公开(公告)号：US20070041945A1

公开(公告)日：2007-02-22

申请号：US11537566

申请日：2006-09-29

申请人： Martin JENSEN ,  Peter Rasmussen ,  Klaus Nielsen

发明人： Martin JENSEN ,  Peter Rasmussen ,  Klaus Nielsen

IPC分类号： A61K48/00 ,  A61K39/395 ,  C07K16/18 ,  C12N1/20 ,  C12N1/18 ,  C12P21/08 ,  C12N15/86 ,  C12N5/06

CPC分类号： G01N33/6896 ,  A61K38/00 ,  A61K38/1709 ,  A61K38/19 ,  A61K39/00 ,  A61K39/0007 ,  A61K39/385 ,  A61K47/646 ,  A61K2039/53 ,  A61K2039/6037 ,  A61K2039/6087 ,  A61K2039/64 ,  C07K14/4711 ,  C07K2319/00 ,  G01N2333/4709 ,  G01N2500/04 ,  Y02A50/412 ,  A61K2300/00

摘要： A method for in vivo down-regulation of amyloid protein in an animal, including a human being, the method comprising effecting presentation to the animal's immune system of an immunogenically effective amount of at least one amyloidogenic polypeptide or subsequence thereof which has been formulated so that immunization of the animal with the amyloidgenic polypeptide or subsequence thereof induces production of antibodies against the amyloidogenic polypeptide, and/or at least one analogue of the amyloidogenic polypeptide wherein is introduced at least one modification in the amino acid sequence of the amyloidogenic polypeptide which has as a result the immunization of the animal with the analogue induces production of antibodies against the amyloidogenic polypeptide.

摘要翻译： 一种用于动物体内下调淀粉样蛋白的方法，包括人，所述方法包括向动物的免疫系统呈递免疫有效量的至少一种淀粉样变性多肽或其子序列，其被配制成使得 用淀粉样蛋白生成多肽或其子序列免疫动物诱导针对淀粉样变性多肽和/或淀粉样变性多肽的至少一种类似物的抗体的产生，其中引入淀粉样变性多肽的氨基酸序列中的至少一个修饰，其具有如 结果，用该类似物的动物的免疫诱导产生针对淀粉样变性多肽的抗体。