公开(公告)号：US08148369B2

公开(公告)日：2012-04-03

申请号：US12151585

申请日：2008-05-07

申请人： Martin James Inglis Andrews ,  Mark Stuart Chambers ,  Wolfgang Schmidt ,  Giovanni Alessandro Tricarico ,  Grégory Louis Joseph Bar ,  Kim Louise Hirst ,  Olga Raquel Pinto Santos Oliveira Roussel ,  Juha Andrew Clase

发明人： Martin James Inglis Andrews ,  Mark Stuart Chambers ,  Wolfgang Schmidt ,  Giovanni Alessandro Tricarico ,  Grégory Louis Joseph Bar ,  Kim Louise Hirst ,  Olga Raquel Pinto Santos Oliveira Roussel ,  Juha Andrew Clase

IPC分类号： A61K31/50 ,  A61K31/535 ,  C07D413/14 ,  C07D471/04

CPC分类号： C07D487/04

摘要： Novel fused pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammation, rheumatoid arthritis and others.

公开(公告)号：US09006237B2

公开(公告)日：2015-04-14

申请号：US13411450

申请日：2012-03-02

申请人： Martin James Inglis Andrews ,  Mark Stuart Chambers ,  Wolfgang Schmidt ,  Giovanni Alessandro Tricarico ,  Grégory Louis Joseph Bar ,  Kim Louise Hirst ,  Olga Raquel Pinto Santos Oliveira Roussel ,  Juha Andrew Clase

发明人： Martin James Inglis Andrews ,  Mark Stuart Chambers ,  Wolfgang Schmidt ,  Giovanni Alessandro Tricarico ,  Grégory Louis Joseph Bar ,  Kim Louise Hirst ,  Olga Raquel Pinto Santos Oliveira Roussel ,  Juha Andrew Clase

IPC分类号： A61K31/503 ,  A61K31/4985 ,  C07D403/12 ,  C07D407/04 ,  C07D487/04

CPC分类号： C07D487/04

摘要： Novel fused pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammation, rheumatoid arthritis and others.

公开(公告)号：US20120232075A1

公开(公告)日：2012-09-13

申请号：US13411450

申请日：2012-03-02

申请人： Martin James Inglis Andrews ,  Mark Stuart Chambers ,  Wolfgang Schmidt ,  Giovanni Alessandro Tricarico ,  Grégory Louis Joseph Bar ,  Kim Louise Hirst ,  Olga Raquel Pinto Santos Oliveira Roussel ,  Juha Andrew Clase

发明人： Martin James Inglis Andrews ,  Mark Stuart Chambers ,  Wolfgang Schmidt ,  Giovanni Alessandro Tricarico ,  Grégory Louis Joseph Bar ,  Kim Louise Hirst ,  Olga Raquel Pinto Santos Oliveira Roussel ,  Juha Andrew Clase

IPC分类号： A61K31/4985 ,  A61K31/5377 ,  A61P29/00 ,  A61P19/02 ,  A61P19/10 ,  A61P19/04 ,  A61P1/02 ,  A61P35/04 ,  A61P11/00 ,  A61P11/06 ,  A61P13/12 ,  A61P1/16 ,  A61P9/10 ,  A61P9/04 ,  A61P25/00 ,  C07D487/04

CPC分类号： C07D487/04

摘要： Novel fused pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammation, rheumatoid arthritis and others.

摘要翻译： 公开了具有下列表示的式的新型稠合吡嗪化合物：该化合物可以制备成药物组合物，并且可用于预防和治疗包括人在内的哺乳动物中的各种病症，包括以非限制性方式 例如炎症，类风湿关节炎等。

公开(公告)号：US08138193B2

公开(公告)日：2012-03-20

申请号：US12753383

申请日：2010-04-02

申请人： Martin James Inglis Andrews ,  Mark Stuart Chambers ,  Wolfgang Schmidt ,  Grégory Louis Joseph Bar

发明人： Martin James Inglis Andrews ,  Mark Stuart Chambers ,  Wolfgang Schmidt ,  Grégory Louis Joseph Bar

IPC分类号： A61K31/4965

CPC分类号： C07D487/04

摘要： Novel fused pyrazine compounds are disclosed that have a formula represented by the following: with Z, R1, R2, R8 and R9 as defined in the written description. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammation, rheumatoid arthritis and others.

摘要翻译： 公开了具有由以下表示的式的新型稠合吡嗪化合物：如书面描述中所定义的Z，R 1，R 2，R 8和R 9。 化合物可以制备成药物组合物，并且可以用于预防和治疗包括人在内的哺乳动物中的多种病症，包括作为非限制性实例，炎症，类风湿性关节炎等。

公开(公告)号：US08133895B2

公开(公告)日：2012-03-13

申请号：US12151586

申请日：2008-05-07

申请人： Martin James Inglis Andrews ,  Mark Stuart Chambers ,  Wolfgang Schmidt ,  Grégory Louis Joseph Bar

发明人： Martin James Inglis Andrews ,  Mark Stuart Chambers ,  Wolfgang Schmidt ,  Grégory Louis Joseph Bar

IPC分类号： A61K31/4965

CPC分类号： C07D487/04

摘要： Novel fused pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammation, rheumatoid arthritis and others.

