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公开(公告)号:US20050064396A1
公开(公告)日:2005-03-24
申请号:US10916647
申请日:2004-08-10
申请人: Martin Kruger , Peter Welch , Jack Barber
发明人: Martin Kruger , Peter Welch , Jack Barber
CPC分类号: C12N15/113 , A61K38/00 , C07K14/4705 , C12N2310/111 , C12N2799/027 , G01N2333/18 , G01N2500/04
摘要: A method of identifying a compound that modulates the activity of a cellular regulator is provided. The method consists of contacting a sample containing a cellular regulator and a nucleic acid element acted on by the cellular regulator with a test compound under conditions that allow replication or expression of the nucleic acid element or a gene or MRNA operatively linked to the nucleic acid element or gene, and an increase or decrease in the amount of replication or expression in the presence of the test compound compared to the absence of the test compound indicates that the compound has cellular regulator modulatory activity. A method of treating a HCV infection is also provided.
摘要翻译: 提供了鉴定调节细胞调节剂活性的化合物的方法。 该方法包括在允许复制或表达核酸元件或可操作地连接到核酸元件的基因或MRNA的条件下将包含细胞调节剂的样品和由细胞调节剂作用的核酸元件与测试化合物接触 或基因,并且与不存在测试化合物相比,在测试化合物存在下复制或表达量的增加或减少表示该化合物具有细胞调节调节活性。 还提供了治疗HCV感染的方法。
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公开(公告)号:USD281650S
公开(公告)日:1985-12-10
申请号:US527994
申请日:1983-08-31
申请人: Harvey Bomes , John Pulichino , Jack Barber , Max Bell
设计人: Harvey Bomes , John Pulichino , Jack Barber , Max Bell
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公开(公告)号:USD281647S
公开(公告)日:1985-12-10
申请号:US524205
申请日:1983-08-18
申请人: Harvey Bomes , John Pulichino , John Migliore , Jack Barber
设计人: Harvey Bomes , John Pulichino , John Migliore , Jack Barber
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公开(公告)号:USD281646S
公开(公告)日:1985-12-10
申请号:US524160
申请日:1983-08-18
申请人: Harvey Bomes , John Pulichino , John Migliore , Jack Barber
设计人: Harvey Bomes , John Pulichino , John Migliore , Jack Barber
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公开(公告)号:USD282506S
公开(公告)日:1986-02-11
申请号:US524209
申请日:1983-08-18
申请人: Harvey Bomes , John Pulichino , John Migliore , Jack Barber
设计人: Harvey Bomes , John Pulichino , John Migliore , Jack Barber
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公开(公告)号:USD282505S
公开(公告)日:1986-02-11
申请号:US528176
申请日:1983-08-31
申请人: Harvey Bomes , John Pulichino , Jack Barber , John Migliore
设计人: Harvey Bomes , John Pulichino , Jack Barber , John Migliore
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公开(公告)号:USD281651S
公开(公告)日:1985-12-10
申请号:US527995
申请日:1983-08-31
申请人: Harvey Bomes , John Pulichino , Jack Barber , John Migliore
设计人: Harvey Bomes , John Pulichino , Jack Barber , John Migliore
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公开(公告)号:USD281649S
公开(公告)日:1985-12-10
申请号:US524207
申请日:1983-08-18
申请人: Harvey Bomes , John Pulichino , John Migliore , Jack Barber
设计人: Harvey Bomes , John Pulichino , John Migliore , Jack Barber
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公开(公告)号:USD277618S
公开(公告)日:1985-02-19
申请号:US458952
申请日:1983-01-18
申请人: Harvey J. Bomes , John J. Migliore , John Pulichino , Jack Barber
设计人: Harvey J. Bomes , John J. Migliore , John Pulichino , Jack Barber
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10.Methods and compositions for inhibiting HIV infection of cells by cleaving HIV co-receptor RNA 失效
标题翻译: 通过切割HIV辅助受体RNA来抑制细胞的HIV感染的方法和组合物公开(公告)号:US5939538A
公开(公告)日:1999-08-17
申请号:US770235
申请日:1996-12-19
申请人: Markley C. Leavitt , Richard Tritz , Yu Feng , Jack Barber , Mang Yu
发明人: Markley C. Leavitt , Richard Tritz , Yu Feng , Jack Barber , Mang Yu
IPC分类号: A61K38/00 , A61K48/00 , C12N15/113 , C07H21/02
CPC分类号: C12N15/1137 , A61K38/00 , A61K48/00 , C12N2310/111 , C12N2799/025
摘要: Methods of inhibiting HIV infection by blocking HIV co-receptor RNA expression are provided. Ribozymes which cleave HIV co-receptor RNA and inhibit HIV infection of cells are also provided. Co-receptor targets include fusin and CKR5.
摘要翻译: 提供了通过阻断HIV共受体RNA表达来抑制HIV感染的方法。 还提供了切割HIV辅助受体RNA并抑制细胞的HIV感染的核酶。 辅助受体目标包括fusin和CKR5。
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