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公开(公告)号：US20060089346A1
公开(公告)日：2006-04-27
申请号：US10528640
申请日：2003-10-02
申请人： Christopher Becker , Bruce Dembofsky , Robert Jacobs , James Kang , Cyrus Ohnmacht , James Rosamond , Ashokkumar Shenvi , Thomas Simpson , James Woods
发明人： Christopher Becker , Bruce Dembofsky , Robert Jacobs , James Kang , Cyrus Ohnmacht , James Rosamond , Ashokkumar Shenvi , Thomas Simpson , James Woods
IPC分类号： A61K31/554 , A61K31/55 , A61K31/551
CPC分类号： C07K5/06034 , A61K38/00 , C07D223/16 , C07D267/10 , C07D267/14 , C07D281/06 , C07D281/10 , C07D405/04 , C07D417/12 , C07D417/14 , C07K5/06026 , C07K5/06191
摘要： Compounds having the formula (1) pharmaceutical compositions containing them and their methods of use for the treatment of neurological disorders related to amyloid B protein production and neurological disorders such as Alzheimer's disease. These compounds inhibit γ secretase and thereby inhibit the production of amyloid β protein, thereby acting to prevent the formation of neurological deposits of amyloid protein.
摘要翻译： 具有式（1）的药物组合物及其用于治疗与淀粉样蛋白B蛋白质产生和神经障碍如阿尔茨海默病相关的神经障碍的方法。 这些化合物抑制γ分泌酶，从而抑制淀粉样蛋白β蛋白的产生，从而起到防止淀粉样蛋白的神经沉积的形成的作用。
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公开(公告)号：US20080076752A1
公开(公告)日：2008-03-27
申请号：US11844451
申请日：2007-08-24
申请人： Christopher Becker , Bruce Dembofsky , Robert Jacobs , James Kang , Cyrus Ohnmacht , James Rosamond , Ashokkumar Shenvi , Thomas Simpson , James Woods
发明人： Christopher Becker , Bruce Dembofsky , Robert Jacobs , James Kang , Cyrus Ohnmacht , James Rosamond , Ashokkumar Shenvi , Thomas Simpson , James Woods
IPC分类号： A61K31/554 , A61P25/28
CPC分类号： C07K5/06034 , A61K38/00 , C07D223/16 , C07D267/10 , C07D267/14 , C07D281/06 , C07D281/10 , C07D405/04 , C07D417/12 , C07D417/14 , C07K5/06026 , C07K5/06191
摘要： Compounds having the formula (I) pharmaceutical compositions containing them and their methods of use for the treatment of neurological disorders related to amyloid β protein production and neurological disorders such as Alzheimer's disease. These compounds inhibit γ secretase and thereby inhibit the production of amyloid β protein, thereby acting to prevent the formation of neurological deposits of amyloid protein.
摘要翻译： 具有式（I）的药物组合物和含有它们的药物组合物及其用于治疗与淀粉样蛋白β蛋白生产和神经障碍如阿尔茨海默病有关的神经障碍的方法。 这些化合物抑制γ分泌酶，从而抑制淀粉样蛋白β蛋白的产生，从而起到防止淀粉样蛋白的神经沉积的形成的作用。
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公开(公告)号：US07294622B2
公开(公告)日：2007-11-13
申请号：US10528640
申请日：2003-10-02
申请人： Christopher Becker , Bruce Dembofsky , Robert Jacobs , James Kang , Cyrus Ohnmacht , James Rosamond , Ashokkumar Bhikkappa Shenvi , Thomas Simpson , James Woods
发明人： Christopher Becker , Bruce Dembofsky , Robert Jacobs , James Kang , Cyrus Ohnmacht , James Rosamond , Ashokkumar Bhikkappa Shenvi , Thomas Simpson , James Woods
IPC分类号： C07D223/16 , C07D267/14 , C07D281/06 , A61K31/55 , A61P25/28
CPC分类号： C07K5/06034 , A61K38/00 , C07D223/16 , C07D267/10 , C07D267/14 , C07D281/06 , C07D281/10 , C07D405/04 , C07D417/12 , C07D417/14 , C07K5/06026 , C07K5/06191
摘要： Compounds having the formula (I) pharmaceutical compositions containing them and their methods of use for the treatment of neurological disorders related to amyloid β protein production and neurological disorders such as Alzheimer's disease. These compounds inhibit γ secretase and thereby inhibit the production of amyloid β protein, thereby acting to prevent the formation of neurological deposits of amyloid protein.
