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    Methods of preparing substituted tetracyclines with transition metal-based chemistries
    1.
    发明申请
    Methods of preparing substituted tetracyclines with transition metal-based chemistries 有权
    用过渡金属化学制备取代四环素的方法

    公开(公告)号：US20050187198A1

    公开(公告)日：2005-08-25

    申请号：US11004559

    申请日：2004-12-03

    申请人： Mark Nelson ,  Glen Rennie ,  Darrell Koza

    发明人： Mark Nelson ,  Glen Rennie ,  Darrell Koza

    IPC分类号： C07C231/12 ,  C07C237/26 ,  C07D295/185 ,  C07D295/192 ,  A61K31/65

    CPC分类号： C07D295/185 ,  C07C231/12 ,  C07C237/26 ,  C07C2603/46 ,  C07D295/192

    摘要： The present invention relates to novel chemistries which allow for heretofore unobtainable substituted tetracycline compounds which exhibit significant activity in tetracycline responsive states. The methods disclosed herein utilize reactive tetracycline-based precursor compounds, reactive organic substituent precursors and transition metal catalysts under conditions such that a tetracycline compound substituted with the desired organic substituent is formed. In one embodiment of the invention, a substituted tetracycline compound may be prepared by combining a reactive tetracycline-based precursor compound such as an arene tetracycline diazonium salt, and a reactive organic substituent precursor, e.g., alkenes, substituted alkenes, vinyl monomers, aromatics and heteroaromatics, in the presence of a transition metal catalyst, such as palladium chloride, under conditions such that a tetracycline compound substituted with the organic substituent is formed. Such compounds may optionally act as intermediates for making other compounds, e.g., hydrogenation of unsaturated groups on the substituent.

    摘要翻译： 本发明涉及允许迄今为止在四环素反应状态下表现出显着活性的未获得的取代四环素化合物的新化学物质。 本文公开的方法在形成被所需有机取代基取代的四环素化合物的条件下使用基于活性四环素的前体化合物，反应性有机取代基前体和过渡金属催化剂。 在本发明的一个实施方案中，取代的四环素化合物可以通过将活性四环素类前体化合物如芳族四环素重氮盐和反应性有机取代基前体例如烯烃，取代的烯烃，乙烯基单体，芳族化合物和 在过渡金属催化剂如氯化钯存在下，在形成被有机取代基取代的四环素化合物的条件下，进行杂芳族化合物。 这样的化合物可以任选地用作制备其它化合物的中间体，例如取代基上不饱和基团的氢化。

    7, 8 And 9-substituted tetracycline compounds
    6.
    发明申请
    7, 8 And 9-substituted tetracycline compounds 有权
    7,8和9-取代四环素化合物

    公开(公告)号：US20060229282A1

    公开(公告)日：2006-10-12

    申请号：US11454221

    申请日：2006-06-16

    申请人： Mark Nelson ,  Darrell Koza ,  Glen Rennie

    发明人： Mark Nelson ,  Darrell Koza ,  Glen Rennie

    IPC分类号： A61K31/65

    CPC分类号： C07C237/26

    摘要： 7, 8 and 9-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7, 8 and 9-substituted tetracycline compounds are described.

    摘要翻译： 7,8和9-取代的四环素化合物，治疗四环素应答状态的方法，以及含有7,8和9-取代的四环素化合物的药物组合物。

    Methods of preparing substituted tetracyclines with transition metal-based chemistries
    7.
    发明申请
    Methods of preparing substituted tetracyclines with transition metal-based chemistries 失效

