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公开(公告)号：US08355767B2
公开(公告)日：2013-01-15
申请号：US11412418
申请日：2006-04-27
申请人： Martin Hunter , Annika Enejder , Thomas Scecina , Michael Feld , Wei-Chuan Shih
发明人： Martin Hunter , Annika Enejder , Thomas Scecina , Michael Feld , Wei-Chuan Shih
IPC分类号： A61B5/1455
CPC分类号： A61B5/14532 , A61B5/1455 , G01N21/65
摘要： The present invention relates to the use of Raman spectroscopy for quantitative, non-invasive transcutaneous measurement of blood analytes, such as glucose. Raman spectroscopy is used to measure glucose transcutaneously, in patients whose blood glucose levels were monitored. Raman spectra were collected transcutaneously along with glucose reference values provided by standard capillary blood analysis. A partial least squares calibration was created from the data from each subject and validated using leave-one-out cross validation.
摘要翻译： 本发明涉及拉曼光谱法用于定量，非侵入性经皮测量血液分析物如葡萄糖的用途。 在监测血糖水平的患者中，拉曼光谱法用于经皮测量葡萄糖。 通过标准毛细管血液分析提供的葡萄糖参考值，经皮收集拉曼光谱。 从每个受试者的数据创建偏最小二乘法校准，并使用离开一对交叉验证进行验证。
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公开(公告)号：US20070060806A1
公开(公告)日：2007-03-15
申请号：US11412418
申请日：2006-04-27
申请人： Martin Hunter , Annika Enejder , Thomas Scecina , Michael Feld , Wei-Chuan Shih
发明人： Martin Hunter , Annika Enejder , Thomas Scecina , Michael Feld , Wei-Chuan Shih
IPC分类号： A61B5/00
CPC分类号： A61B5/14532 , A61B5/1455 , G01N21/65
摘要： The present invention relates to the use of Raman spectroscopy for quantitative, non-invasive transcutaneous measurement of blood analytes, such as glucose. Raman spectroscopy is used to measure glucose transcutaneously, in patients whose blood glucose levels were monitored. Raman spectra were collected transcutaneously along with glucose reference values provided by standard capillary blood analysis. A partial least squares calibration was created from the data from each subject and validated using leave-one-out cross validation.
摘要翻译： 本发明涉及拉曼光谱法用于定量，非侵入性经皮测量血液分析物如葡萄糖的用途。 在监测血糖水平的患者中，拉曼光谱法用于经皮测量葡萄糖。 通过标准毛细管血液分析提供的葡萄糖参考值，经皮收集拉曼光谱。 从每个受试者的数据创建偏最小二乘法校准，并使用离开一对交叉验证进行验证。
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3.发明授权Method for determination of analytes using NIR, adjacent visible spectrum and discrete NIR wavelenths 失效使用NIR，相邻可见光谱和离散NIR波长测定分析物的方法公开(公告)号：US06741876B1
公开(公告)日：2004-05-25
申请号：US10070187
申请日：2002-06-28
IPC分类号： A61B500
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14546
摘要： Described is a method for measuring the concentration of a blood constituent within a body part (80) of a living subject which comprises irradiating a body part of the subject with a continuum of a broad spectrum of radiation in adjacent and near infrared range of the electomagnetic spectrum; collecting the band of radiation after the radiation has been directed onto the part; dispersing the continuum of collected radiation into a dispersed spectrum of component wavelengths onto a detector (120) the detector taking measurements of at least one of transmitted or reflected radiation from the collected radiation; and transferring the measurements to a processor (300), and then measuring the same kind of absorbance or reflectance with respect to one or more a discrete wavelengths of radiation from the longer near infrared range and using the measurements to calculate the concentration of the constituent.
摘要翻译： 描述了一种用于测量活体的身体部分（80）中的血液成分浓度的方法，其包括在电磁场的相邻和近红外范围内以广谱辐射的连续统一照射受试者的身体部位 光谱; 在辐射被引导到部件上之后收集辐射带; 将收集的辐射的连续谱分散到分量波长的分量波长到检测器（120）上，所述检测器从所收集的辐射中测量发射或反射的辐射中的至少一种; 并将测量值传送到处理器（300），然后测量相对于来自较长近红外范围的一个或多个离散波长的吸收或反射率，并使用测量来计算组分的浓度。
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4.发明授权Method for determination of analytes using near infrared, adjacent visible spectrum and an array of longer near infrared wavelengths 失效使用近红外，相邻可见光谱和更长的近红外波长的阵列测定分析物的方法公开(公告)号：US06741875B1
公开(公告)日：2004-05-25
申请号：US10070189
申请日：2002-06-03
IPC分类号： A61B500
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14546 , G01N21/314 , G01N21/359 , G01N2021/3133 , G01N2021/3144 , G01N2021/3148 , G01N2021/3181
摘要： Described is a method which uses spectral data simultaneously collected in a continuous array of discrete wavelength points of the visible spectrum adjacent to the infrared and near infrared part of the light spectrum. The spectral data is collected using a number of detectors with different sensitivity ranges. Some detectors may be sensitive to visible and possibly, to part of the near infrared portion of radiation. Spectral data from die infrared spectrum is collected with the infrared detectors, and are in some embodiments insensitive to the visible links.
摘要翻译： 描述了一种方法，该方法使用同时收集在与光谱的红外线和近红外部分相邻的可见光谱的离散波长点的连续阵列中的频谱数据。 使用具有不同灵敏度范围的多个检测器收集光谱数据。 一些检测器可能对可见光和可能的部分辐射的近红外部分敏感。 用红外探测器收集红外光谱的光谱数据，在一些实施例中对可见链接不敏感。
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5.发明授权Method for creating spectral instrument variation tolerance in calibration algorithms 有权在校准算法中创建光谱仪器变化公差的方法公开(公告)号：US06615151B1
公开(公告)日：2003-09-02
申请号：US09939707
申请日：2001-08-28
IPC分类号： G01N1506
CPC分类号： G01N21/274 , G01N21/359
摘要： The present invention relates to a method of building instrument variation tolerance into calibration algorithms for spectroscopic devices for chemical composition analysis with spectroscopic methods. The method of the present invention is particularly suitable for blood glucose, cholesterol and other chemical components prediction based on near-infrared spectrophotometry measurements. A method includes developing a calibration algorithm on a first instrument; applying the calibration algorithm to a second instrument; calibrating the second instrument and adjusting the calibration algorithm to account for differences between the first instrument and the second instrument; and repeating the step of applying (above) in respect of (n) further instruments to provide a calibration algorithm which may then be used on other instruments. Methods are also provided that develop calibration algorithms by adding instrument variations, based on mathematical manipulation, of the spectral data collected on calibration instruments.
摘要翻译： 本发明涉及一种利用光谱方法对用于化学成分分析的光谱装置的校准算法建立仪器变异公差的方法。 本发明的方法特别适用于基于近红外分光光度法测量的血糖，胆固醇和其他化学成分预测。 一种方法包括在第一仪器上开发校准算法; 将校准算法应用于第二仪器; 校准第二台仪器并调整校准算法以解决第一台仪器与第二台仪器之间的差异; 并重复对（n）个其他仪器应用（上述）的步骤，以提供可以在其他仪器上使用的校准算法。 还提供了通过在校准仪器上收集的光谱数据的基础上添加基于数学操作的仪器变化来开发校准算法的方法。
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