公开(公告)号：US20090253634A1

公开(公告)日：2009-10-08

申请号：US12064116

申请日：2006-08-21

申请人： Mark G. Currie ,  Shalina Mahajan-Miklos ,  Angelika Fretzen ,  Li Jing Sun ,  Caroline Kurtz ,  G. Todd Milne ,  Thea Norman ,  Shannon Roberts ,  E. Kelly Sullivan

发明人： Mark G. Currie ,  Shalina Mahajan-Miklos ,  Angelika Fretzen ,  Li Jing Sun ,  Caroline Kurtz ,  G. Todd Milne ,  Thea Norman ,  Shannon Roberts ,  E. Kelly Sullivan

IPC分类号： A61K38/10 ,  C07K7/00

CPC分类号： C07K7/08 ,  C07K14/4705

摘要： The present invention features compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastnoesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, Inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo-obstruction), and disorders and conditions associated with constipation, e.g. constipation associated with use of opiate pain killers, post-surgical constipation (post-operative ileus), and constipation associated with neuropathic disorders as well as other conditions and disorders using peptides and other agents that activate the guanylate cyclase C (GC-C) receptor.

摘要翻译： 本发明的特征在于用于治疗IBS和其他胃肠道疾病和病症（例如胃肠蠕动障碍，功能性胃肠道疾病，胃食管反流病（GERD），十二指肠胃反流，克罗恩病，溃疡性结肠炎，炎性肠病，功能性胃灼热的组合物和相关方法 ，消化不良（包括功能性消化不良或非溃疡性消化不良），胃轻瘫，慢性肠假性梗阻（或结肠假性梗阻）以及与便秘相关的疾病和病症，例如与使用阿片类止痛药相关的便秘，手术后便秘（post 手术肠梗阻）和与神经性疾病相关的便秘以及使用活化鸟苷酸环化酶C（GC-C）受体的肽和其他试剂的其它病症和病症。