摘要翻译： 具有式（I）的药物组合物和含有它们的药物组合物及其用于治疗与淀粉样蛋白β蛋白生产和神经障碍如阿尔茨海默病有关的神经障碍的方法。 这些化合物抑制γ分泌酶，从而抑制淀粉样蛋白β蛋白的产生，从而起到防止淀粉样蛋白的神经沉积的形成的作用。
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公开(公告)号：US20090170851A1
公开(公告)日：2009-07-02
申请号：US12403553
申请日：2009-03-13
申请人： Peter Bernstein , Daniel Hill , David Nugiel , Edward Pierson , Ashokkumar Shenvi , Robert Jacobs
发明人： Peter Bernstein , Daniel Hill , David Nugiel , Edward Pierson , Ashokkumar Shenvi , Robert Jacobs
IPC分类号： A61K31/5377 , A61P25/22
CPC分类号： C07D311/66
摘要： Compounds according to Formula (I): wherein R1, R2, R3, and R4 are as defined in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.
摘要翻译： 根据式（I）的化合物：其中R 1，R 2，R 3和R 4如本说明书中所定义，药学上可接受的盐，制备方法，药物组合物及其使用方法。
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公开(公告)号：US20070010526A1
公开(公告)日：2007-01-11
申请号：US10494424
申请日：2002-11-01
申请人： Markus Haeberlein , Christof Angst , Daniel Hill , Robert Jacobs , Gary Moore , Edward Pierson , Ashokkumar Shenvi
发明人： Markus Haeberlein , Christof Angst , Daniel Hill , Robert Jacobs , Gary Moore , Edward Pierson , Ashokkumar Shenvi
IPC分类号： A61K31/496 , A61K31/4709 , C07D403/02 , C07D401/02
CPC分类号： C07D401/04 , C07D217/04 , C07D217/06 , C07D401/12 , C07D405/06 , C07D413/10 , C07D413/12 , C07D417/12
摘要： Provided herein is a compound of the formula (I), wherein said compounds are useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating disorders, dementia, panic disorder, and sleep disorders. The compounds may also be useful in the treatment of gastrointestinal disorders, cardiovascular regulation, motor disorders, endocrine disorders, vasospasm and sexual dysfunction. The compounds are 5HT1B and 5HT1D antagonists.
摘要翻译： 本文提供了式（I）的化合物，其中所述化合物可用于治疗精神障碍，包括但不限于抑郁症，广泛性焦虑症，进食障碍，痴呆症，惊恐障碍和睡眠障碍。 该化合物还可用于治疗胃肠道疾病，心血管调节，运动障碍，内分泌障碍，血管痉挛和性功能障碍。 该化合物是5HT 1B和5HT 1D 1拮抗剂。
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公开(公告)号：US20070185107A1
公开(公告)日：2007-08-09
申请号：US11592686
申请日：2006-11-03
申请人： Peter Bernstein , Daniel Hill , David Nugiel , Edward Pierson , Ashokkumar Shenvi , Robert Jacobs
发明人： Peter Bernstein , Daniel Hill , David Nugiel , Edward Pierson , Ashokkumar Shenvi , Robert Jacobs
IPC分类号： A61K31/5377 , A61K31/497 , C07D413/14 , C07D405/14
CPC分类号： C07D311/66
摘要： Compounds according to Formula (I): wherein R1, R2, R3, and R4 are as defined in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.
