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1.发明授权Method for determination of analytes using NIR, adjacent visible spectrum and discrete NIR wavelenths 失效使用NIR，相邻可见光谱和离散NIR波长测定分析物的方法公开(公告)号：US06741876B1
公开(公告)日：2004-05-25
申请号：US10070187
申请日：2002-06-28
IPC分类号： A61B500
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14546
摘要： Described is a method for measuring the concentration of a blood constituent within a body part (80) of a living subject which comprises irradiating a body part of the subject with a continuum of a broad spectrum of radiation in adjacent and near infrared range of the electomagnetic spectrum; collecting the band of radiation after the radiation has been directed onto the part; dispersing the continuum of collected radiation into a dispersed spectrum of component wavelengths onto a detector (120) the detector taking measurements of at least one of transmitted or reflected radiation from the collected radiation; and transferring the measurements to a processor (300), and then measuring the same kind of absorbance or reflectance with respect to one or more a discrete wavelengths of radiation from the longer near infrared range and using the measurements to calculate the concentration of the constituent.
摘要翻译： 描述了一种用于测量活体的身体部分（80）中的血液成分浓度的方法，其包括在电磁场的相邻和近红外范围内以广谱辐射的连续统一照射受试者的身体部位 光谱; 在辐射被引导到部件上之后收集辐射带; 将收集的辐射的连续谱分散到分量波长的分量波长到检测器（120）上，所述检测器从所收集的辐射中测量发射或反射的辐射中的至少一种; 并将测量值传送到处理器（300），然后测量相对于来自较长近红外范围的一个或多个离散波长的吸收或反射率，并使用测量来计算组分的浓度。
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2.发明授权Method for determination of analytes using near infrared, adjacent visible spectrum and an array of longer near infrared wavelengths 失效使用近红外，相邻可见光谱和更长的近红外波长的阵列测定分析物的方法公开(公告)号：US06741875B1
公开(公告)日：2004-05-25
申请号：US10070189
申请日：2002-06-03
IPC分类号： A61B500
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14546 , G01N21/314 , G01N21/359 , G01N2021/3133 , G01N2021/3144 , G01N2021/3148 , G01N2021/3181
摘要： Described is a method which uses spectral data simultaneously collected in a continuous array of discrete wavelength points of the visible spectrum adjacent to the infrared and near infrared part of the light spectrum. The spectral data is collected using a number of detectors with different sensitivity ranges. Some detectors may be sensitive to visible and possibly, to part of the near infrared portion of radiation. Spectral data from die infrared spectrum is collected with the infrared detectors, and are in some embodiments insensitive to the visible links.
摘要翻译： 描述了一种方法，该方法使用同时收集在与光谱的红外线和近红外部分相邻的可见光谱的离散波长点的连续阵列中的频谱数据。 使用具有不同灵敏度范围的多个检测器收集光谱数据。 一些检测器可能对可见光和可能的部分辐射的近红外部分敏感。 用红外探测器收集红外光谱的光谱数据，在一些实施例中对可见链接不敏感。
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3.发明授权Method for creating spectral instrument variation tolerance in calibration algorithms 有权在校准算法中创建光谱仪器变化公差的方法公开(公告)号：US06615151B1
公开(公告)日：2003-09-02
申请号：US09939707
申请日：2001-08-28
IPC分类号： G01N1506
CPC分类号： G01N21/274 , G01N21/359
摘要： The present invention relates to a method of building instrument variation tolerance into calibration algorithms for spectroscopic devices for chemical composition analysis with spectroscopic methods. The method of the present invention is particularly suitable for blood glucose, cholesterol and other chemical components prediction based on near-infrared spectrophotometry measurements. A method includes developing a calibration algorithm on a first instrument; applying the calibration algorithm to a second instrument; calibrating the second instrument and adjusting the calibration algorithm to account for differences between the first instrument and the second instrument; and repeating the step of applying (above) in respect of (n) further instruments to provide a calibration algorithm which may then be used on other instruments. Methods are also provided that develop calibration algorithms by adding instrument variations, based on mathematical manipulation, of the spectral data collected on calibration instruments.