    公开(公告)号：US20060166946A1

    公开(公告)日：2006-07-27

    申请号：US11390902

    申请日：2006-03-28

    申请人： Mark Nelson ,  Glen Rennie ,  Darrell Koza

    发明人： Mark Nelson ,  Glen Rennie ,  Darrell Koza

    IPC分类号： A61K31/65 ,  C07C237/26

    CPC分类号： C07C237/26 ,  C07C231/12 ,  C07C2603/46

    摘要： The present invention relates to novel chemistries which allow for heretofore unobtainable substituted tetracycline compounds which exhibit significant antibacterial activity. The methods disclosed herein utilize reactive tetracycline-based precursor compounds, reactive organic substituent precursors and transition metal catalysts under conditions such that a tetracycline compound substituted with the desired organic substituent is formed. In one embodiment of the invention, a substituted tetracycline compound may be prepared by combining a reactive tetracycline-based precursor compound such as an arene tetracycline diazonium salt, and a reactive organic substituent precursor, e.g., alkenes, substituted alkenes, vinyl monomers, aromatics and heteroaromatics, in the presence of a transition metal catalyst, such as palladium chloride, under conditions such that a tetracycline compound substituted with the organic substituent is formed. Such compounds may optionally act as intermediates for making other compounds, e.g., hydrogenation of unsaturated groups on the substituent.

    Introducer Handle Notch Design/Concept
    9.
    发明申请
    Introducer Handle Notch Design/Concept 有权
    介绍者处理凹槽设计/概念

    公开(公告)号：US20140025003A1

    公开(公告)日：2014-01-23

    申请号：US13555470

    申请日：2012-07-23

    申请人： Scott Kimmel ,  Nicholas Kampa ,  Mark Nelson ,  Blane Larson

    发明人： Scott Kimmel ,  Nicholas Kampa ,  Mark Nelson ,  Blane Larson

    IPC分类号： A61M25/01 ,  A61M29/00

    CPC分类号： A61M25/0043 ,  A61B17/34 ,  A61M25/0097 ,  A61M25/0668 ,  A61M29/00

    摘要： An improved splittable medical device introducer designed to introduce a medical device such as a lead or catheter, into a patient's vasculature without loss of blood or introduction of air is described. The introducer assembly is designed with a notch provided at the proximal end of the introducer housing. The notch, which may comprise a multitude of cross-sectional geometries, is designed to reduce the force required to separate the housing and the introducer sheath, thereby minimizing the possibility of unintentional dislodgement during separation. The notch also increases the repeatability and consistency of the amount of force required to separate the introducer housing and sheath.

    摘要翻译： 描述了一种改进的可分裂医疗装置导引器，其被设计成将诸如引线或导管的医疗装置引入病人的脉管系统中而不会损失血液或引入空气。 导引器组件设计成具有设置在导引器壳体的近端处的凹口。 可以包括多个横截面几何形状的凹口被设计成减小分离壳体和导引器鞘所需的力，从而最小化在分离期间意外移动的可能性。 切口还增加了分离导引器壳体和护套所需的力的重复性和一致性。

    Facial recognition for document and application data access control
    10.
    发明授权
    Facial recognition for document and application data access control 有权
    文档和应用程序数据访问控制的面部识别

    公开(公告)号：US08601573B2

    公开(公告)日：2013-12-03

    申请号：US12561639

    申请日：2009-09-17

    申请人： Mark Nelson ,  Kevin H. Peters ,  Louis R. Ruggiero

    发明人： Mark Nelson ,  Kevin H. Peters ,  Louis R. Ruggiero

    IPC分类号： G06F7/04 ,  G06F21/62

    CPC分类号： G06F21/6218 ,  G06F21/32 ,  G06F21/84 ,  G06F2221/2101 ,  G07C9/00158

    摘要： A presentation system including a computing device, a display device coupled to the computing device and an image capture device that obtains an image containing facial images of at least two individuals capable of viewing the display device, the at least two individuals including a primary user and at least one secondary user, is provided. The system also includes a recognition apparatus operably coupled to the computing device and including a permission engine, the permission engine applying a policy to a protected information element displayed on the display screen, the policy causing one or more actions to be taken based on the identify of the primary and one or more of the secondary users.

    摘要翻译： 一种呈现系统，包括计算设备，耦合到所述计算设备的显示设备和获得包含能够观看所述显示设备的至少两个人的面部图像的图像的图像捕获设备，所述至少两个人包括主用户和 提供至少一个次要用户。 该系统还包括可操作地耦合到计算设备的识别设备，并且包括权限引擎，许可引擎将策略应用于显示在显示屏幕上的受保护信息元素，该策略导致基于识别的一个或多个动作 的主要和一个或多个次要用户。