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公开(公告)号:US08501184B2
公开(公告)日:2013-08-06
申请号:US12949846
申请日:2010-11-19
IPC分类号: A61K39/395 , C07K16/00 , C12P21/08
CPC分类号: C07K16/40 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12Y304/21061
摘要: An human antibody or antigen-binding fragment of a human antibody that specifically binds and inhibits human proprotein convertase subtilisin/kexin type 9 (hPCSK9) characterized by the ability to reduce serum LDL cholesterol by 40-80% over a 24, 60 or 90 day period relative to predose levels, with little or no reduction in serum HDL cholesterol and/or with little or no measurable effect on liver function, as determined by ALT and AST measurements.
摘要翻译: 特异性结合并抑制人前体蛋白转化酶枯草杆菌蛋白酶/ kexin 9型(hPCSK9)的人抗体的人抗体或抗原结合片段,其特征在于能够在24,60或90天将血清LDL胆固醇降低40-80% 相对于前期水平,血清HDL胆固醇几乎没有或没有降低和/或通过ALT和AST测量确定对肝功能具有很小或没有可测量的影响。
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公开(公告)号:US20110065902A1
公开(公告)日:2011-03-17
申请号:US12949846
申请日:2010-11-19
IPC分类号: C07K16/40
CPC分类号: C07K16/40 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12Y304/21061
摘要: An human antibody or antigen-binding fragment of a human antibody that specifically binds and inhibits human proprotein convertase subtilisin/kexin type 9 (hPCSK9) characterized by the ability to reduce serum LDL cholesterol by 40-80% over a 24, 60 or 90 day period relative to predose levels, with little or no reduction in serum HDL cholesterol and/or with little or no measurable effect on liver function, as determined by ALT and AST measurements.
摘要翻译: 特异性结合并抑制人前体蛋白转化酶枯草杆菌蛋白酶/ kexin 9型(hPCSK9)的人抗体的人抗体或抗原结合片段,其特征在于能够在24,60或90天将血清LDL胆固醇降低40-80% 相对于前期水平,血清HDL胆固醇几乎没有或没有降低和/或通过ALT和AST测量确定对肝功能具有很小或没有可测量的影响。
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3.
公开(公告)号:US08357371B2
公开(公告)日:2013-01-22
申请号:US13095234
申请日:2011-04-27
IPC分类号: A61K39/395 , C07K16/00 , C12P21/08
CPC分类号: C07K16/40 , A61K31/40 , A61K39/3955 , A61K2039/505 , C07K2317/21 , C07K2317/76 , C07K2317/92 , C07K2317/94 , A61K2300/00
摘要: The present invention provides methods for treating hypercholesterolemia. The methods of the present invention comprise administering to a subject in need thereof a therapeutic composition comprising an anti-PCSK9 antibody or antigen-binding fragment thereof.
摘要翻译: 本发明提供治疗高胆固醇血症的方法。 本发明的方法包括向有需要的受试者施用包含抗PCSK9抗体或其抗原结合片段的治疗组合物。
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公开(公告)号:US20100166768A1
公开(公告)日:2010-07-01
申请号:US12637942
申请日:2009-12-15
IPC分类号: A61K39/395 , C07K16/40 , C07H21/04 , C12N15/63 , C12P21/06
CPC分类号: C07K16/40 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12Y304/21061
摘要: An human antibody or antigen-binding fragment of a human antibody that specifically binds and inhibits human proprotein convertase subtilisin/kexin type 9 (hPCSK9) characterized by the ability to reduce serum LDL cholesterol by 40-80% over a 24, 60 or 90 day period relative to predose levels, with little or no reduction in serum HDL cholesterol and/or with little or no measurable effect on liver function, as determined by ALT and AST measurements.
摘要翻译: 特异性结合并抑制人前体蛋白转化酶枯草杆菌蛋白酶/ kexin 9型(hPCSK9)的人抗体的人抗体或抗原结合片段,其特征在于能够在24,60或90天将血清LDL胆固醇降低40-80% 相对于前期水平,血清HDL胆固醇几乎没有或没有降低和/或通过ALT和AST测量确定对肝功能具有很小或没有可测量的影响。
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5.
