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公开(公告)号：US07208300B2
公开(公告)日：2007-04-24
申请号：US09924946
申请日：2001-08-08
申请人： Mark J. Evans , Marshall S. Scicchitano , Ashok R. Bapat , Ramesh A. Bhat , Robert Mastroeni , Sotirios K. Karathanasis
发明人： Mark J. Evans , Marshall S. Scicchitano , Ashok R. Bapat , Ramesh A. Bhat , Robert Mastroeni , Sotirios K. Karathanasis
CPC分类号： C12N9/0022
摘要： The present invention relates to a novel lysyl oxidase genes, termed EER-7. The invention relates to the protein and nucleic acids encoding the protein. The invention further relates to an assay system to identify compounds that selectively modulate EER-7 protein activity by interaction with estrogen receptors.
摘要翻译： 本发明涉及一种称为EER-7的新型赖氨酰氧化酶基因。 本发明涉及编码蛋白质的蛋白质和核酸。 本发明还涉及鉴定通过与雌激素受体相互作用选择性调节EER-7蛋白活性的化合物的测定系统。
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公开(公告)号：US07445920B2
公开(公告)日：2008-11-04
申请号：US10456982
申请日：2003-06-06
申请人： Mark J. Evans , Marshall S. Scicchitano , Ashok R. Bapat , Ramesh A. Bhat , Robert Mastroeni , Sotirios K. Karathanasis
发明人： Mark J. Evans , Marshall S. Scicchitano , Ashok R. Bapat , Ramesh A. Bhat , Robert Mastroeni , Sotirios K. Karathanasis
CPC分类号： C12N9/0022
摘要： The present invention relates to a novel lysyl oxidase genes, termed EER-7. The invention relates to the protein and nucleic acids encoding the protein. The invention further relates to an assay system to identify compounds that selectively modulate EER-7 protein activity by interaction with estrogen receptors.
摘要翻译： 本发明涉及一种称为EER-7的新型赖氨酰氧化酶基因。 本发明涉及编码蛋白质的蛋白质和核酸。 本发明还涉及鉴定通过与雌激素受体相互作用选择性调节EER-7蛋白活性的化合物的测定系统。
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3.发明授权Assay to identify estrogen receptor dependent ligands that regulate the hepatic lipase promoter 失效测定确定调节肝脂肪酶启动子的雌激素受体依赖性配体公开(公告)号：US07521199B2
公开(公告)日：2009-04-21
申请号：US11471781
申请日：2006-06-21
CPC分类号： C12Q1/6897 , G01N33/743
摘要： The present invention relates to an assay system and method for testing compounds for their ability to regulate the hepatic lipase (HL) promoter. In particular, the invention relates to the identification of estrogen receptor ligands having this activity. Compounds that inhibit HL promoter activity are useful as leads, or on their own, to develop therapeutics in the prevention of heart disease.
摘要翻译： 本发明涉及测定化合物调节肝脂肪酶（HL）启动子的能力的测定系统和方法。 特别地，本发明涉及鉴定具有该活性的雌激素受体配体。 抑制HL启动子活性的化合物可用作引导，或自己用于开发预防心脏病的治疗剂。
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4.发明授权公开(公告)号：US07094559B1
公开(公告)日：2006-08-22
申请号：US09924944
申请日：2001-08-08
CPC分类号： C12Q1/6897 , G01N33/743
摘要： The present invention relates to an assay system and method for testing compounds for their ability to regulate the hepatic lipase (HL) promoter. In particular, the invention relates to the identification of estrogen receptor ligands having this activity. Compounds that inhibit HL promoter activity are useful as leads, or on their own, to develop therapeutics in the prevention of heart disease.
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