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    Cyclodextrin-based polymers for therapeutics delivery
    3.
    发明授权
    Cyclodextrin-based polymers for therapeutics delivery 有权
    用于治疗输送的基于环糊精的聚合物

    公开(公告)号：US08497365B2

    公开(公告)日：2013-07-30

    申请号：US13198403

    申请日：2011-08-04

    申请人： Mark E. Davis ,  Jungyeon Hwang ,  Tianyi Ke ,  Ching-Jou Lim ,  Thomas Schluep

    发明人： Mark E. Davis ,  Jungyeon Hwang ,  Tianyi Ke ,  Ching-Jou Lim ,  Thomas Schluep

    IPC分类号： B82Y5/00

    CPC分类号： A61K47/61 ,  A61K47/65 ,  A61K47/6939 ,  A61K47/6951 ,  B82Y5/00

    摘要： The present invention relates to novel compositions comprising polymeric moieties covalently attached to therapeutic agents, wherein the therapeutic agent is attached to the polymeric moiety through a tether. By selecting from a variety of tether groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein.

    摘要翻译： 本发明涉及包含与治疗剂共价连接的聚合物部分的新型组合物，其中治疗剂通过系链连接到聚合物部分。 通过从各种系链组和靶向配体中选择，聚合物呈现用于治疗剂的受控递送的方法。 本发明还涉及用本文所述的治疗组合物治疗受试者的方法。

    CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTICS DELIVERY
    4.
    发明申请
    CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTICS DELIVERY 有权
    用于治疗药物的CYCLODEXTRIN-based聚合物

    公开(公告)号：US20110294998A1

    公开(公告)日：2011-12-01

    申请号：US13198403

    申请日：2011-08-04

    申请人： Mark E. Davis ,  Jungyeon Hwang ,  Tianyi Ke ,  Ching-Jou Lim ,  Thomas Schluep

    发明人： Mark E. Davis ,  Jungyeon Hwang ,  Tianyi Ke ,  Ching-Jou Lim ,  Thomas Schluep

    IPC分类号： C08B37/16

    CPC分类号： A61K47/61 ,  A61K47/65 ,  A61K47/6939 ,  A61K47/6951 ,  B82Y5/00

    摘要： The present invention relates to novel compositions comprising polymeric moieties covalently attached to therapeutic agents, wherein the therapeutic agent is attached to the polymeric moiety through a tether. By selecting from a variety of tether groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein.

    摘要翻译： 本发明涉及包含与治疗剂共价连接的聚合物部分的新型组合物，其中治疗剂通过系链连接到聚合物部分。 通过从各种系链组和靶向配体中选择，聚合物呈现用于治疗剂的受控递送的方法。 本发明还涉及用本文所述的治疗组合物治疗受试者的方法。

    MRI-Guided Photodynamic Therapy For Cancer
    6.
    发明申请
    MRI-Guided Photodynamic Therapy For Cancer 审中-公开
    MRI引导光动力治疗癌症

    公开(公告)号：US20090076571A1

    公开(公告)日：2009-03-19

    申请号：US11792206

    申请日：2005-12-02

    申请人： Zheng-Rong Lu ,  Anagha Vaidya ,  Tianyi Ke

    发明人： Zheng-Rong Lu ,  Anagha Vaidya ,  Tianyi Ke

    IPC分类号： A61N5/06 ,  A61K49/00 ,  A61K49/06 ,  A61B5/055 ,  C07K2/00 ,  A61K49/14

    CPC分类号： A61K49/085 ,  A61K41/0071 ,  A61K47/645 ,  A61K49/146

    摘要： Disclosed is a method of therapy used in combination with a diagnostic tool for enhanced photodynamic therapy using MRI, called (magnetic resonance imaging)-guided photodynamic therapy. The methods of the present invention includes administration of MRI contrast agent labeled polymer photosensitizer conjugates, detection and localization of tumor or cancer tissues with contrast-enhanced MRI and specific illumination and treatment of localized target tissues, such as tumors or cancer cells, using laser energy. The delivered laser energy activates the photosensitizer accumulated in the target tissue, resulting in treatment. Also disclosed are novel conjugate compounds, such as PLGA-Mce6-DOTA-Gd complexes, having multi-functionality in that the complex may include an MRI contrasting agent linked to a photosensitizing agent.

    摘要翻译： 公开了一种治疗方法，与用于使用称为（磁共振成像） - 光导光疗法的MRI的增强光动力疗法的诊断工具结合使用。 本发明的方法包括施用MRI造影剂标记的聚合物光敏剂缀合物，使用对比度增强的MRI和特定照明的肿瘤或癌组织的检测和定位以及使用激光能量的局部靶组织如肿瘤或癌细胞的治疗 。 递送的激光能量激活积聚在靶组织中的光敏剂，从而进行治疗。 还公开了具有多功能性的新型缀合物化合物，例如PLGA-Mce6-DOTA-Gd复合物，因为该复合物可包括与光敏剂连接的MRI造影剂。