公开(公告)号：US20140270083A1

公开(公告)日：2014-09-18

申请号：US13838565

申请日：2013-03-15

Applicant: Mark Dinsmore

Inventor： Mark Dinsmore

IPC: H01J35/02 ,  H01J9/00 ,  H05G1/10

CPC classification number: H05G1/10 ,  G21G4/08 ,  H01J35/025 ,  H01J35/16 ,  H02M3/285 ,  H02M7/003 ,  H02M7/106 ,  H02M7/25 ,  H05G1/02 ,  H05G1/06 ,  H05G1/08 ,  H05G1/12

Abstract: A device for producing x-rays includes: a housing that includes a folded high-voltage multiplier coupled to a filament transformer, the transformer coupled to an x-ray tube for producing the x-rays. A method of fabrication and an x-ray source are disclosed.

Abstract translation: 一种用于产生X射线的装置包括：壳体，其包括耦合到灯丝变压器的折叠高压乘法器，所述变压器耦合到用于产生x射线的X射线管。 公开了一种制造方法和x射线源。

公开(公告)号：US06721392B1

公开(公告)日：2004-04-13

申请号：US10005289

申请日：2001-12-04

Applicant: Mark Dinsmore

Inventor： Mark Dinsmore

IPC: A61N510

CPC classification number: A61N5/1001 ,  H01J35/32

Abstract: A minaturized tharapeutic radiation source includes a optically driven thermionic cathode having an electron-emissive surface, and a non-planar, x-ray emissive target. A fiber optic cable directs a beam of optical radiation, having a power level sufficient to heat at least a portion of the electron-emissive surface to an electron emitting temperature, from a laser source onto the cathode. An electron beam emitted from said cathode strikes the target, positioned in the electron beam path. The target includes a thin film of x-ray emissive material, adapted to emit therapeutic radiation in response to incident accelerated electrons from the electron beam, and a support structure made of x-ray transmissive material. The target has a non-planar configuration, such as a conical shape or a hemispherical shape, designed to produce a more uniform and intense radiation pattern around the target.

Abstract translation: 小型治疗辐射源包括具有电子发射表面的光学驱动的热离子阴极和非平面的X射线发射靶。 光纤电缆将具有足以将电子发射表面的至少一部分的电子发射温度从激光源加热到阴极的光辐射束引导。 从所述阴极发射的电子束撞击位于电子束路径中的靶。 靶包括x射线发射材料的薄膜，其适于响应于来自电子束的入射加速电子发射治疗辐射，以及由x射线透射材料制成的支撑结构。 目标具有非平面构造，例如圆锥形或半球形，被设计成在靶周围产生更均匀和强烈的辐射图。

公开(公告)号：US06556651B1

公开(公告)日：2003-04-29

申请号：US10133103

申请日：2002-04-26

Applicant: Euan Thomson ,  Mark Dinsmore

Inventor： Euan Thomson ,  Mark Dinsmore

IPC: A61N510

CPC classification number: A61N5/1001 ,  A61N5/1007 ,  A61N5/1014 ,  A61N2005/1012

Abstract: A system for delivering therapeutic radiation, such as x-rays, to a treatment region includes a plurality of individually controllable therapeutic radiation sources. The therapeutic radiation sources are selectively and moveably disposed along one or more axes, or upon a two-dimensional surface, or within a three-dimensional volume, so as to form a one-dimensional or a multi-dimensional array. Each therapeutic radiation source includes an electron source for emitting electrons, and an associated target element adapted to emit therapeutic radiation in response to incident electrons. In one embodiment, each therapeutic radiation source is coupled to a distal end of an associated optical delivery structure, which is adapted to direct a beam of optical radiation to impinge upon a surface of the electron source so as to cause emission of electrons therefrom.

Abstract translation: 用于将诸如x射线的治疗辐射传送到治疗区域的系统包括多个单独可控的治疗辐射源。 治疗性辐射源沿着一个或多个轴，或二维表面或三维体积内选择性地和可移动地设置，以便形成一维或多维阵列。 每个治疗辐射源包括用于发射电子的电子源和适于响应于入射电子发射治疗辐射的相关联的目标元件。 在一个实施例中，每个治疗辐射源耦合到相关联的光学传递结构的远端，其适于引导光束射束撞击电子源的表面，从而引起电子的发射。

公开(公告)号：US06195411B1

公开(公告)日：2001-02-27

申请号：US09311792

申请日：1999-05-13

Applicant: Mark Dinsmore

Inventor： Mark Dinsmore

IPC: H01J3506

CPC classification number: A61N5/1001 ,  H01J35/065 ,  H01J35/32 ,  H01J2235/087 ,  H01J2235/164

Abstract: This invention is directed to a radiation source comprising a power supply, a flexible fiber optic cable assembly, a light source, and a target assembly. The power supply includes a first terminal and a second terminal, and elements for establishing an output voltage between the first terminal and the second terminal. The flexible fiber optical cable assembly has an originating end and a terminating end, and includes a fiber optical element extending from the originating end to the terminating end. The cable is adapted for transmitting light incident on the originating end to the terminating end. The light source includes elements for generating a beam of light at and directed to the originating end of the fiber optical cable assembly. The target assembly is affixed to the terminating end of the fiber optical cable assembly and is electrically coupled to the power supply by way of the first terminal and the second terminal. The target assembly includes elements for emitting radiation in a predetermined spectral range, in response to light transmitted to the terminating end.