摘要翻译： 根据式（I）的化合物：其中R 1，R 2，R 3和R 4均为 如本说明书中所定义的药学上可接受的盐，制备方法，含药物组合物及其使用方法。
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公开(公告)号：US20060183732A1
公开(公告)日：2006-08-17
申请号：US10549271
申请日：2004-03-10
申请人： Keith Herzog , Robert Jacobs , Jianxing Kang , Thomas Simpson , James Woods
发明人： Keith Herzog , Robert Jacobs , Jianxing Kang , Thomas Simpson , James Woods
IPC分类号： A61K31/55 , C07D223/12
CPC分类号： C07D409/12 , C07D223/12 , C07K5/06026 , C07K5/06043 , C07K5/06191
摘要： This invention relates to novel compounds having formula (I) to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit secretase and thereby inhibit the production of amyloid β protein, thereby acting to prevent the formation of neurological deposits of amyloid protein. The present invention relates to the treatment of neurological disorders related to amyloid β-protein production such as Alzheimer's disease.
摘要翻译： 本发明涉及具有式（I）的新化合物及其药物组合物及其使用方法。 这些新型化合物抑制分泌酶，从而抑制淀粉样蛋白β蛋白的产生，从而起到防止淀粉样蛋白神经沉积的形成的作用。 本发明涉及治疗与淀粉样蛋白β-蛋白生产相关的神经障碍，例如阿尔茨海默病。
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公开(公告)号：US07858776B2
公开(公告)日：2010-12-28
申请号：US12359465
申请日：2009-01-26
IPC分类号： C07D223/16
CPC分类号： C07K5/06034 , A61K38/00 , C07D223/16 , C07D267/10 , C07D267/14 , C07D281/06 , C07D281/10 , C07D405/04 , C07D417/12 , C07D417/14 , C07K5/06026 , C07K5/06191
摘要： Compounds having the formula (I) pharmaceutical compositions containing them and their methods of use for the treatment of neurological disorders related to amyloid β protein production and neurological disorders such as Alzheimer's disease. These compounds inhibit γ secretase and thereby inhibit the production of amyloid β protein, thereby acting to prevent the formation of neurological deposits of amyloid protein.
摘要翻译： 具有式（I）的药物组合物含有它们的化合物及其用于治疗与淀粉样蛋白相关的神经障碍的方法; 蛋白质生产和神经系统疾病如阿尔茨海默病。 这些化合物抑制γ分泌酶，从而抑制淀粉样蛋白的生成; 蛋白质，从而起到防止淀粉样蛋白质神经沉积的形成的作用。
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公开(公告)号：US20100160627A1
公开(公告)日：2010-06-24
申请号：US12359465
申请日：2009-01-26
IPC分类号： C07D267/02
CPC分类号： C07K5/06034 , A61K38/00 , C07D223/16 , C07D267/10 , C07D267/14 , C07D281/06 , C07D281/10 , C07D405/04 , C07D417/12 , C07D417/14 , C07K5/06026 , C07K5/06191
摘要： Compounds having the formula (I) pharmaceutical compositions containing them and their methods of use for the treatment of neurological disorders related to amyloid β protein production and neurological disorders such as Alzheimer's disease. These compounds inhibit γ secretase and thereby inhibit the production of amyloid β protein, thereby acting to prevent the formation of neurological deposits of amyloid protein.
摘要翻译： 具有式（I）的药物组合物含有它们的化合物及其用于治疗与淀粉样蛋白相关的神经障碍的方法; 蛋白质生产和神经系统疾病如阿尔茨海默病。 这些化合物抑制γ分泌酶，从而抑制淀粉样蛋白的生成; 蛋白质，从而起到防止淀粉样蛋白质神经沉积的形成的作用。
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公开(公告)号：US09781064B2
公开(公告)日：2017-10-03
申请号：US14447451
申请日：2014-07-30
申请人： Robert Jacobs , Eric D. Kroll
发明人： Robert Jacobs , Eric D. Kroll
CPC分类号： H04L51/10
摘要： Method and system for creating and distributing professional quality electronic postcards are provided. An accessible library of numerous photographs/videos taken by professionals is maintained, for example, on a app or website. Access to the app or website can be accomplished using any suitable input device, for example smart phones, tablets, laptops, computers etc. Following a series of simple steps, users select from an assortment of images, videos, photos, messages, etc., to create an electronic postcard. Users have their own pages on the app or website, where sent and received electronic postcards are stored. A simple method for creating albums from the user's electronic postcards is also provided.
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