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公开(公告)号:US20070010526A1
公开(公告)日:2007-01-11
申请号:US10494424
申请日:2002-11-01
申请人: Markus Haeberlein , Christof Angst , Daniel Hill , Robert Jacobs , Gary Moore , Edward Pierson , Ashokkumar Shenvi
发明人: Markus Haeberlein , Christof Angst , Daniel Hill , Robert Jacobs , Gary Moore , Edward Pierson , Ashokkumar Shenvi
IPC分类号: A61K31/496 , A61K31/4709 , C07D403/02 , C07D401/02
CPC分类号: C07D401/04 , C07D217/04 , C07D217/06 , C07D401/12 , C07D405/06 , C07D413/10 , C07D413/12 , C07D417/12
摘要: Provided herein is a compound of the formula (I), wherein said compounds are useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating disorders, dementia, panic disorder, and sleep disorders. The compounds may also be useful in the treatment of gastrointestinal disorders, cardiovascular regulation, motor disorders, endocrine disorders, vasospasm and sexual dysfunction. The compounds are 5HT1B and 5HT1D antagonists.
摘要翻译: 本文提供了式(I)的化合物,其中所述化合物可用于治疗精神障碍,包括但不限于抑郁症,广泛性焦虑症,进食障碍,痴呆症,惊恐障碍和睡眠障碍。 该化合物还可用于治疗胃肠道疾病,心血管调节,运动障碍,内分泌障碍,血管痉挛和性功能障碍。 该化合物是5HT 1B和5HT 1D 1拮抗剂。
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公开(公告)号:US20090170851A1
公开(公告)日:2009-07-02
申请号:US12403553
申请日:2009-03-13
申请人: Peter Bernstein , Daniel Hill , David Nugiel , Edward Pierson , Ashokkumar Shenvi , Robert Jacobs
发明人: Peter Bernstein , Daniel Hill , David Nugiel , Edward Pierson , Ashokkumar Shenvi , Robert Jacobs
IPC分类号: A61K31/5377 , A61P25/22
CPC分类号: C07D311/66
摘要: Compounds according to Formula (I): wherein R1, R2, R3, and R4 are as defined in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.
摘要翻译: 根据式(I)的化合物:其中R 1,R 2,R 3和R 4如本说明书中所定义,药学上可接受的盐,制备方法,药物组合物及其使用方法。
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公开(公告)号:US20070185107A1
公开(公告)日:2007-08-09
申请号:US11592686
申请日:2006-11-03
申请人: Peter Bernstein , Daniel Hill , David Nugiel , Edward Pierson , Ashokkumar Shenvi , Robert Jacobs
发明人: Peter Bernstein , Daniel Hill , David Nugiel , Edward Pierson , Ashokkumar Shenvi , Robert Jacobs
IPC分类号: A61K31/5377 , A61K31/497 , C07D413/14 , C07D405/14
CPC分类号: C07D311/66
摘要: Compounds according to Formula (I): wherein R1, R2, R3, and R4 are as defined in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.
摘要翻译: 根据式(I)的化合物:其中R 1,R 2,R 3和R 4均为 如本说明书中所定义的药学上可接受的盐,制备方法,含药物组合物及其使用方法。
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公开(公告)号:US20060089346A1
公开(公告)日:2006-04-27
申请号:US10528640
申请日:2003-10-02
申请人: Christopher Becker , Bruce Dembofsky , Robert Jacobs , James Kang , Cyrus Ohnmacht , James Rosamond , Ashokkumar Shenvi , Thomas Simpson , James Woods
发明人: Christopher Becker , Bruce Dembofsky , Robert Jacobs , James Kang , Cyrus Ohnmacht , James Rosamond , Ashokkumar Shenvi , Thomas Simpson , James Woods
IPC分类号: A61K31/554 , A61K31/55 , A61K31/551
CPC分类号: C07K5/06034 , A61K38/00 , C07D223/16 , C07D267/10 , C07D267/14 , C07D281/06 , C07D281/10 , C07D405/04 , C07D417/12 , C07D417/14 , C07K5/06026 , C07K5/06191
摘要: Compounds having the formula (1) pharmaceutical compositions containing them and their methods of use for the treatment of neurological disorders related to amyloid B protein production and neurological disorders such as Alzheimer's disease. These compounds inhibit γ secretase and thereby inhibit the production of amyloid β protein, thereby acting to prevent the formation of neurological deposits of amyloid protein.