Abstract translation: 本发明涉及一种包括电源，柔性光缆组件，光源和目标组件的辐射源。 电源包括第一端子和第二端子，以及用于在第一端子和第二端子之间建立输出电压的元件。 柔性光纤光缆组件具有起始端和终止端，并且包括从起始端延伸到终端的光纤元件。 电缆适用于将入射在起始端的光线发射到终端。 光源包括用于在光纤光缆组件的起始端处产生光束并被引导到光纤光缆组件的始端的元件。 目标组件固定到光纤光缆组件的终端，并通过第一终端和第二终端电耦合到电源。 目标组件包括响应于传输到终端的光而在预定光谱范围内发射辐射的元件。

公开(公告)号：US20060233307A1

公开(公告)日：2006-10-19

申请号：US10481392

申请日：2002-06-18

Applicant: Mark Dinsmore

Inventor： Mark Dinsmore

IPC: H01J35/06

CPC classification number: H01J35/32 ,  H01J35/06

Abstract: A miniaturized, increased efficiency x-ray source for materials analysis includes a laser source, an optical delivery structure, a laser-driven thermionic cathode (108), an anode (122), and a target from the laser source and directs the beam onto a surface of the themionic cathode. The surfaces electrons form an electron beam along a beam path. The target element (110) is disposed in the beam path, and emits x-rays in response to incident accelerated electrons from the thermionic cathode. The target element includes an inclined surface that forms an angle of inclination (113) of about 40 degrees with respect to the electon beam path, so that x-rays are emitted from the target substantially at an angle of about 45 degrees with respect to the electron beam path.

Abstract translation: 用于材料分析的小型化，增加的效率的x射线源包括激光源，光学传递结构，激光驱动的热离子阴极（108），阳极（122）和来自激光源的靶，并将光束引导到 阴离子的表面。 表面电子沿光束路径形成电子束。 目标元件（110）设置在光束路径中，并且响应于来自热离子阴极的入射加速电子而发射X射线。 目标元件包括相对于电子束路径形成大约40度的倾斜角（113）的倾斜表面，使得x射线相对于基本上以大约45度的角度从目标射出 电子束路径。

公开(公告)号：US06856668B1

公开(公告)日：2005-02-15

申请号：US10133079

申请日：2002-04-26

Applicant: Euan Thomson ,  Mark Dinsmore

Inventor： Euan Thomson ,  Mark Dinsmore

IPC: A61N5/10

CPC classification number: A61N5/1001

Abstract: A method is provided for treating a tumor by pre-irradiation. The location, size, and shape of the tumor is identified. A region that includes the tumor as well as a surrounding portion most likely to contain residual tumorous cells is identified. The identified region is irradiated with therapeutic radiation, such as x-rays, prior to surgical removal of the tumor. The tumor is removed after irradiation of the identified region, leaving only the pre-irradiated surrounding portion. The risk of recurrence of tumorous growth after resection of the tumor may be significantly reduced.

Abstract translation: 提供了通过预照射治疗肿瘤的方法。 确定肿瘤的位置，大小和形状。 鉴定包括肿瘤的区域以及最可能含有残留肿瘤细胞的周围部分。 在手术切除肿瘤之前，用治疗辐射（例如x射线）照射所识别的区域。 在所识别的区域照射后去除肿瘤，仅留下预先照射的周围部分。 切除肿瘤后肿瘤生长复发的风险可能会显着降低。

公开(公告)号：US06480573B1

公开(公告)日：2002-11-12

申请号：US10005287

申请日：2001-12-04

Applicant: Mark Dinsmore

Inventor： Mark Dinsmore

IPC: H01J3506

CPC classification number: A61N5/1001 ,  H01J35/065 ,  H01J35/32

Abstract: A therapeutic radiation source includes a optically heated thermionic cathode that is shaped so as to maximize the coupling efficiency of the incident optical radiation to the thermionic cathode. A fiber optic cable directs a beam of radiation, having a power level sufficient to heat at east a portion of the electron-emissive surface to an electron emitting temperature, from a laser source onto the cathode. An electron beam generated by said cathode strikes a target which is positioned in its beam path and which emits therapeutic radiation in response to incident accelerated electrons from the electron beam. The thermionic cathode has a non-planar configuration, such as a conical shape and a concave shape, adapted to allow an incident ray of optical radiation to impinge upon, and undergo absorption from, a plurality of regions within the surface of the cathode in succession.

