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    Quinazolinone containing pharmaceutical compositions for prevention of neovascularization and for treating malignancies
    1.
    发明授权
    Quinazolinone containing pharmaceutical compositions for prevention of neovascularization and for treating malignancies 失效
    含喹唑啉酮的药物组合物，用于预防新血管形成和治疗恶性肿瘤

    公开(公告)号：US6028075A

    公开(公告)日：2000-02-22

    申请号：US797703

    申请日：1997-02-11

    申请人： Mark Pines ,  Israel Vlodavsky ,  Arnon Nagler ,  Hua-Quan Miao

    发明人： Mark Pines ,  Israel Vlodavsky ,  Arnon Nagler ,  Hua-Quan Miao

    IPC分类号： C07D401/06 ,  A61K31/517 ,  A61P35/00 ,  A61P43/00 ,  A61K31/505

    CPC分类号： A61K31/517

    摘要： The invention provides a composition for attenuating neovascularization and treating malignancies, including a pharmaceutically effective amount of a compound having a formula: ##STR1## wherein: R.sub.1 is a member of the group consisting of hydrogen, halogen, nitro, benzo, lower alkyl, phenyl and lower alkoxy;R.sub.2 is a member of the group consisting of hydroxy, acetoxy, and lower alkoxy, andR.sub.3 is a member of the group consisting of hydrogen and lower alkenoxy carbonyl;as active ingredient therein, in combination with a pharmaceutically acceptable carrier.

    摘要翻译： 本发明提供用于减毒新生血管形成和治疗恶性肿瘤的组合物，包括药学有效量的具有下式的化合物：其中：R 1是氢，卤素，硝基，苯并，低级烷基，苯基和低级烷氧基 ; R2是由羟基，乙酰氧基和低级烷氧基组成的组的成员，R3是由氢和低级链烯氧基羰基组成的组的成员; 作为其中的活性成分，与药学上可接受的载体组合。

    Neuropilins and use thereof in methods for diagnosis and prognosis of cancer
    3.
    发明授权
    Neuropilins and use thereof in methods for diagnosis and prognosis of cancer 有权
    神经胶质蛋白及其在癌症诊断和预后方法中的应用

    公开(公告)号：US06635421B1

    公开(公告)日：2003-10-21

    申请号：US09583638

    申请日：2000-05-30

    申请人： Michael Klagsbrun ,  Shay Soker ,  Hua-Quan Miao ,  Seiji Takashima

    发明人： Michael Klagsbrun ,  Shay Soker ,  Hua-Quan Miao ,  Seiji Takashima

    IPC分类号： C12Q168

    CPC分类号： C07K14/71 ,  A61K38/00 ,  A61K48/00

    摘要： The present invention relates to VEGF receptors (VEGFR) and neuropilins such as VEGF165R/NP-1 and NP-2 that are associated with metastatic potential of a malignant cell and their use in the diagnosis and prognosis of cancer. Preferred ones are VEGF165R/NP-1 and NP-2 but any neuropilin or VEGFR, where the constituents share at least about 85% homology with either of the above VEGF165R/NP-1 and NP-2 can be used. More preferably, such constituent shares at least 90% homology. Still more preferably, each constituent shares at least 95% homology.

    摘要翻译： 本发明涉及与恶性细胞转移潜能相关的VEGF受体（VEGFR）和神经胶质蛋白如VEGF165R / NP-1和NP-2及其在诊断和预后中的用途。 优选的是VEGF165R / NP-1和NP-2，但是可以使用任何神经蛋白或VEGFR，其中组分与上述VEGF165R / NP-1和NP-2中的任一个具有至少约85％的同源性。 更优选地，这样的成分具有至少90％的同源性。 更优选地，每个成分具有至少95％的同源性。