摘要翻译： 本发明涉及一种利用光谱方法对用于化学成分分析的光谱装置的校准算法建立仪器变异公差的方法。 本发明的方法特别适用于基于近红外分光光度法测量的血糖，胆固醇和其他化学成分预测。 一种方法包括在第一仪器上开发校准算法; 将校准算法应用于第二仪器; 校准第二台仪器并调整校准算法以解决第一台仪器与第二台仪器之间的差异; 并重复对（n）个其他仪器应用（上述）的步骤，以提供可以在其他仪器上使用的校准算法。 还提供了通过在校准仪器上收集的光谱数据的基础上添加基于数学操作的仪器变化来开发校准算法的方法。
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公开(公告)号：US06919566B1
公开(公告)日：2005-07-19
申请号：US10049699
申请日：2000-08-31
申请人： Theodore E. Cadell
发明人： Theodore E. Cadell
CPC分类号： G01N21/359 , A61B5/14532 , A61B5/1495 , G01N21/274 , G01N21/314 , G01N2201/129
摘要： The present invention provides a method of calibrating a spectroscopic device for providing a non-invasive measurement of an analyte level in a sample. The method comprises the steps of: (a) providing a plurality of calibration algorithms; (b) taking a set of non-invasive measurements on said sample with said spectroscopic device; (c) calculating a predicted set of analyte levels for each of the calibration algorithms in response to the set of non-invasive measurements, each of the predicted sets of analyte levels being characterized by a variability range, a slope, an R2 (a square of the correlation between said set of non-invasive measurements and said predicted set of analyte levels), and a standard error of prediction; and (d) selecting an appropriate calibration algorithm by using a suitability score based on the variability range, the slope, the R2 an the standard error of prediction for each of the predicted sets of analyte levels. A method of generating suitable calibration algorithms in step (a) is also provided.
摘要翻译： 本发明提供了一种校准分光装置的方法，用于提供样品中分析物水平的非侵入性测量。 该方法包括以下步骤：（a）提供多个校准算法; （b）用所述分光装置对所述样品进行一组非侵入性测量; （c）响应于所述一组非侵入性测量，计算每个所述校准算法的分析物水平的预测集合，所述预测分析物水平集合的每一个的特征在于可变性范围，斜率， <？img id =“CUSTOM-CHARACTER-00001”he =“2.46mm”wi =“1.78mm”file =“US06919566-20050719-P00900.TIF”alt =“custom character”img-content =“character”img- 格式=“tif”？> 2 <？img id =“CUSTOM-CHARACTER-00002”he =“2.46mm”wi =“1.78mm”file =“US06919566-20050719-P00900.TIF” alt =“自定义字符”img-content =“character”img-format =“tif”？> （所述非侵入性测量集合与所述预测分析物水平集之间的相关性的平方），以及 预测的标准误差 以及（d）通过使用基于可变性范围，斜率，R 2的适合性评分来选择适当的校准算法，对于每个预测的分析物水平集合的预测的标准误差。 还提供了在步骤（a）中产生合适的校准算法的方法。
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公开(公告)号：US5429128A
公开(公告)日：1995-07-04
申请号：US43464
申请日：1993-02-24
IPC分类号： A61B5/145 , A61B5/00 , A61B5/1455
CPC分类号： A61B5/6843 , A61B5/14552
摘要： A finger receptor is used with a non-invasive monitoring device to determine non-invasively the concentration of known constituents in blood or tissue. The receptor has a channel for receiving a finger of a user. The channel has a light entrance and a light exit so that light can be passed from a light source through a finger located in the channel in a direction generally normal to the finger. Extraneous light is excluded and the finger is held in position by a spring-mounted roller. The receptor has sensing means to determine when a finger has been properly positioned in the channel. Previous devices are not capable of achieving repeatable results to a sufficient degree to replace invasive methods of testing.
摘要翻译： 手指受体与非侵入性监测装置一起使用以非侵入性地确定血液或组织中已知成分的浓度。 受体具有用于接收用户手指的通道。 通道具有光入射和光出射，使得光可以从光源通过位于通道中的手指沿着通常垂直于手指的方向通过。 外部光被排除，手指通过弹簧安装的滚轮固定在位。 受体具有感测装置，用于确定手指何时在通道中正确定位。 以前的设备不能够在足够的程度上实现可重复的结果来代替侵入性测试方法。
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6.发明授权Apparatus and method for rapid spectrophotometric pre-test screen of specimen for a blood analyzer 有权用于血液分析仪的样品快速分光光度测试前屏幕的装置和方法公开(公告)号：US06195158B1
公开(公告)日：2001-02-27
申请号：US09068835
申请日：1999-02-08
IPC分类号： G01N2127
CPC分类号： G01N21/3103 , G01N15/05 , G01N21/274
摘要： A method and apparatus for use in respect of samples which are assessed for quality prior to testing in a clinical analyzer. The method and apparatus identify parameters such as gel level and height of fluid above the gel in blood samples, where appropriate, for the purposes of positioning the specimen for determination of interferents. Such interferents include hemoglobin (Hb), total bilirubin and lipids. These interferents are determined by measurement of absorption of different wavelengths of light in serum or plasma, or other specimens, which are then compared with values obtained through calibration using reference measurements for the respective interferents in serum or plasma or other type of specimen. Determinations of temperature of the specimen, as well as specimen type, for example whether the specimen is urine or plasma or serum, may also be carried out.