Abstract translation: 治疗辐射源包括光学加热的热离子阴极，其被成形为使入射光辐射对热离子阴极的耦合效率最大化。 光纤电缆引导辐射束，其具有足够的功率电平，使其在电子发射表面的一部分处从电子发射温度从激光源向阴极加热。 由所述阴极产生的电子束撞击定位在其光束路径中并且响应于来自电子束的入射加速电子发射治疗辐射的靶。 热离子阴极具有非平面构造，例如锥形和凹形，其适于允许光辐射的入射射线连续地撞击并吸收阴极表面内的多个区域 。

公开(公告)号：USRE41741E1

公开(公告)日：2010-09-21

申请号：US10790636

申请日：2004-03-01

Applicant: Mark Dinsmore

Inventor： Mark Dinsmore

IPC: A61N5/10

CPC classification number: H01J35/08 ,  A61N5/1001 ,  H01J35/32 ,  H01J2235/164

Abstract: A therapeutic radiation source includes a spiral-shaped, laser-heated thermionic cathode. A fiber optic cable directs a beam of radiation, having a power level sufficient to heat at least a portion of the electron-emissive surface to an electron emitting temperature, from a laser source onto the cathode. The cathode generates an electron beam along a beam path by thermionic emission, and strikes a target positioned in its beam path. The target includes radiation emissive material that emits therapeutic radiation in response to incident accelerated electrons from the electron beam. The spiral-shaped conductive element has a plurality of spaced apart turns, and is disposed in a vacuum. An interstitial spacing is defined between adjacent turns, so that heat transfer across the spacing between each adjacent turn is essentially eliminated, thereby substantially reducing heat loss in the cathode caused by thermal conduction.

Abstract translation: 治疗性辐射源包括螺旋状激光加热的热离子阴极。 光纤电缆将具有足以将至少一部分电子发射表面的电子发射温度从激光源加热到阴极的辐射束引导。 阴极通过热离子发射沿光束路径产生电子束，并且撞击位于其光束路径中的目标。 目标包括响应于来自电子束的入射加速电子发射治疗辐射的辐射发射材料。 螺旋状导电元件具有多个间隔开的匝，并且设置在真空中。 在相邻匝之间限定间隙，从而基本上消除了每个相邻匝之间的间隔的热传递，从而大大减少了由热传导引起的阴极热损失。

公开(公告)号：US20060126789A1

公开(公告)日：2006-06-15

申请号：US11009911

申请日：2004-12-10

Applicant: Mark Dinsmore ,  Thomas Engel

Inventor： Mark Dinsmore ,  Thomas Engel

IPC: H01J35/32 ,  H01J35/00 ,  H01J35/22 ,  H05G2/00 ,  G21G4/00

CPC classification number: H01J35/32 ,  A61N5/1015 ,  H01J35/065 ,  H05H6/00

Abstract: An apparatus delivers x-rays to at least a portion of an interior surface of a body cavity. The apparatus includes a flexible catheter, at least one balloon or inflatable element affixed to the catheter, one or more flexible probe assemblies, an x-ray generator assembly coupled to the distal end of each probe assembly, and a power supply means. The flexible catheter includes one or more interior channels, and each flexible probe assembly is slidably positionable within a respective interior channel of the catheter. Each balloon, when inflated, defines a predetermined surface contour disposed about an interior region of a body cavity. Each flexible probe includes a transmission path for transmitting activating energy, and may be an optical fiber for transmitting optical energy. The x-ray generator assembly includes an electron source and a target element. The electron source emits electrons in response to activating optical energy transmitted through the transmission path. The target element generates electrons in accordance with a desired radiation profile, in response to electrons impinging thereon.

Abstract translation: 一种装置将x射线传送到体腔的内表面的至少一部分。 该装置包括柔性导管，固定到导管的至少一个气囊或可充气元件，一个或多个柔性探针组件，联接到每个探针组件的远端的x射线发生器组件和电源装置。 柔性导管包括一个或多个内部通道，并且每个柔性探针组件可滑动地定位在导管的相应内部通道内。 当充气时，每个气囊限定围绕体腔的内部区域设置的预定表面轮廓。 每个柔性探针包括用于传输激活能量的传输路径，并且可以是用于传输光能的光纤。 x射线发生器组件包括电子源和靶元件。 电子源响应于通过传输路径传输的光能而发射电子。 响应于撞击其上的电子，目标元件根据期望的辐射分布产生电子。

公开(公告)号：US06658086B2

公开(公告)日：2003-12-02

申请号：US10175164

申请日：2002-06-19

Applicant: Mark Dinsmore

Inventor： Mark Dinsmore

IPC: A61N510

CPC classification number: A61N5/1001 ,  A61N2005/1022 ,  G21K1/06 ,  H01J35/06 ,  H01J35/32

Abstract: A miniaturized, optically driven, therapeutic radiation source is disclosed in which the voltage gradient between a high electron accelerating voltage and the ground potential can be controlled. The electron source and the target element are disposed within a capsule which defines a substantially evacuated region extending along an electron beam axis. The inner surface of the capsule is coated with a weakly conductive or semiconductive coating, so that a substantially uniform voltage gradient is maintained within the evacuated capsule. In this way, the chances of electric flashover or breakdown are reduced. Also, secondary emissions of electrons striking the inner wall of the capsule are reduced. X-ray production efficiency is optimized by maximizing the percentage of electrons propagated directly to the target.