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公开(公告)号:US20100310552A1
公开(公告)日:2010-12-09
申请号:US12799282
申请日:2010-04-21
IPC分类号: C12N15/877 , C12P21/00 , C07K16/02 , A61K39/395
CPC分类号: C07K16/00 , A01K67/0275 , A01K2207/15 , A01K2217/052 , A01K2217/206 , A01K2227/30 , A01K2267/01 , C07K14/505 , C07K14/535 , C07K14/56 , C07K14/8135 , C07K2317/11 , C07K2317/23 , C07K2317/92 , C12N9/2462 , C12N9/86 , C12N15/85 , C12N15/8509 , C12N15/87 , C12N2799/027 , C12N2830/15 , C12N2830/90 , C12N2840/203
摘要: The invention relates to transgenic avians which produce antibodies in the egg white by introducing a nucleic acid sequence into the genome of an avian embryo wherein the nucleic acid sequence comprises a nucleotide sequence encoding an antibody and to the antibodies and to methods related thereto.
摘要翻译: 本发明涉及通过将核酸序列引入禽胚胎的基因组中而产生蛋清中的抗体的转基因鸟类,其中所述核酸序列包含编码抗体的核苷酸序列和与抗体相关的方法。
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公开(公告)号:US20090210951A1
公开(公告)日:2009-08-20
申请号:US12386223
申请日:2009-04-15
申请人: Robert Ivarie , Arthur Karnuah , Markley C. Leavitt , Jeff Rapp
发明人: Robert Ivarie , Arthur Karnuah , Markley C. Leavitt , Jeff Rapp
CPC分类号: C12N15/8509 , A01K67/0278 , A01K2217/05 , A01K2217/072 , A01K2227/30 , A01K2267/01 , C07K16/00 , C07K2317/11 , C07K2317/21 , C12N2799/02 , C12N2800/10 , C12N2800/204 , C12N2800/206 , C12N2830/90
摘要: The invention includes delivering to an avian a nucleic acid molecule which includes nucleotide sequence of an ovalbumin gene expression controlling region and a heterologous coding sequence operably linked to the gene expression controlling region wherein the heterologous coding sequence is expressed in a cell of the avian.
摘要翻译: 本发明包括递送给禽类核酸分子,其包括卵白蛋白基因表达控制区的核苷酸序列和与基因表达控制区可操作地连接的异源编码序列,其中异源编码序列在禽的细胞中表达。
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公开(公告)号:US07507873B2
公开(公告)日:2009-03-24
申请号:US11649543
申请日:2007-01-04
IPC分类号: A01K67/027 , A01K67/00 , A01K67/033
CPC分类号: C07K16/02 , A01K67/0275 , A01K2217/05 , A01K2227/30 , A01K2267/01 , C07K16/2809 , C07K16/44 , C07K2317/21 , C07K2317/732 , C07K2317/734 , C07K2319/30 , C12N15/8509 , C12N2800/204 , C12N2800/30 , C12N2830/008
摘要: Transgenic avians having a recombinant ovomucoid gene expression controlling region operably linked to one or more useful amino acid coding sequences.
摘要翻译: 具有与一个或多个有用的氨基酸编码序列可操作地连接的重组卵巢粘蛋白基因表达控制区的转基因鸟类。
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公开(公告)号:US07812215B2
公开(公告)日:2010-10-12
申请号:US12313064
申请日:2008-11-17
IPC分类号: C12P21/00 , A01K67/027
CPC分类号: C07K16/02 , A01K67/0275 , A01K2217/05 , A01K2227/30 , A01K2267/01 , C07K16/2809 , C07K16/44 , C07K2317/21 , C07K2317/732 , C07K2317/734 , C07K2319/30 , C12N15/8509 , C12N2800/204 , C12N2800/30 , C12N2830/008
摘要: Methods of producing protein using a recombinant ovomucoid gene expression controlling region operably linked to one or more useful amino acid coding sequences.
