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    Cyclodextrin-based polymers for therapeutics delivery
    3.
    发明授权
    Cyclodextrin-based polymers for therapeutics delivery 有权
    用于治疗输送的基于环糊精的聚合物

    公开(公告)号：US08497365B2

    公开(公告)日：2013-07-30

    申请号：US13198403

    申请日：2011-08-04

    申请人： Mark E. Davis ,  Jungyeon Hwang ,  Tianyi Ke ,  Ching-Jou Lim ,  Thomas Schluep

    发明人： Mark E. Davis ,  Jungyeon Hwang ,  Tianyi Ke ,  Ching-Jou Lim ,  Thomas Schluep

    IPC分类号： B82Y5/00

    CPC分类号： A61K47/61 ,  A61K47/65 ,  A61K47/6939 ,  A61K47/6951 ,  B82Y5/00

    摘要： The present invention relates to novel compositions comprising polymeric moieties covalently attached to therapeutic agents, wherein the therapeutic agent is attached to the polymeric moiety through a tether. By selecting from a variety of tether groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein.

    摘要翻译： 本发明涉及包含与治疗剂共价连接的聚合物部分的新型组合物，其中治疗剂通过系链连接到聚合物部分。 通过从各种系链组和靶向配体中选择，聚合物呈现用于治疗剂的受控递送的方法。 本发明还涉及用本文所述的治疗组合物治疗受试者的方法。

    CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTICS DELIVERY
    4.
    发明申请
    CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTICS DELIVERY 有权
    用于治疗药物的CYCLODEXTRIN-based聚合物

    公开(公告)号：US20110294998A1

    公开(公告)日：2011-12-01

    申请号：US13198403

    申请日：2011-08-04

    申请人： Mark E. Davis ,  Jungyeon Hwang ,  Tianyi Ke ,  Ching-Jou Lim ,  Thomas Schluep

    发明人： Mark E. Davis ,  Jungyeon Hwang ,  Tianyi Ke ,  Ching-Jou Lim ,  Thomas Schluep

    IPC分类号： C08B37/16

    CPC分类号： A61K47/61 ,  A61K47/65 ,  A61K47/6939 ,  A61K47/6951 ,  B82Y5/00

    摘要： The present invention relates to novel compositions comprising polymeric moieties covalently attached to therapeutic agents, wherein the therapeutic agent is attached to the polymeric moiety through a tether. By selecting from a variety of tether groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein.

    摘要翻译： 本发明涉及包含与治疗剂共价连接的聚合物部分的新型组合物，其中治疗剂通过系链连接到聚合物部分。 通过从各种系链组和靶向配体中选择，聚合物呈现用于治疗剂的受控递送的方法。 本发明还涉及用本文所述的治疗组合物治疗受试者的方法。

    Polymer encapsulation of adenoviruses
    6.
    发明申请
    Polymer encapsulation of adenoviruses 审中-公开
    腺病毒的聚合物包封

    公开(公告)号：US20050031579A1

    公开(公告)日：2005-02-10

    申请号：US10870813

    申请日：2004-06-16

    申请人： Thomas Schluep

    发明人： Thomas Schluep

    IPC分类号： A61K39/23 ,  A61K39/235 ,  A61K47/48 ,  A61K48/00 ,  C08K20060101 ,  C12N15/861

    CPC分类号： C12N15/86 ,  A61K47/59 ,  A61K47/60 ,  A61K47/6901 ,  A61K48/0041 ,  C08B37/0021 ,  C08L5/02 ,  C08L79/02 ,  C12N7/00 ,  C12N2710/10051 ,  C12N2800/95

    摘要： The present invention provides a copolymer that noncovalently encapsulates an adenovirus while improving its delivery and resulting expression from the viral genome. It has now been discovered that a copolymer of a cationic polymer, such as PEI, polylysine, DEAE-Dextran, and derivatives thereof, and a nonionic polymer, such as PEG and derivatives thereof, can improve both delivery and transgene expression of the adenovirus in cells. The complex of the invention provides an easy-to-produce material that is therapeutically more effective than an unencapsulated adenovirus.