摘要翻译: 具有式(1)的药物组合物及其用于治疗与淀粉样蛋白B蛋白质产生和神经障碍如阿尔茨海默病相关的神经障碍的方法。 这些化合物抑制γ分泌酶,从而抑制淀粉样蛋白β蛋白的产生,从而起到防止淀粉样蛋白的神经沉积的形成的作用。
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公开(公告)号:US20080076752A1
公开(公告)日:2008-03-27
申请号:US11844451
申请日:2007-08-24
申请人: Christopher Becker , Bruce Dembofsky , Robert Jacobs , James Kang , Cyrus Ohnmacht , James Rosamond , Ashokkumar Shenvi , Thomas Simpson , James Woods
发明人: Christopher Becker , Bruce Dembofsky , Robert Jacobs , James Kang , Cyrus Ohnmacht , James Rosamond , Ashokkumar Shenvi , Thomas Simpson , James Woods
IPC分类号: A61K31/554 , A61P25/28
CPC分类号: C07K5/06034 , A61K38/00 , C07D223/16 , C07D267/10 , C07D267/14 , C07D281/06 , C07D281/10 , C07D405/04 , C07D417/12 , C07D417/14 , C07K5/06026 , C07K5/06191
摘要: Compounds having the formula (I) pharmaceutical compositions containing them and their methods of use for the treatment of neurological disorders related to amyloid β protein production and neurological disorders such as Alzheimer's disease. These compounds inhibit γ secretase and thereby inhibit the production of amyloid β protein, thereby acting to prevent the formation of neurological deposits of amyloid protein.
摘要翻译: 具有式(I)的药物组合物和含有它们的药物组合物及其用于治疗与淀粉样蛋白β蛋白生产和神经障碍如阿尔茨海默病有关的神经障碍的方法。 这些化合物抑制γ分泌酶,从而抑制淀粉样蛋白β蛋白的产生,从而起到防止淀粉样蛋白的神经沉积的形成的作用。
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公开(公告)号:US20070135442A1
公开(公告)日:2007-06-14
申请号:US11592543
申请日:2006-11-03
申请人: Peter Bernstein , Daniel Hill , Margaret Schooler , Ashok Shenvi , Robert Jacobs
发明人: Peter Bernstein , Daniel Hill , Margaret Schooler , Ashok Shenvi , Robert Jacobs
IPC分类号: A61K31/506 , A61K31/496 , C07D413/14 , C07D405/02
CPC分类号: C07D311/66 , C07D405/12 , C07D413/12
摘要: Compounds according to Formula (I) below: wherein R1, R2, R3, and R4 are as defined in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.
摘要翻译: 根据下式(I)的化合物:其中R 1,R 2,R 3和R 4, 如本说明书中所定义,药学上可接受的盐,制备方法,含药物组合物及其使用方法。
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公开(公告)号:US09781064B2
公开(公告)日:2017-10-03
申请号:US14447451
申请日:2014-07-30
申请人: Robert Jacobs , Eric D. Kroll
发明人: Robert Jacobs , Eric D. Kroll
CPC分类号: H04L51/10
摘要: Method and system for creating and distributing professional quality electronic postcards are provided. An accessible library of numerous photographs/videos taken by professionals is maintained, for example, on a app or website. Access to the app or website can be accomplished using any suitable input device, for example smart phones, tablets, laptops, computers etc. Following a series of simple steps, users select from an assortment of images, videos, photos, messages, etc., to create an electronic postcard. Users have their own pages on the app or website, where sent and received electronic postcards are stored. A simple method for creating albums from the user's electronic postcards is also provided.