摘要翻译： 用于在临床分析仪中测试之前评估质量的样品的方法和装置。 该方法和装置在适当的情况下鉴定凝血水平和血液样品上方凝胶高度的参数，以便定位样品以确定干扰物。 这种干扰物包括血红蛋白（Hb），总胆红素和脂质。 这些干扰物通过测量血清或血浆或其他样品中不同波长的光的吸收来确定，然后将其与使用血清或血浆或其他类型样品中各自干扰物的参考测量通过校准获得的值进行比较。 也可以测定样品的温度以及样品类型，例如样品是尿液还是血浆或血清。
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公开(公告)号：US06657717B2
公开(公告)日：2003-12-02
申请号：US10085983
申请日：2002-02-28
申请人： Theodore E. Cadell , Paul Drennan , James Samsoondar , Romuald Pawluczyk , Ashwani Kaushal , Bronislaw Bednarz , John Kuta
发明人： Theodore E. Cadell , Paul Drennan , James Samsoondar , Romuald Pawluczyk , Ashwani Kaushal , Bronislaw Bednarz , John Kuta
IPC分类号： G01J410
CPC分类号： B82Y15/00 , A61B5/14532 , A61B5/1455 , A61B5/1495 , A61B2560/0233 , G01N21/4785 , Y10S977/904 , Y10S977/926 , Y10S977/954 , Y10S977/958
摘要： The present invention provides an artificial member (80, 210) which mimics the absorbance spectrum of a body part and includes the spectral components of blood analytes. The artificial member comprises a light scattering and reflecting material, and has a chamber portion comprising one or more chambers (90, 100, 220). The artificial member is configured to be reproducibly received in a measuring receptor which receptor is operatively connected to a non-invasive monitoring device.
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公开(公告)号：US06522398B2
公开(公告)日：2003-02-18
申请号：US09732211
申请日：2000-12-08
IPC分类号： G01N2147
CPC分类号： G01N21/3103
摘要： A method and apparatus for use in respect of samples which are assessed for quality prior to testing in a clinical analyzer. The method and apparatus identify parameters such as gel level and height of fluid above the gel in blood samples, where appropriate, for the purposes of positioning the specimen for determination of interferents. Such interferents include hemoglobin (Hb), total bilirubin and lipids. These interferents are determined by measurement of absorption of different wavelengths of light in serum or plasma, or other speciments, which are then compared with values obtained through calibration using reference measurements for the respective interferents in serum or plasma or other type of specimen. Determination of temperature of the specimen, as well as specimen type, for example whether the specimen is urine or plasma or serum, may also be carried out.
摘要翻译： 用于在临床分析仪中测试之前评估质量的样品的方法和装置。 该方法和装置在适当的情况下鉴定凝血水平和血液样品上方凝胶高度的参数，以便定位样品以确定干扰物。 这种干扰物包括血红蛋白（Hb），总胆红素和脂质。 这些干扰物是通过测量血清或血浆或其他样品中不同波长的光的吸收来测定的，然后将其与通过使用血清或血浆或其它类型样品中各个干扰物的参考测量的校准获得的值进行比较。 样品的温度以及样品类型的测定，例如样品是否为尿液或血浆或血清，也可以进行。
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公开(公告)号：US4958645A
公开(公告)日：1990-09-25
申请号：US271637
申请日：1988-11-16
申请人： Theodore E. Cadell , Kevin Rabalais
发明人： Theodore E. Cadell , Kevin Rabalais
CPC分类号： A61B5/1113 , A61B5/0017 , A61B5/002 , G07C9/00111 , G06F19/3418
摘要： A medical radio telemetry system has a plurality of telemeters with one telemeter being located on each patient. Each telemeter is connected to the patient to collect data such as temperature, heart rate, pacer rate, respiration rate, brain activity level and blood pressure level. Each telemeter has a patient locator system that functions in conjunction with one or more room locator transmitters. The room locator transmitters are spaced in the rooms or area where the location of a patient is being monitored. A signal from the patient locator transmitter is passed to the patient telemeter. All signals received by the patient telemeter are transmitted to an antenna system that is connected to a receiver. Preferably, there is more than one antenna system with means for switching between the systems to obtain the best signal. Each telemeter has up to six channels so that six separate signals can be sent to the receiver simultaneously. The receiver is connected to a display means for the signals.
摘要翻译： 医疗无线电遥测系统具有多个遥测仪，每个患者具有一个遥测仪。 每个遥测仪连接到患者以收集温度，心率，起搏率，呼吸速率，脑活动水平和血压水平等数据。 每个遥测仪具有与一个或多个房间定位器发射器一起工作的患者定位器系统。 房间定位器发射器在房间或病人位置被监视的区域间隔开。 来自患者定位器发射器的信号被传递到患者远程计。 由患者电表接收的所有信号被发送到连接到接收器的天线系统。 优选地，存在多于一个天线系统，其具有用于在系统之间切换以获得最佳信号的装置。 每个遥测仪最多可以有六个通道，以便可以将六个独立的信号同时发送到接收器。 接收器连接到用于信号的显示装置。
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