    摘要翻译： 本发明提供了一种非极性包封腺病毒同时改善其递送和从病毒基因组得到的表达的共聚物。 现在已经发现，阳离子聚合物如PEI，聚赖氨酸，DEAE-葡聚糖及其衍生物和非离子聚合物如PEG及其衍生物的共聚物可以改善腺病毒的递送和转基因表达 细胞。 本发明的复合物提供易于生产的材料，其在治疗上比未包封的腺病毒更有效。

    IRREVERSIBLE LOCKING MECHANISM
    9.
    发明申请
    IRREVERSIBLE LOCKING MECHANISM 审中-公开
    不可克服的锁定机制

    公开(公告)号：US20100011547A1

    公开(公告)日：2010-01-21

    申请号：US12174029

    申请日：2008-07-16

    申请人： Thomas Schluep ,  Carl Pancutt

    发明人： Thomas Schluep ,  Carl Pancutt

    IPC分类号： A44B13/00

    CPC分类号： F16B45/04 ,  F16B39/32 ,  Y10T24/45361

    摘要： Embodiments of an irreversible locking mechanism are presented herein. According to one embodiment, an irreversible locking mechanism comprises a body, a gate, and a spring-loaded pin. The body comprises two opposing ends separated by a gap. The gate is supported by a first of the two opposing ends and advances from the first opposing end to span the gap and engage a second of the two opposing ends such that the gate is engaged with the first and second opposing ends of the body. The gate transitions from an advancing state, where the spring-loaded pin is depressed within a seat in the first opposing end by the gate and the gate is free to span the gap, to an irreversible locked state, where the gate engages the second opposing end and the spring-loaded pin projects from the seat in the first opposing end into a catch of the gate.

    摘要翻译： 本文给出了不可逆锁定机构的实施例。 根据一个实施例，不可逆锁定机构包括主体，门和弹簧加载销。 主体包括由间隙分开的两个相对端。 门由两个相对端中的第一个支撑并且从第一相对端前进到跨过间隙并且接合两个相对端中的第二个，使得门与主体的第一和第二相对端接合。 门从前进状态转变，其中弹簧加载的销在门的第一相对端的座中被压入，并且门可自由跨越间隙到不可逆的锁定状态，其中门接合第二相对 并且弹簧加载的销从第一相对端中的座突出到闸门的卡扣。

    Automatic door opening and closing system and method of control thereof
    10.
    发明申请
    Automatic door opening and closing system and method of control thereof 有权
    自动开门关闭系统及其控制方法

    公开(公告)号：US20070008124A1

    公开(公告)日：2007-01-11

    申请号：US11365287

    申请日：2006-03-01

    申请人： Michael Stadler ,  Thomas Schluep ,  Joseph DeSisto

    发明人： Michael Stadler ,  Thomas Schluep ,  Joseph DeSisto

    IPC分类号： G08B13/08

    CPC分类号： E05F15/43 ,  E05F15/611 ,  E05F15/73 ,  E05F2015/437 ,  E05F2015/483 ,  E05Y2600/45 ,  E05Y2600/46 ,  E05Y2900/132

    摘要： A swinging automatic door control system includes an activation sensor for acquiring images of a first area where the door swings when opening or closing, a presence sensor for detecting motion in a second area that fronts a non-swinging side of the door when said door is closed, and a controller for controlling the opening and closing of the door as a function of the acquired images of a first area and the detection of motion in the second area.

    摘要翻译： 一种摆动式自动门控制系统，包括一个启动传感器，用于获取打开或关闭门时门摆动的第一区域的图像;存在传感器，用于在所述门是门时在门的非摆动侧面前方的第二区域中检测运动; 关闭，以及用于根据获取的第一区域的图像和第二区域中的运动检测来控制门的打开和关闭的控制器。