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公开(公告)号:US20070191422A1
公开(公告)日:2007-08-16
申请号:US10583581
申请日:2004-12-20
申请人: Glen Ernst , Robert Jacobs , Eifion Phillips
发明人: Glen Ernst , Robert Jacobs , Eifion Phillips
IPC分类号: A61K31/4745 , C07D453/02
CPC分类号: C07D453/02
摘要: Compounds of formula (I), wherein D, Ar1, E and Ar2 are as defined in the specification, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, especially in the treatment or prophylaxis of psychotic and intellectual impairment disorders.
摘要翻译: 式(I)化合物,其中D,Ar1,E和Ar2如本说明书中所定义,其制备方法,含有它们的药物组合物及其在治疗中的用途,特别是治疗或预防精神病和智力障碍障碍。
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公开(公告)号:US20070006146A1
公开(公告)日:2007-01-04
申请号:US11165815
申请日:2005-06-24
申请人: Wah Kwong , Prosenjit Ghosh , Katie Mills , Jim Trethewey , Robert Jacobs , Tim Nguyen , Asim Sadiq , Shreekant Thakkar , Murali Veeramoney , Truong Phan
发明人: Wah Kwong , Prosenjit Ghosh , Katie Mills , Jim Trethewey , Robert Jacobs , Tim Nguyen , Asim Sadiq , Shreekant Thakkar , Murali Veeramoney , Truong Phan
IPC分类号: G06F9/44
CPC分类号: G06F1/18
摘要: According to some embodiments, systems and apparatus for enhanced mobile computing platforms are provided. For example, an apparatus or system may comprise a universal computational package, comprising a processor, a memory coupled to the processor, a plurality of instructions stored in the memory directed to at least one specific use of the universal computational package, and a plurality of interface controllers coupled to the processor, wherein each of the plurality of interface controllers is operable to cause the processor to execute the plurality of stored instructions in accordance with the presence of a use-specific user interface cover associated with the at least one specific use of the universal computational package.
摘要翻译: 根据一些实施例,提供了用于增强的移动计算平台的系统和装置。 例如,装置或系统可以包括通用计算包,包括处理器,耦合到处理器的存储器,存储在存储器中的多个指令,用于至少一个特定使用的通用计算包,以及多个 接口控制器,其耦合到所述处理器,其中所述多个接口控制器中的每一个可操作以使得所述处理器根据与所述至少一个特定使用相关联的使用特定用户界面覆盖的存在来执行所述多个存储的指令 通用的计算包。
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公开(公告)号:US5860653A
公开(公告)日:1999-01-19
申请号:US441493
申请日:1995-05-15
申请人: Robert Jacobs
发明人: Robert Jacobs
CPC分类号: G06Q10/107
摘要: Apparatus and method for playing an anagram-type game in a game show or computer game format. One or more anagrams, each comprised of scrambled letters, are displayed on a gameboard. At least one object of the game is to guess the unscrambled solution to each anagram. When correctly guessed, the letters are moved from their scrambled configuration to their unscrambled configuration. An ultimate solution to the puzzle is preferrably revealed by some of the letters of the collective unscrambled anagrams which are moved into a predetermined alignment. Several means are included for making it easier to view, study and follow the progress of the game such as moving each letter along a path, leaving outlines of the letters in their initial positions, and indicating which anagram is to be guessed by a player.
摘要翻译: 用于在游戏节目或计算机游戏格式中播放卦式游戏的装置和方法。 每个包括乱码的一个或多个卦语显示在游戏板上。 游戏的至少一个对象是猜测每个卦语的解扰解。 当被正确猜测时,这些字母从他们的加扰配置移动到他们的未加扰配置。 拼图的最终解决方案最好是通过集合的未加扰的卦语的一些字母来显示,这些字母被移动到预定的对齐位置。 包括了几种手段,使其更容易查看,学习和跟踪游戏的进展,例如沿着路径移动每个字母,将字母的轮廓留在其初始位置,并指示玩家猜测哪个卦语。
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