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公开(公告)号：US07960544B2
公开(公告)日：2011-06-14
申请号：US12097616
申请日：2006-12-18
申请人： Wilmin Bartolini , Brian M. Cali , Barbara Chen , Yueh-Tyng Chien , Mark G. Currie , G. Todd Milne , James Philip Pearson , John Jeffrey Talley , Jane Yang , Craig Zimmerman , Charles Kim , Kevin Sprott , Timothy Barden , Regina Lundigran , Ara Mermerian
发明人： Wilmin Bartolini , Brian M. Cali , Barbara Chen , Yueh-Tyng Chien , Mark G. Currie , G. Todd Milne , James Philip Pearson , John Jeffrey Talley , Jane Yang , Craig Zimmerman , Charles Kim , Kevin Sprott , Timothy Barden , Regina Lundigran , Ara Mermerian
IPC分类号： C07D403/06 , C07D239/26 , C07D471/04 , C07D401/06 , C07D271/06 , C07D271/10 , C07D417/06 , C07D413/06 , C07D263/32 , C07D261/08
CPC分类号： C07D209/42 , C07D209/30 , C07D401/06 , C07D409/06 , C07D417/06
摘要： Indoles that have activity as inhibitors of FAAH are described as are indoles and indole derivatives that have activity as inhibitors of DAO.
摘要翻译： 具有作为FAAH抑制剂的活性的吲哚被描述为具有作为DAO抑制剂的活性的吲哚和吲哚衍生物。
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2.发明申请公开(公告)号：US20090062207A1
公开(公告)日：2009-03-05
申请号：US11054071
申请日：2005-02-08
申请人： Mark G. Currie , Shalina Mahajan-Miklos , Angelika Fretzen , Li Jing Sun , Caroline Kurtz , Thea Norman , G. Todd Milne
发明人： Mark G. Currie , Shalina Mahajan-Miklos , Angelika Fretzen , Li Jing Sun , Caroline Kurtz , Thea Norman , G. Todd Milne
CPC分类号： C07K5/1016 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/195 , C07K14/245 , C07K14/705
摘要： The present invention features compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, Inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo-obstruction), and disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation (post-operative ileus), and constipation associated with neuropathic disorders as well as other conditions and disorders using peptides and other agents that activate the guanylate cyclase C (GC-C) receptor.
摘要翻译： 本发明的特征在于用于治疗IBS和其他胃肠道疾病和病症（例如胃肠蠕动障碍，功能性胃肠道疾病，胃食管反流病（GERD），十二指肠胃反流，克罗恩病，溃疡性结肠炎，炎性肠病，功能性胃灼热的组合物和相关方法 ，消化不良（包括功能性消化不良或非溃疡性消化不良），胃轻瘫，慢性肠假性梗阻（或结肠假性梗阻）以及与便秘相关的疾病和病症，例如与使用阿片类止痛药相关的便秘，手术后便秘（ 术后肠梗阻）和与神经性疾病相关的便秘以及使用活化鸟苷酸环化酶C（GC-C）受体的肽和其它试剂的其它病症和障碍。
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3.发明授权公开(公告)号：US07371727B2
公开(公告)日：2008-05-13
申请号：US10899806
申请日：2004-07-27
申请人： Mark G. Currie , Shalina Mahajan-Miklos , Angelika Fretzen , Li Jing Sun , Thea Norman , G. Todd Milne
发明人： Mark G. Currie , Shalina Mahajan-Miklos , Angelika Fretzen , Li Jing Sun , Thea Norman , G. Todd Milne
IPC分类号： A61K38/10
CPC分类号： C07K5/1016 , A61K36/17 , A61K36/38 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/00 , A61K2300/00
摘要： The present invention features compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, Inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo-obstruction), and disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation (post-operative ileus), and constipation associated with neuropathic disorders as well as other conditions and disorders using peptides and other agents that activate the guanylate cyclase C (GC-C) receptor.