公开(公告)号:US20120258098A1
公开(公告)日:2012-10-11
申请号:US13462938
申请日:2012-05-03
申请人: Allen Radin , Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Eric Smith , Kevin J. Pobursky , Nicholas J. Papadopoulos , James P. Fandl , Gang Chen , Margaret Karow
发明人: Allen Radin , Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Eric Smith , Kevin J. Pobursky , Nicholas J. Papadopoulos , James P. Fandl , Gang Chen , Margaret Karow
IPC分类号: A61K39/395 , A61P29/00
CPC分类号: A61K39/3955 , A61K31/4706 , A61K31/519 , A61K31/655 , A61K38/191 , A61K39/39541 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/248 , C07K16/2866 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , Y10S514/885 , A61K2300/00
摘要: The present invention provides methods of preventing or treating rheumatoid arthritis using a fully human antibody or antigen-binding fragment thereof that specifically binds human interleukin-6 receptor (hIL-6R). The methods of the present invention may include administration of a second therapeutic agent, such as one or more of a non-steroidal anti-inflammatory drug (NSAID), a glucocorticoid, a disease-modifying anti-rheumatic drug (DMARD), or a TNF-alpha antagonist, T-cell blocker, anti-CD20 antibody, an IL-1, JAK or IL-17 antagonist, or any combination thereof.
摘要翻译: 本发明提供使用特异性结合人白细胞介素-6受体(hIL-6R)的完全人抗体或其抗原结合片段预防或治疗类风湿性关节炎的方法。 本发明的方法可以包括施用第二治疗剂,例如非甾体抗炎药(NSAID),糖皮质激素,疾病缓解性抗风湿药(DMARD)中的一种或多种,或 TNF-α拮抗剂,T细胞阻断剂,抗CD20抗体,IL-1,JAK或IL-17拮抗剂或其任何组合。
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6.
公开(公告)号:US20120045440A1
公开(公告)日:2012-02-23
申请号:US13286261
申请日:2011-11-01
申请人: Allen Radin , Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Eric Smith , Kevin J. Pobursky , Nicholas J. Papadopoulos , James P. Fandl , Gang Chen , Margaret Karow
发明人: Allen Radin , Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Eric Smith , Kevin J. Pobursky , Nicholas J. Papadopoulos , James P. Fandl , Gang Chen , Margaret Karow
IPC分类号: A61K39/395 , A61P19/02
CPC分类号: A61K39/3955 , A61K31/4706 , A61K31/519 , A61K31/655 , A61K38/191 , A61K39/39541 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/248 , C07K16/2866 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , Y10S514/885 , A61K2300/00
摘要: The present invention provides methods of preventing or treating rheumatoid arthritis using a fully human antibody or antigen-binding fragment thereof that specifically binds human interleukin-6 receptor (hIL-6R). The methods of the present invention may include administration of a second therapeutic agent, such as one or more of a non-steroidal anti-inflammatory drug (NSAID), a glucocorticoid, a disease-modifying anti-rheumatic drug (DMARD), or a TNF-alpha antagonist, T-cell blocker, anti-CD20 antibody, an IL-1, JAK or IL-17 antagonist, or any combination thereof.
