueous dispersion of an acrylic polymer is obtained by overcoating a substrate including a therapeutically active with an aqueous dispersion of the plasticized acrylic polymer and then curing the coated substrate at a temperature above the glass transition temperature of the plasticized acrylic polymer, until the coated dosage form attains a stabilized dissolution profile substantially unaffected by exposure to storage conditions of elevated temperature and/or elevated relative humidity.

    摘要翻译： 具有衍生自丙烯酸类聚合物的水性分散体的涂层的稳定的固体控制释放剂型通过用包含增塑的丙烯酸类聚合物的水性分散体的包含治疗活性的底物进行外涂，然后在高于玻璃的温度下固化涂覆的基材 直到涂覆的剂型达到稳定的溶解曲线，基本上不受暴露于升高的温度和/或相对湿度升高的储存条件的影响。

    Opioid formulations having extended controlled released
    4.
    发明授权
    Opioid formulations having extended controlled released 失效
    具有延长受控释放的阿片制剂

    公开(公告)号：US5958459A

    公开(公告)日：1999-09-28

    申请号：US561829

    申请日：1995-11-27

    申请人： Mark Chasin ,  Benjamin Oshlack ,  Frank Pedi, Jr.

    发明人： Mark Chasin ,  Benjamin Oshlack ,  Frank Pedi, Jr.

    IPC分类号： A61K9/14 ,  A61K9/16 ,  A61K9/36 ,  A61K9/62

    CPC分类号： A61K9/14 ,  A61K9/16

    摘要： Solid controlled-release oral dosage forms comprising a therapeutically effective amount of an opioid analgesic or a salt thereof which provide an extended duration of pain relief of about 24 hours, have a dissolution rate in-vitro of the dosage form, when measured by the USP Paddle Method of 100 rpm in 900 ml aqueous buffer at 37.degree. C. from about 12.5% to about 42.5% (by weight) active agent released after 1 hour, from about 25% to about 55% (by weight) active agent released after 2 hours, from about 45% to about 75% (by weight) opioid analgesic released after 4 hours and greater than about 60% (by weight) opioid analgesic released after 8 hours, the in-vitro release rate being substantially independent of pH and chosen such that the peak plasma level of active agent obtained in-vivo between about 2 and about 8 hours after administration of the dosage form.

    摘要翻译： 包含治疗有效量的阿片类止痛剂或其盐的固体控制释放口服剂型提供延长的疼痛缓解时间约24小时，当通过USP测量时具有剂型的体外溶出速率 桨式法在900ml含水缓冲液中于37℃从约12.5％至约42.5％（重量）的活性剂在1小时后释放，约25％至约55％（重量）的活性剂释放出来后释放 2小时，约4小时后释放大约45％至大约75％（重量）的阿片样物质止痛剂，并且在8小时后释放大于约60％（重量）的阿片类止痛剂，体外释放速率基本上不依赖于pH和 选择使得在施用剂型后约2至约8小时之间在体内获得的活性剂的血浆水平峰值。

    Controlled release formulations coated with aqueous dispersions of acrylic polymers
    8.
    发明授权
    Controlled release formulations coated with aqueous dispersions of acrylic polymers 失效
    用丙烯酸聚合物的水性分散体涂覆的控释剂

    公开(公告)号：US5639476A

    公开(公告)日：1997-06-17

    申请号：US459110

    申请日：1995-06-02

    申请人： Benjamin Oshlack ,  Mark Chasin ,  Frank Pedi, Jr.

    发明人： Benjamin Oshlack ,  Mark Chasin ,  Frank Pedi, Jr.

    IPC分类号： A61J3/06 ,  A61J3/00 ,  A61K9/22 ,  A61K9/24 ,  A61K9/28 ,  A61K9/32 ,  A61K9/50 ,  A61K9/52 ,  A61K9/54 ,  A61K9/56 ,  A61K9/58 ,  A61K9/62 ,  A61M37/00

    CPC分类号： A61K9/2846 ,  A61K9/5026 ,  A61K9/5078

    摘要： A stable solid controlled release formulation having a coating derived from an aqueous dispersion of a hydrophobic acrylic polymer includes a substrate including an active agent selected from the group consisting of a systemically active therapeutic agent, a locally active therapeutic agent, a disinfecting and sanitizing agent, a cleansing agent, a fragrance agent and a fertilizing agent, overcoated with an aqueous dispersion of the plasticized water-insoluble acrylic polymer. The formulation provides a stable dissolution of the active agent which is unchanged after exposure to accelerated storage conditions.

    摘要翻译： 具有衍生自疏水性丙烯酸类聚合物的水性分散体的涂层的稳定的固体控释制剂包括：底物，其包含活性剂，所述活性剂选自系统活性治疗剂，局部活性治疗剂，消毒和消毒剂， 一种清洁剂，一种香料和一种施肥剂，用增塑水不溶性丙烯酸类聚合物的水性分散体覆盖。 该制剂提供活性剂的稳定溶解，其在暴露于加速储存条件后不变。