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公开(公告)号:US20090275659A1
公开(公告)日:2009-11-05
申请号:US12317066
申请日:2008-12-18
申请人: Mark Grillo , An-Rong Li , Jiwen Liu , Julio C. Medina , Yongli Su , Yingcai Wang , Janan Jona , Alan Allgeier , Jacqueline Milne , Jerry Murry , Joseph F. Payack , Thomas Storz
发明人: Mark Grillo , An-Rong Li , Jiwen Liu , Julio C. Medina , Yongli Su , Yingcai Wang , Janan Jona , Alan Allgeier , Jacqueline Milne , Jerry Murry , Joseph F. Payack , Thomas Storz
IPC分类号: A61K31/196 , C07C311/21 , A61P11/06 , C07C255/50
CPC分类号: C07C311/29 , C07C311/21 , C07C2601/02 , C07C2601/04
摘要: Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of inflammatory and immune-related diseases and conditions. In particular, the invention provides compounds which modulate the function and/or expression of proteins involved in atopic diseases, inflammatory conditions and cancer. The subject compounds are carboxylic acid derivatives.
摘要翻译: 提供了可用于治疗炎症和免疫相关疾病和病症的化合物,药物组合物和方法。 特别地,本发明提供调节参与特应性疾病,炎性病症和癌症的蛋白质的功能和/或表达的化合物。 主题化合物是羧酸衍生物。
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公开(公告)号:US08183293B2
公开(公告)日:2012-05-22
申请号:US12317066
申请日:2008-12-18
申请人: Mark Grillo , An-Rong Li , Jiwen Liu , Julio C. Medina , Yongli Su , Yingcai Wang , Janan Jona , Alan Allgeier , Jacqueline Milne , Jerry Murry , Joseph F. Payack , Thomas Storz
发明人: Mark Grillo , An-Rong Li , Jiwen Liu , Julio C. Medina , Yongli Su , Yingcai Wang , Janan Jona , Alan Allgeier , Jacqueline Milne , Jerry Murry , Joseph F. Payack , Thomas Storz
IPC分类号: A61K31/18 , C07C311/08
CPC分类号: C07C311/29 , C07C311/21 , C07C2601/02 , C07C2601/04
摘要: Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of inflammatory and immune-related diseases and conditions. In particular, the invention provides compounds which modulate the function and/or expression of proteins involved in atopic diseases, inflammatory conditions and cancer. The subject compounds are carboxylic acid derivatives.
摘要翻译: 提供了可用于治疗炎症和免疫相关疾病和病症的化合物,药物组合物和方法。 特别地,本发明提供调节参与特应性疾病,炎性病症和癌症的蛋白质的功能和/或表达的化合物。 主题化合物是羧酸衍生物。
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