摘要翻译： 本发明的特征在于用于治疗IBS和其他胃肠道疾病和病症（例如胃肠蠕动障碍，功能性胃肠道疾病，胃食管反流病（GERD），十二指肠胃反流，克罗恩病，溃疡性结肠炎，炎性肠病，功能性胃灼热的组合物和相关方法 ，消化不良（包括功能性消化不良或非溃疡性消化不良），胃轻瘫，慢性肠假性梗阻（或结肠假性梗阻）以及与便秘相关的疾病和病症，例如与使用阿片类止痛药相关的便秘，手术后便秘（ 术后肠梗阻）和与神经性疾病相关的便秘以及使用活化鸟苷酸环化酶C（GC-C）受体的肽和其它试剂的其它病症和障碍。
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4.发明申请Methods and Compositions for the Treatment of Heart Failure and Other Disorders 有权用于治疗心力衰竭和其他疾病的方法和组合公开(公告)号：US20120040892A9
公开(公告)日：2012-02-16
申请号：US12528737
申请日：2008-02-26
申请人： Daniel Zimmer , Angelika Fretzen , Mark Currie , G. Todd Milne
发明人： Daniel Zimmer , Angelika Fretzen , Mark Currie , G. Todd Milne
IPC分类号： A61K38/10 , A61P9/04 , A61P9/00 , A61P9/12 , A61P35/00 , A61P29/00 , A61P1/08 , A61P1/12 , A61P1/16 , A61P1/04 , A61P1/00 , C07K7/08 , A61P3/04
摘要： Peptides that act as GC-C receptor agonists and contain at least one D-cys and are useful for the treatment of diuresis and heart disease as well as other disorders are described.
摘要翻译： 描述了充当GC-C受体激动剂并且含有至少一种D-cys并且可用于治疗利尿和心脏病以及其它病症的肽。
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5.发明授权公开(公告)号：US08080526B2
公开(公告)日：2011-12-20
申请号：US12754138
申请日：2010-04-05
IPC分类号： A61K38/10
CPC分类号： C07K7/08 , A61K38/00 , C07K14/245
摘要： The present invention features compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), Crohn's disease, ulcerative colitis, Inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo-obstruction), and disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation, and constipation associated with neuropathic disorders as well as other conditions and disorders using peptides and other agents that activate the guanylate cyclase C (GC-C) receptor.
摘要翻译： 本发明的特征在于用于治疗IBS和其他胃肠道疾病和病症（例如胃肠蠕动障碍，功能性胃肠道疾病，胃食管反流病（GERD），克罗恩病，溃疡性结肠炎，炎性肠病，功能性胃灼热，消化不良（ 包括功能性消化不良或非溃疡性消化不良），胃轻瘫，慢性肠假性梗阻（或结肠假性梗阻）以及与便秘相关的疾病和病症，例如与使用阿片类止痛药相关的便秘，手术后便秘和便秘相关 与使用活化鸟苷酸环化酶C（GC-C）受体的肽和其他试剂的神经性疾病以及其它病症和病症。
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6.发明授权公开(公告)号：US07704947B2
公开(公告)日：2010-04-27
申请号：US11930696
申请日：2007-10-31
IPC分类号： C07K7/08
CPC分类号： C07K7/08 , A61K38/00 , C07K14/245
摘要： The present invention features compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), Crohn's disease, ulcerative colitis, Inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo-obstruction), and disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation, and constipation associated with neuropathic disorders as well as other conditions and disorders using peptides and other agents that activate the guanylate cyclase C (GC-C) receptor.
摘要翻译： 本发明的特征在于用于治疗IBS和其他胃肠道疾病和病症（例如胃肠蠕动障碍，功能性胃肠道疾病，胃食管反流病（GERD），克罗恩病，溃疡性结肠炎，炎性肠病，功能性胃灼热，消化不良（ 包括功能性消化不良或非溃疡性消化不良），胃轻瘫，慢性肠假性梗阻（或结肠假性梗阻）以及与便秘相关的疾病和病症，例如与使用阿片类止痛药相关的便秘，手术后便秘和便秘相关 与使用活化鸟苷酸环化酶C（GC-C）受体的肽和其他试剂的神经性疾病以及其它病症和病症。
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公开(公告)号：US20090005534A1
公开(公告)日：2009-01-01
申请号：US11930696
申请日：2007-10-31
IPC分类号： C07K7/08
CPC分类号： C07K7/08 , A61K38/00 , C07K14/245
摘要： The present invention features compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), Crohn's disease, ulcerative colitis, Inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo-obstruction), and disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation, and constipation associated with neuropathic disorders as well as other conditions and disorders using peptides and other agents that activate the guanylate cyclase C (GC-C) receptor.
摘要翻译： 本发明的特征在于用于治疗IBS和其他胃肠道疾病和病症（例如胃肠蠕动障碍，功能性胃肠道疾病，胃食管反流病（GERD），克罗恩病，溃疡性结肠炎，炎性肠病，功能性胃灼热，消化不良（ 包括功能性消化不良或非溃疡性消化不良），胃轻瘫，慢性肠假性梗阻（或结肠假性梗阻）以及与便秘相关的疾病和病症，例如与使用阿片类止痛药相关的便秘，手术后便秘和便秘相关 与使用活化鸟苷酸环化酶C（GC-C）受体的肽和其他试剂的神经性疾病以及其它病症和病症。
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8.发明授权公开(公告)号：US08110553B2
公开(公告)日：2012-02-07
申请号：US12788979
申请日：2010-05-27
IPC分类号： A61K38/10
CPC分类号： C07K7/08 , C07K14/245
摘要： The present invention features compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), Crohn's disease, ulcerative colitis, Inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo-obstruction), and disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation (post-operative ileus), and constipation associated with neuropathic disorders as well as other conditions and disorders using peptides and other agents that activate the guanylate cyclase C (GC-C) receptor.
