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公开(公告)号:US06645978B1
公开(公告)日:2003-11-11
申请号:US09787789
申请日:2001-03-23
IPC分类号: A61K900
CPC分类号: A61K31/202 , A61K9/0048 , A61K31/557 , Y10S514/822 , Y10S514/925 , Y10S514/947 , Y10S514/954
摘要: Ophthalmic compositions containing Lipoxin A4 and its analogs and methods of their use for treating dry eve are disclosed.
摘要翻译: 公开了含有Lipoxin A4及其类似物的眼科组合物及其用于治疗干燥前夕的方法。
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2.15-Hydroxyeicosatetraenoic acid-related compounds and methods of use 失效
标题翻译: 15-羟基二十碳四烯酸相关化合物及其使用方法公开(公告)号:US06353012B1
公开(公告)日:2002-03-05
申请号:US09694713
申请日:2000-10-23
IPC分类号: A61K3141
摘要: HETE derivatives and methods of their use for treating dry eye are disclosed.
摘要翻译: 公开了HETE衍生物及其用于治疗干眼症的方法
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公开(公告)号:US20110207809A1
公开(公告)日:2011-08-25
申请号:US13034889
申请日:2011-02-25
申请人: Eric C. Carlson , Daniel A. Gamache , Mark R. Hellberg , Peter G. Klimko , Kerry L. Markwardt , John M. Yanni
发明人: Eric C. Carlson , Daniel A. Gamache , Mark R. Hellberg , Peter G. Klimko , Kerry L. Markwardt , John M. Yanni
IPC分类号: A61K31/366 , A61K31/16 , A61K31/191 , A61K31/22 , A61P27/02
CPC分类号: C07D309/30 , A61K9/0048 , A61K31/047 , A61K31/16 , A61K31/191 , A61K31/22 , A61K31/366 , C07C59/105 , C07C69/675 , C07C235/06
摘要: The topical ophthalmic use of 5,6,7-trihydroxyheptanoic acid and analogs for the acceleration of corneal wound healing in humans, is disclosed.
摘要翻译: 公开了5,6,7-三羟基庚酸及其类似物在人体中加速角膜伤口愈合的局部眼用。
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公开(公告)号:US20120015953A1
公开(公告)日:2012-01-19
申请号:US13183194
申请日:2011-07-14
IPC分类号: A61K31/4985 , C12Q1/28 , A61P27/14 , A61K31/335 , A61K31/519
CPC分类号: A61K31/335 , A61K9/0048 , A61K31/4985 , A61K31/519 , A61K45/06 , C07D487/04 , A61K2300/00
摘要: The present invention relates to compositions comprising an antagonist of the histamine H1 receptor and a compatible antagonist of the histamine H4 receptor. The antagonist compounds are selected to prevent the H4 receptor antagonist from interfering with the H1 receptor antagonist's suppression of acute phase allergic responses in a patient. The present invention also relates to compositions comprising a mast cell stabilizer and a compatible antagonist of the histamine H4 receptor.
摘要翻译: 本发明涉及包含组胺H1受体的拮抗剂和组胺H 4受体的相容拮抗剂的组合物。 选择拮抗剂化合物以防止H4受体拮抗剂干扰H1受体拮抗剂抑制患者的急性期过敏反应。 本发明还涉及包含肥大细胞稳定剂和组胺H 4受体的相容拮抗剂的组合物。
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公开(公告)号:US20110130451A1
公开(公告)日:2011-06-02
申请号:US13022692
申请日:2011-02-08
IPC分类号: A61K31/351 , A61K31/191 , A61K31/22 , A61P27/02
CPC分类号: A61K31/22 , A61K31/047 , A61K31/366
摘要: The topical use of 5,6,7-trihydroxyheptanoic acid and analogs are disclosed for the treatment of dry eye disorders and uveitis.
摘要翻译: 公开了5,6,7-三羟基庚酸及其类似物的局部用途,用于治疗干眼症和葡萄膜炎。
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公开(公告)号:US07923471B2
公开(公告)日:2011-04-12
申请号:US11268301
申请日:2005-11-07
IPC分类号: A01N37/02 , A01N31/00 , A61K31/22 , A61K31/045
CPC分类号: A61K31/22 , A61K31/047 , A61K31/366
摘要: The topical use of 5,6,7-trihydroxyheptanoic acid and analogs are disclosed for the treatment of dry eye disorders and uveitis.
