公开(公告)号：US11971415B2

公开(公告)日：2024-04-30

申请号：US17259361

申请日：2019-06-20

申请人： Siemens Healthcare Diagnostics Inc.

发明人： Aaron Kauffmann

IPC分类号： G01N33/58 ,  B01L3/00 ,  G01N33/70

CPC分类号： G01N33/58 ,  B01L3/502 ,  G01N33/70 ,  B01L2300/16 ,  B01L2400/0406

摘要： Devices, kits, and methods related to embodiments of an improved liquid test sample injection device comprising a sample mixture that comprises at least one sample flag compound for detecting the presence or non-presence of a patient's liquid test sample upon being interrogated by a pre-determined wavelength of light.

公开(公告)号：US11965854B2

公开(公告)日：2024-04-23

申请号：US17509485

申请日：2021-10-25

申请人： Radiometer Medical ApS

发明人： Thomas Kjaer

IPC分类号： G01N27/327 ,  C12Q1/00 ,  G01N33/70

CPC分类号： G01N27/3274 ,  C12Q1/005 ,  G01N33/70 ,  G01N2333/90683 ,  G01N2333/986

摘要： A method of calibrating a device for measuring the concentration of creatinine using one or more calibration solutions, the method comprising: receiving concentrations at an initial time of creatine, Cr, and/or creatinine, Crn, of the one or more calibration solutions; receiving outputs of the measuring device at the end time; calculating the concentration of Cr and/or Crn in the calibration solutions at an end time using a temperature model, wherein the temperature model indicates changes in temperature of the calibration solutions from the initial time to the end time; and determining a relationship between the outputs of the measuring device and the calculated concentrations of Cr and/or Crn.

公开(公告)号：US20240077469A1

公开(公告)日：2024-03-07

申请号：US18272337

申请日：2022-01-14

申请人： Aurinia Pharmaceuticals Inc.

发明人： Michael MARTIN ,  Robert B. HUIZINGA ,  Neil SOLOMONS

IPC分类号： G01N33/50 ,  A61K31/5377 ,  A61K31/573 ,  A61P13/12 ,  G01N33/62 ,  G01N33/68 ,  G01N33/70 ,  G01N33/92

CPC分类号： G01N33/5008 ,  A61K31/5377 ,  A61K31/573 ,  A61P13/12 ,  G01N33/62 ,  G01N33/6893 ,  G01N33/70 ,  G01N33/92 ,  G01N2800/24 ,  G01N2800/347 ,  G01N2800/52

摘要： Provided herein are methods of employing pharmacodynamics regimens to maximize effectiveness of voclosporin in treatment of proteinuric kidney diseases while minimizing undesirable side effects, such as but not limited to calcineurin inhibitor nephrotoxicity. Also provided are methods of assessments of renal functions and/or conditions, and corresponding protocols to modify, stop, restore and/or re-initiate voclosporin dosing and administrations to maximize effectiveness of voclosporin in treatment of proteinuric kidney diseases while minimizing undesirable side effects.

公开(公告)号：US20230384328A1

公开(公告)日：2023-11-30

申请号：US17751741

申请日：2022-05-24

申请人： Zhongshan BGH Biochem Co., Ltd.

发明人： Yongbiao Yu

IPC分类号： G01N33/70

CPC分类号： G01N33/70

摘要： Provided is a creatinine assay kit with desirable stability and capable of rapidly eliminating drug interference. The creatinine assay kits include a first reagent R1 and a second reagent R2. The first reagent R1 comprises a first buffer solution, creatinase, sarcosine oxidase, ascorbic acid oxidase, peroxidase or catalase, serum albumin, a first non-ionic surfactant, a first preservative, Trinder's reactant A, laccase, a metal salt, or a combination thereof. The second reagent R2 comprises a second buffer solution, serum albumin, creatininase, a second preservative, Trinder's reactant B, or a combination thereof. The creatinine assay kits eliminate or significantly reduce inaccurate creatinine determination due to negative deviation caused by serum samples containing calcium dobesilate and/or etamsylate.

公开(公告)号：US20230366828A1

公开(公告)日：2023-11-16

申请号：US18135882

申请日：2023-04-18

申请人： Kiran R. Tremblay ,  Lonna Y. Neidig ,  Alexandra M. Gannon ,  Burnon J. Chen

发明人： Kiran R. Tremblay ,  Lonna Y. Neidig ,  Alexandra M. Gannon ,  Burnon J. Chen

IPC分类号： G01N21/78 ,  G01N33/573 ,  G01N33/70

CPC分类号： G01N21/78 ,  G01N33/573 ,  G01N33/70 ,  G01N2333/912

摘要： An inexpensive test device compares and contrasts a plurality of pigmented tests for a biomarker, organism or other substance for a relative presence of each. Each biomarker is present in a urine sample, and the pigmented test renders a color shade indicative of a respective proportion or quantity. Collection of the pigmented test results in a series of transparent vials allowing a common line of sight through each vial to result in an appearance of a blended or combined color, similar to viewing color filters in line. A predetermined control group of color combinations provides a comparison for respective concentrations of each biomarker present in the sample. In one approach, a first pigmented test results in an orange-yellow shade and a second pigmented test results in a blue shade that, when viewed inline, appear as a green, brown or purple shade indicative of relative percentages denoted by each respective test.