摘要翻译： 本发明的特征在于用于治疗IBS和其他胃肠道疾病和病症（例如胃肠蠕动障碍，功能性胃肠道疾病，胃食管反流病（GERD），克罗恩病，溃疡性结肠炎，炎性肠病，功能性胃灼热，消化不良（ 包括功能性消化不良或非溃疡性消化不良），胃轻瘫，慢性肠假性梗阻（或结肠假性梗阻）以及与便秘相关的疾病和病症，例如与使用阿片类止痛药相关的便秘，手术后便秘 肠梗阻）和与神经性疾病相关的便秘以及使用活化鸟苷酸环化酶C（GC-C）受体的肽和其它试剂的其他病症和病症。
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9.发明授权公开(公告)号：US07910546B2
公开(公告)日：2011-03-22
申请号：US12120023
申请日：2008-05-13
申请人： Mark G. Currie , Shalina Mahajan-Miklos , Angelika Fretzen , Li Jing Sun , Thea Norman , G. Todd Milne
发明人： Mark G. Currie , Shalina Mahajan-Miklos , Angelika Fretzen , Li Jing Sun , Thea Norman , G. Todd Milne
IPC分类号： C12N1/21
CPC分类号： C07K5/1016 , A61K36/17 , A61K36/38 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/00 , A61K2300/00
摘要： The present invention features compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, Inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo-obstruction), and disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation (post-operative ileus), and constipation associated with neuropathic disorders as well as other conditions and disorders using peptides and other agents that activate the guanylate cyclase C (GC-C) receptor.
摘要翻译： 本发明的特征在于用于治疗IBS和其他胃肠道疾病和病症（例如胃肠蠕动障碍，功能性胃肠道疾病，胃食管反流病（GERD），十二指肠胃反流，克罗恩病，溃疡性结肠炎，炎性肠病，功能性胃灼热的组合物和相关方法 ，消化不良（包括功能性消化不良或非溃疡性消化不良），胃轻瘫，慢性肠假性梗阻（或结肠假性梗阻）以及与便秘相关的疾病和病症，例如与使用阿片类止痛药相关的便秘，手术后便秘（ 术后肠梗阻）和与神经性疾病相关的便秘以及使用活化鸟苷酸环化酶C（GC-C）受体的肽和其它试剂的其它病症和障碍。
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10.发明申请公开(公告)号：US20090253634A1
公开(公告)日：2009-10-08
申请号：US12064116
申请日：2006-08-21
申请人： Mark G. Currie , Shalina Mahajan-Miklos , Angelika Fretzen , Li Jing Sun , Caroline Kurtz , G. Todd Milne , Thea Norman , Shannon Roberts , E. Kelly Sullivan
发明人： Mark G. Currie , Shalina Mahajan-Miklos , Angelika Fretzen , Li Jing Sun , Caroline Kurtz , G. Todd Milne , Thea Norman , Shannon Roberts , E. Kelly Sullivan
CPC分类号： C07K7/08 , C07K14/4705
摘要： The present invention features compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastnoesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, Inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo-obstruction), and disorders and conditions associated with constipation, e.g. constipation associated with use of opiate pain killers, post-surgical constipation (post-operative ileus), and constipation associated with neuropathic disorders as well as other conditions and disorders using peptides and other agents that activate the guanylate cyclase C (GC-C) receptor.
摘要翻译： 本发明的特征在于用于治疗IBS和其他胃肠道疾病和病症（例如胃肠蠕动障碍，功能性胃肠道疾病，胃食管反流病（GERD），十二指肠胃反流，克罗恩病，溃疡性结肠炎，炎性肠病，功能性胃灼热的组合物和相关方法 ，消化不良（包括功能性消化不良或非溃疡性消化不良），胃轻瘫，慢性肠假性梗阻（或结肠假性梗阻）以及与便秘相关的疾病和病症，例如与使用阿片类止痛药相关的便秘，手术后便秘（post 手术肠梗阻）和与神经性疾病相关的便秘以及使用活化鸟苷酸环化酶C（GC-C）受体的肽和其他试剂的其它病症和病症。
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