摘要翻译: 本发明提供使用特异性结合人白细胞介素-6受体(hIL-6R)的完全人抗体或其抗原结合片段预防或治疗类风湿性关节炎的方法。 本发明的方法可以包括施用第二治疗剂,例如非甾体抗炎药(NSAID),糖皮质激素,疾病缓解性抗风湿药(DMARD)中的一种或多种,或 TNF-α拮抗剂,T细胞阻断剂,抗CD20抗体,IL-1,JAK或IL-17拮抗剂或其任何组合。
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公开(公告)号:US08092802B2
公开(公告)日:2012-01-10
申请号:US12821499
申请日:2010-06-23
申请人: Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Marcela Torres , Kevin J. Pobursky , Raymond W. Leidich , Joan A. Windsor , Warren R. Mikulka , Diana M. Ahrens , Ergang Shi , Nicholas J. Papadopoulos
发明人: Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Marcela Torres , Kevin J. Pobursky , Raymond W. Leidich , Joan A. Windsor , Warren R. Mikulka , Diana M. Ahrens , Ergang Shi , Nicholas J. Papadopoulos
IPC分类号: A61K39/00
CPC分类号: C07K16/2866 , A61K2039/505 , C07K2317/21 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要: The present invention provides methods for treating one or more diseases or disorders which are improved, inhibited or ameliorated by reducing interleukin-4 (IL-4) activity. The methods of the invention comprise administering to a patient an antibody, or antigen-binding fragment thereof, which specifically binds to a human IL-4 receptor.
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公开(公告)号:US08080248B2
公开(公告)日:2011-12-20
申请号:US12780006
申请日:2010-05-14
申请人: Allen Radin , Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Eric Smith , Kevin J. Pobursky , Nicholas J. Papadopoulos , James P. Fandl , Gang Chen , Margaret Karow
发明人: Allen Radin , Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Eric Smith , Kevin J. Pobursky , Nicholas J. Papadopoulos , James P. Fandl , Gang Chen , Margaret Karow
IPC分类号: A61K39/395
CPC分类号: A61K39/3955 , A61K31/4706 , A61K31/519 , A61K31/655 , A61K38/191 , A61K39/39541 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/248 , C07K16/2866 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , Y10S514/885 , A61K2300/00
摘要: The present invention provides methods of preventing or treating rheumatoid arthritis using a fully human antibody or antigen-binding fragment thereof that specifically binds human interleukin-6 receptor (hIL-6R). The methods of the present invention may include administration of a second therapeutic agent, such as one or more of a non-steroidal anti-inflammatory drug (NSAID), a glucocorticoid, a disease-modifying anti-rheumatic drug (DMARD), or a TNF-alpha antagonist, T-cell blocker, anti-CD20 antibody, an IL-1, JAK or IL-17 antagonist, or any combination thereof.
摘要翻译: 本发明提供使用特异性结合人白细胞介素-6受体(hIL-6R)的完全人抗体或其抗原结合片段预防或治疗类风湿性关节炎的方法。 本发明的方法可以包括施用第二治疗剂,例如非甾体抗炎药(NSAID),糖皮质激素,疾病缓解性抗风湿药(DMARD)中的一种或多种,或 TNF-α拮抗剂,T细胞阻断剂,抗CD20抗体,IL-1,JAK或IL-17拮抗剂或其任何组合。
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公开(公告)号:US07608693B2
公开(公告)日:2009-10-27
申请号:US12260307
申请日:2008-10-29
IPC分类号: C07K16/28
CPC分类号: C07K16/2866 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/76 , C07K2317/92
摘要: An isolated human antibody or antibody fragment thereof which binds to human interleukin-4 receptor alpha (hIL-4Rα) with high affinity (KD), capable of blocking hIL-4 and hIL-13 activity.
摘要翻译: 以高亲和力(KD)结合能够阻断hIL-4和hIL-13活性的人白细胞介素-4受体α(hIL-4Ralpha)的分离的人抗体或其抗体片段。
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公开(公告)号:US20090074793A1
公开(公告)日:2009-03-19
申请号:US12260307
申请日:2008-10-29
IPC分类号: A61K39/395 , C07K16/18 , C07H21/00 , C12N15/64 , A61P37/06 , C12N1/21 , C12N5/10 , C12P21/00
CPC分类号: C07K16/2866 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/76 , C07K2317/92
摘要: An isolated human antibody or antibody fragment thereof which binds to human interleukin-4 receptor alpha (hIL-4Rα) with high affinity (KD), capable of blocking hIL-4 and hIL-13 activity.
摘要翻译: 以高亲和力(KD)结合能够阻断hIL-4和hIL-13活性的人白细胞介素-4受体α(hIL-4Ralpha)的分离的人抗体或其抗体片段。
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