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15 条记录 (耗时 0.029 秒)

    PREPARATION OF RADIOLABELLED HALOAROMATICS VIA POLYMER-BOUND INTERMEDIATES
    6.
    发明申请
    PREPARATION OF RADIOLABELLED HALOAROMATICS VIA POLYMER-BOUND INTERMEDIATES 有权
    通过聚合物中间体制备无定形血红蛋白

    公开(公告)号：US20080085984A1

    公开(公告)日：2008-04-10

    申请号：US11850306

    申请日：2007-09-05

    申请人： Duncan Hunter ,  Xizhen Zhu

    发明人： Duncan Hunter ,  Xizhen Zhu

    IPC分类号： C08G79/12

    CPC分类号： C07C277/08 ,  A61K51/0406 ,  C07B2200/05 ,  C07C279/06

    摘要： According to a first aspect of the invention, a process is disclosed for the preparation of radiolabelled haloaromatic compounds. According to a second aspect of the invention, intermediate precursor insoluble polymer compounds used in the preparation of the radiolabelled haloaromatics are disclosed, as well as processes for the preparation of the intermediate precursor insoluble polymer compounds.

    摘要翻译： 根据本发明的第一方面，公开了制备放射性标记的卤代芳族化合物的方法。 根据本发明的第二方面，公开了用于制备放射性标记的卤代芳烃的中间体前体不溶性聚合物化合物，以及制备中间体前体不溶性聚合物化合物的方法。

    Preparation of radiolabelled haloaromatics via polymer-bound intermediates
    7.
    发明授权
    Preparation of radiolabelled haloaromatics via polymer-bound intermediates 有权
    通过聚合物结合的中间体制备放射性标记的卤代芳族化合物

    公开(公告)号：US06461585B1

    公开(公告)日：2002-10-08

    申请号：US09529017

    申请日：2000-07-18

    申请人： Duncan H. Hunter ,  Xizhen Zhu

    发明人： Duncan H. Hunter ,  Xizhen Zhu

    IPC分类号： A61K5100

    CPC分类号： C07C277/08 ,  A61K51/0406 ,  C07B2200/05 ,  C07C279/06

    摘要： According to a first aspect of the invention, a process is disclosed for the preparation of radiolabelled haloaromatic compounds. According to a second aspect of the invention, intermediate precursor insoluble polymer compounds used in the preparation of the radiolabelled haloaromatic are disclosed, as well as processes for the preparation of the intermediate precursor insoluble polymer compounds.

    摘要翻译： 根据本发明的第一方面，公开了制备放射性标记的卤代芳族化合物的方法。 根据本发明的第二方面，公开了用于制备放射性标记的卤代芳族化合物的中间体前体不溶性聚合物化合物，以及制备中间体前体不溶性聚合物化合物的方法。

    Preparation of radiolabelled haloaromatics via polymer-bound intermediates
    8.
    发明授权
    Preparation of radiolabelled haloaromatics via polymer-bound intermediates 有权
    通过聚合物结合的中间体制备放射性标记的卤代芳族化合物

    公开(公告)号：US07658910B2

    公开(公告)日：2010-02-09

    申请号：US11850306

    申请日：2007-09-05

    申请人： Duncan H. Hunter ,  Xizhen Zhu

    发明人： Duncan H. Hunter ,  Xizhen Zhu

    IPC分类号： A61K51/00

    CPC分类号： C07C277/08 ,  A61K51/0406 ,  C07B2200/05 ,  C07C279/06

    摘要： According to a first aspect of the invention, a process is disclosed for the preparation of radiolabelled haloaromatic compounds. According to a second aspect of the invention, intermediate precursor insoluble polymer compounds used in the preparation of the radiolabelled haloaromatics are disclosed, as well as processes for the preparation of the intermediate precursor insoluble polymer compounds.