摘要翻译: 公开了5,6,7-三羟基庚酸及其类似物的局部用途,用于治疗干眼症和葡萄膜炎。
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7.5,6,7-trihydroxyheptanoic acid and analogs for the treatment of ocular diseases and diseases associated with hyperproliferative and angiogenic responses 有权
标题翻译: 5,6,7-三羟基庚酸和类似物,用于治疗眼部疾病和与过度增生和血管生成反应相关的疾病公开(公告)号:US07879905B2
公开(公告)日:2011-02-01
申请号:US11268968
申请日:2005-11-08
CPC分类号: A61K31/047 , A61K9/0048 , A61K31/20 , A61K31/22 , A61K31/366
摘要: Compositions containing 5,6,7-trihydroxyheptanoic acid and analogs and their use for treating posterior segment ocular diseases and diseases characterized by cellular hyperproliferation or angiogenesis, are disclosed.
摘要翻译: 公开了含有5,6,7-三羟基庚酸及其类似物的组合物及其用于治疗后段眼部疾病和以细胞过度增殖或血管发生为特征的疾病的用途。
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公开(公告)号:US20100081646A1
公开(公告)日:2010-04-01
申请号:US12544185
申请日:2009-08-19
申请人: Steven P. Govek , Clay Beauregard , Daniel A. Gamache , Mark R. Hellberg , Stewart A. Noble , Andrew K. Shiau , David J. Thomas , John M. Yanni
发明人: Steven P. Govek , Clay Beauregard , Daniel A. Gamache , Mark R. Hellberg , Stewart A. Noble , Andrew K. Shiau , David J. Thomas , John M. Yanni
IPC分类号: A61K31/551 , C07D401/12 , C07D413/14 , C07D401/14 , A61K31/4709 , A61K31/497 , A61K31/5377 , A61P27/02 , A61P37/00
CPC分类号: A61K31/4704 , A61K31/4709 , A61K31/497 , A61K31/5377 , A61K31/551 , A61K45/06 , C07D401/12 , A61K2300/00
摘要: The present invention relates to compounds and methods which may be useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
摘要翻译: 本发明涉及可用作磷酸二酯酶4(PDE4)抑制剂的化合物和方法,用于治疗或预防炎性疾病和涉及升高的细胞因子和促炎介质水平的其它疾病。
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公开(公告)号:US20130045975A1
公开(公告)日:2013-02-21
申请号:US13370756
申请日:2012-02-10
申请人: Steven P. Govek , Clay Beauregard , Daniel A. Gamache , Mark R. Hellberg , Stewart A. Noble , Andrew K. Shiau , David J. Thomas , John M. Yanni
发明人: Steven P. Govek , Clay Beauregard , Daniel A. Gamache , Mark R. Hellberg , Stewart A. Noble , Andrew K. Shiau , David J. Thomas , John M. Yanni
IPC分类号: A61K31/4709 , C07D401/14 , A61K31/496 , C07D413/14 , A61K31/5377 , A61K31/551 , A61P27/02 , A61P27/14 , A61P27/04 , A61P27/06 , A61P29/00 , A61P9/10 , A61P25/00 , A61P37/08 , C07D401/12
CPC分类号: A61K31/4704 , A61K31/4709 , A61K31/497 , A61K31/5377 , A61K31/551 , A61K45/06 , C07D401/12 , A61K2300/00
摘要: The present invention relates to compounds and methods which may be useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
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公开(公告)号:US08138205B2
公开(公告)日:2012-03-20
申请号:US12544185
申请日:2009-08-19
申请人: Steven P. Govek , Clay Beauregard , Daniel A. Gamache , Mark R. Hellberg , Stewart A. Noble , Andrew K. Shiau , David J. Thomas , John M. Yanni
发明人: Steven P. Govek , Clay Beauregard , Daniel A. Gamache , Mark R. Hellberg , Stewart A. Noble , Andrew K. Shiau , David J. Thomas , John M. Yanni
IPC分类号: A61K31/47 , C07D401/12
CPC分类号: A61K31/4704 , A61K31/4709 , A61K31/497 , A61K31/5377 , A61K31/551 , A61K45/06 , C07D401/12 , A61K2300/00
摘要: The present invention relates to compounds and methods which may be useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
摘要翻译: 本发明涉及可用作磷酸二酯酶4(PDE4)抑制剂的化合物和方法,用于治疗或预防炎性疾病和涉及升高的细胞因子和促炎介质水平的其它疾病。
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