公开(公告)号：US11753680B2

公开(公告)日：2023-09-12

申请号：US17738988

申请日：2022-05-06

申请人： The Regents of the University of California

发明人： Minnie M. Sarwal ,  Tara K. Sigdel ,  Joshua Y. Yang

IPC分类号： C12Q1/6883 ,  G01N33/70 ,  G01N33/68 ,  G01N33/53 ,  C12Q1/6853 ,  C12Q1/6827 ,  G16H10/40 ,  C12Q1/6813 ,  C12Q1/6876

CPC分类号： C12Q1/6853 ,  C12Q1/6813 ,  C12Q1/6827 ,  C12Q1/6876 ,  C12Q1/6883 ,  G01N33/53 ,  G01N33/68 ,  G01N33/6827 ,  G01N33/6839 ,  G16H10/40 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/154 ,  C12Q2600/158 ,  G01N33/70 ,  G01N2800/245 ,  G01N2800/347

摘要： Provided herein is the use of measurements of cell-free DNA, protein, and/or metabolite found in biofluid (e.g., urine) for identifying and treating organ injury. Provided herein are methods and compositions for monitoring, detecting, quantifying, and treating kidney injury in subjects suffering from or suspected of having an altered renal status by measuring amounts of cfDNA and one or more other markers, such as inflammation markers, apoptosis markers, protein, and DNA methylation.

公开(公告)号：US11674923B2

公开(公告)日：2023-06-13

申请号：US16603441

申请日：2018-03-20

申请人： UNIVERSITÄT INNSBRUCK ,  MEDIZINISCHE UNIVERSITÄT INNSBRUCK

发明人： Peter Heinz-Erian ,  Gerda Laura Fuhrmann

IPC分类号： G01N27/333 ,  A61B10/00 ,  G01N27/327 ,  G01N33/70

CPC分类号： G01N27/333 ,  A61B10/007 ,  G01N27/3275 ,  G01N33/70

摘要： The present invention relates to a single-use test-strip for the quantitative determination of sodium concentration and creatinine concentration and for the subsequent determination of their ratio, and to a non-invasive point-of-care (POC) device for detecting sodium depletion and/or sodium overload in a patient's body. Furthermore, the present invention relates to a method for simultaneously and quantitatively determining sodium concentration and creatinine concentration in a patient's urine sample and to a method of detecting sodium depletion and/or sodium overload in a patient's body.

公开(公告)号：US20230176079A1

公开(公告)日：2023-06-08

申请号：US18078688

申请日：2022-12-09

申请人： Jana Care, Inc.

发明人： Daniel B. Lookadoo ,  Ashok A. Kumar ,  Jeremy E. Schonhorn ,  Christopher M. Uherek ,  Michal Depa

IPC分类号： G01N33/70 ,  G01N33/68 ,  H04W84/18 ,  G16C20/10 ,  G01N33/535 ,  G01N35/00

CPC分类号： G01N33/70 ,  G01N33/6893 ,  H04W84/18 ,  G16C20/10 ,  G01N33/535 ,  G01N35/00069

摘要： Platforms for enzymatic assays for biomarkers, including systems, methods, and measuring devices by which a biomarker, such as creatinine, is measured using a small amount of biological fluid, such as blood, plasma, or serum. The measuring device or biosensor can be a test strip including a layered active component assembly positioned between two outer layers which enables multi-step enzymatic reactions operating in kinetic and/or endpoint (in which the reaction is allowed to near completion), and generally includes multiple layers with primary enzyme(s), coupling enzyme(s), and reagents to produce an optical signal correlated to the concentration of a biomarker in the sample. The test strip can be read using a portable optical reader coupled to a smart phone or tablet.

公开(公告)号：US10000784B2

公开(公告)日：2018-06-19

申请号：US15509067

申请日：2015-09-01

申请人： Siemens Healthcare Diagnostics Inc.

发明人： Wei Zhang ,  Jingzhong Zhang

IPC分类号： C12Q1/00 ,  B82Y30/00 ,  G01N27/26

CPC分类号： C12Q1/002 ,  B82Y30/00 ,  C12Q1/001 ,  C12Q1/005 ,  G01N27/26 ,  G01N27/3335 ,  G01N27/4035 ,  G01N33/70

摘要： This disclosure relates to creatinine biosensors and the uses thereof. More specifically, this disclosure describes potentiometric creatinine sensors which utilizes one or both of a type of enzyme capable of directly producing ammonium ions (NH4+) as a consequence of coming into contact with a liquid sample and an internal fill solution with a low free ammonium ion concentration.

公开(公告)号：US20170363567A1

公开(公告)日：2017-12-21

申请号：US15536309

申请日：2015-12-17

申请人： Radiometer Medical ApS

发明人： Thomas KJAER

IPC分类号： G01N27/327 ,  G01N33/70

CPC分类号： G01N27/3274 ,  G01N33/70 ,  G01N2333/986

摘要： A method of calibrating a device for measuring the concentration of creatinine using one or more calibration solutions, the method comprising: receiving concentrations at an initial time of creatine, Cr, and/or creatinine, Crn, of the one or more calibration solutions; receiving outputs of the measuring device at the end time; calculating the concentration of Cr and/or Crn in the calibration solutions at an end time using a temperature model, wherein the temperature model indicates changes in temperature of the calibration solutions from the initial time to the end time; and determining a relationship between the outputs of the measuring device and the calculated concentrations of Cr and/or Crn.