    摘要翻译： 根据本发明的第一方面，公开了制备放射性标记的卤代芳族化合物的方法。 根据本发明的第二方面，公开了用于制备放射性标记的卤代芳烃的中间体前体不溶性聚合物化合物，以及制备中间体前体不溶性聚合物化合物的方法。

    Substituted phenoxy thiazolidinediones as estrogen related receptor-á modulators
    9.
    发明授权
    Substituted phenoxy thiazolidinediones as estrogen related receptor-á modulators 有权
    取代苯氧基噻唑烷二酮作为雌激素相关受体α调节剂

    公开(公告)号：US08344009B2

    公开(公告)日：2013-01-01

    申请号：US12899812

    申请日：2010-10-07

    申请人： Michael Gaul ,  Alexander Kim ,  Lily Lee Searle ,  Raymond Patch ,  Dionisois Rentzeperis ,  Guozhang Xu ,  Xizhen Zhu

    发明人： Michael Gaul ,  Alexander Kim ,  Lily Lee Searle ,  Raymond Patch ,  Dionisois Rentzeperis ,  Guozhang Xu ,  Xizhen Zhu

    IPC分类号： A61K31/426 ,  C07D277/04

    CPC分类号： C07D277/34 ,  C07D263/44

    摘要： The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but not limited to ankylosing spondylitis, artherosclerosis, arthritis (such as rheumatoid arthritis, infectious arthritis, childhood arthritis, psoriatic arthritis, reactive arthritis), bone-related diseases (including those related to bone formation), breast cancer (including those unresponsive to anti-estrogen therapy), cardiovascular disorders, cartilage-related disease (such as cartilage injury/loss, cartilage degeneration, and those related to cartilage formation), chondrodysplasia, chondrosarcoma, chronic back injury, chronic bronchitis, chronic inflammatory airway disease, chronic obstructive pulmonary disease, diabetes, disorders of energy homeostasis, gout, pseudogout, lipid disorders, metabolic syndrome, multiple myeloma, obesity, osteoarthritis, osteogenesis imperfecta, osteolytic bone metastasis, osteomalacia, osteoporosis, Paget's disease, periodontal disease, polymyalgia rheumatica, Reiter's syndrome, repetitive stress injury, hyperglycemia, elevated blood glucose level, and insulin resistance.

    摘要翻译： 本发明涉及式（I）化合物，制备这些化合物的方法，组合物，中间体及其衍生物，用于治疗包括但不限于强直性脊柱炎，动脉粥样硬化，关节炎（如类风湿性关节炎，感染性关节炎，儿童期 关节炎，牛皮癣关节炎，反应性关节炎），骨相关疾病（包括与骨形成相关的疾病），乳腺癌（包括对抗雌激素治疗无反应的那些），心血管疾病，软骨相关疾病（如软骨损伤/损失， 软骨变性和与软骨形成相关的软骨变性，软骨发育不全，软骨肉瘤，慢性背部损伤，慢性支气管炎，慢性炎症性气道疾病，慢性阻塞性肺病，糖尿病，能量稳态障碍，痛风，假性血糖，脂质障碍，代谢综合征，多发性 骨髓瘤，肥胖症，骨关节炎，成骨不全，骨质溶解骨 骨质疏松症，骨质疏松症，佩吉特氏病，牙周病，风湿性多肌痛，莱特综合征，重复性应激损伤，高血糖，升高的血糖水平和胰岛素抵抗。

    PREPARATION OF RADIOLABELLED HALOAROMATICS VIA POLYMER-BOUND INTERMEDIATES
    10.
    发明申请
    PREPARATION OF RADIOLABELLED HALOAROMATICS VIA POLYMER-BOUND INTERMEDIATES 审中-公开
    通过聚合物中间体制备无定形血红蛋白

    公开(公告)号：US20100274052A1

    公开(公告)日：2010-10-28

    申请号：US12702009

    申请日：2010-02-08

    申请人： Duncan H. Hunter ,  Xizhen Zhu

    发明人： Duncan H. Hunter ,  Xizhen Zhu

    IPC分类号： C07C279/02

    CPC分类号： C07C277/08 ,  A61K51/0406 ,  C07B2200/05 ,  C07C279/06

    摘要： According to a first aspect of the invention, a process is disclosed for the preparation of radiolabelled haloaromatic compounds. According to a second aspect of the invention, intermediate precursor insoluble polymer compounds used in the preparation of the radiolabelled haloaromatics are disclosed, as well as processes for the preparation of the intermediate precursor insoluble polymer compounds.

    摘要翻译： 根据本发明的第一方面，公开了制备放射性标记的卤代芳族化合物的方法。 根据本发明的第二方面，公开了用于制备放射性标记的卤代芳烃的中间体前体不溶性聚合物化合物，以及制备中间体前体不溶性聚合物化合物的方法。