摘要翻译： 公开了具有下列表示的式的新型稠合吡嗪化合物：该化合物可以制备成药物组合物，并且可用于预防和治疗包括人在内的哺乳动物中的各种病症，包括以非限制性方式 例如，炎症，类风湿关节炎等。

公开(公告)号：US20100240666A1

公开(公告)日：2010-09-23

申请号：US12753383

申请日：2010-04-02

申请人： Martin James Inglis ANDREWS ,  Mark Stuart Chambers ,  Wolfgang Schmidt ,  Grégory Louis Joseph Bar

发明人： Martin James Inglis ANDREWS ,  Mark Stuart Chambers ,  Wolfgang Schmidt ,  Grégory Louis Joseph Bar

IPC分类号： A61K31/4985 ,  C07D471/04 ,  A61P19/02

CPC分类号： C07D487/04

摘要： Novel fused pyrazine compounds are disclosed that have a formula represented by the following: with Z, R1, R2, R8 and R9 as defined in the written description. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammation, rheumatoid arthritis and others.

摘要翻译： 公开了具有由以下表示的式的新型稠合吡嗪化合物：如书面描述中所定义的Z，R 1，R 2，R 8和R 9。 化合物可以制备成药物组合物，并且可以用于预防和治疗包括人在内的哺乳动物中的多种病症，包括作为非限制性实例，炎症，类风湿性关节炎等。

公开(公告)号：US20090286798A1

公开(公告)日：2009-11-19

申请号：US12436219

申请日：2009-05-06

申请人： Martin James Inglis Andrews ,  Mark Stuart Chambers ,  Hervé Van De Poël ,  Grégory Louis Joseph Bar

发明人： Martin James Inglis Andrews ,  Mark Stuart Chambers ,  Hervé Van De Poël ,  Grégory Louis Joseph Bar

IPC分类号： A61K31/4985 ,  C07D487/04 ,  A61P29/00

CPC分类号： C07D519/00

摘要： Novel[1.2.4]triazolo[1,5-a]pyrazine and imidazo[1,2-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, and others.

摘要翻译： 公开了具有下列化学式的新型[1.2.4]三唑并[1,5-a]吡嗪和咪唑并[1,2-a]吡嗪化合物：该化合物可以制备为药物组合物，并且可以使用 用于预防和治疗包括人在内的哺乳动物中的各种病症，包括作为非限制性实例，疼痛，炎症等。

公开(公告)号：US08012983B2

公开(公告)日：2011-09-06

申请号：US12436219

申请日：2009-05-06

申请人： Martin James Inglis Andrews ,  Mark Stuart Chambers ,  Hervé Van De Poël ,  Grégory Louis Joseph Bar

发明人： Martin James Inglis Andrews ,  Mark Stuart Chambers ,  Hervé Van De Poël ,  Grégory Louis Joseph Bar

IPC分类号： A61K31/4965

CPC分类号： C07D519/00

摘要： Novel [1.2.4]triazolo[1,5-a]pyrazine and imidazo[1,2-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, and others.

摘要翻译： 公开了具有下列化学式的新型[1.2.4]三唑并[1,5-a]吡嗪和咪唑并[1,2-a]吡嗪化合物：该化合物可以制备为药物组合物，并且可以使用 用于预防和治疗包括人在内的哺乳动物中的各种病症，包括作为非限制性实例，疼痛，炎症等。

公开(公告)号：US07951818B2

公开(公告)日：2011-05-31

申请号：US11998818

申请日：2007-11-30

申请人： Paul John Edwards ,  Sébastien Laurent Xavier Martina ,  Martin James Inglis Andrews ,  Grégory Louis Joseph Bar ,  Brigitte Allart ,  Andrew Burritt ,  Xueliang Tao ,  Friedrich Erich Karl Kroll

发明人： Paul John Edwards ,  Sébastien Laurent Xavier Martina ,  Martin James Inglis Andrews ,  Grégory Louis Joseph Bar ,  Brigitte Allart ,  Andrew Burritt ,  Xueliang Tao ,  Friedrich Erich Karl Kroll

IPC分类号： A61K31/44

CPC分类号： C07D471/04

摘要： Novel imidazolopyridine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, ECM degradation, joint degradation and/or inflammation, and others.

摘要翻译： 公开了具有下列化学式的新型咪唑并吡啶化合物：该化合物可以制备成药物组合物，并可用于预防和治疗包括人在内的哺乳动物中的多种病症，包括作为非限制性实例 ，ECM降解，关节降解和/或炎症等。