摘要翻译: 使用与一个或多个有用的氨基酸编码序列有效连接的重组卵巢粘蛋白基因表达控制区产生蛋白质的方法。
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公开(公告)号:US07795496B2
公开(公告)日:2010-09-14
申请号:US12378304
申请日:2009-02-13
IPC分类号: C12N15/00 , A01K67/027
CPC分类号: C12N15/87 , A01K67/0275 , A01K2217/05 , A01K2227/30 , A01K2267/02 , C12N15/8509 , C12N2800/30
摘要: The present invention provides for methods of producing transgenic avians which may include delivering a heterologous nucleic acid to oviduct tissue of an avian wherein the nucleic acid enters a cell of the oviduct tissue and is expressed.
摘要翻译: 本发明提供了生产转基因鸟类的方法,其可以包括将异源核酸递送到禽类的输卵管组织,其中核酸进入输卵管组织的细胞并被表达。
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公开(公告)号:US20090193534A1
公开(公告)日:2009-07-30
申请号:US12378304
申请日:2009-02-13
IPC分类号: C12N15/12 , A61K31/711
CPC分类号: C12N15/87 , A01K67/0275 , A01K2217/05 , A01K2227/30 , A01K2267/02 , C12N15/8509 , C12N2800/30
摘要: The present invention provides for methods of producing transgenic avians which may include delivering a heterologous nucleic acid to oviduct tissue of an avian wherein the nucleic acid enters a cell of the oviduct tissue and is expressed.
摘要翻译: 本发明提供了生产转基因鸟类的方法,其可以包括将异源核酸递送到禽类的输卵管组织,其中核酸进入输卵管组织的细胞并被表达。
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公开(公告)号:US20090188002A1
公开(公告)日:2009-07-23
申请号:US12316591
申请日:2008-12-12
IPC分类号: A01K67/027 , C12N15/85
CPC分类号: C12N9/22 , A01K67/0275 , A01K2217/05 , A01K2227/30 , A01K2227/40 , A01K2267/01 , C12N15/8509 , C12N15/873 , C12N2800/20 , C12N2800/204 , C12N2800/206 , C12N2830/00 , C12N2830/40 , C12N2830/90 , C12N2840/203
摘要: The invention includes avians containing an artificial chromosome in their genome and methods of making the avians.
摘要翻译: 本发明包括在其基因组中含有人造染色体的鸟类和制作鸟类的方法。
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公开(公告)号:US07335761B2
公开(公告)日:2008-02-26
申请号:US11047184
申请日:2005-01-31
CPC分类号: C07K16/02 , A01K67/0275 , A01K2217/05 , A01K2227/30 , A01K2267/01 , C07K16/2809 , C07K16/44 , C07K2317/21 , C07K2317/732 , C07K2317/734 , C07K2319/30 , C12N15/8509 , C12N2800/204 , C12N2800/30 , C12N2830/008
摘要: The present invention includes avian ovomucoid gene expression controlling regions which may be operably linked to one or more useful amino acid coding sequences.
摘要翻译: 本发明包括可以与一个或多个有用的氨基酸编码序列可操作地连接的鸟类卵类粘蛋白基因表达控制区。
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公开(公告)号:US07585963B2
公开(公告)日:2009-09-08
申请号:US10733042
申请日:2003-12-11
申请人: Markley C. Leavitt , Jeff Rapp , Robert Ivarie , Arthur Karnuah
发明人: Markley C. Leavitt , Jeff Rapp , Robert Ivarie , Arthur Karnuah
CPC分类号: C12N15/8509 , A01K67/0278 , A01K2217/05 , A01K2217/072 , A01K2227/30 , A01K2267/01 , C07K16/00 , C07K2317/11 , C07K2317/21 , C12N2799/02 , C12N2800/10 , C12N2800/204 , C12N2800/206 , C12N2830/90
摘要: The present invention provides isolated and recombinant avian nucleic acid molecules comprising at least one avian MAR and an avian nucleic acid sequence encoding an ovalbumin transcriptional regulatory region. The isolated nucleic acid of the present invention is useful for reducing chromosomal positional effects upon the transcription of a transgene operably linked to the ovalbumin transcriptional regulatory region and transfected into a recipient avian cell The recombinant nucleic acid molecules of the present invention may further comprise a polyadenylation signal sequence or an avian 3′ domain, and optionally, an internal ribosome entry site for expression of an operably linked heterologous nucleic acid insert in a transfected avian cell.
摘要翻译: 本发明提供分离和重组的禽类核酸分子,其包含至少一种禽类MAR和编码卵白蛋白转录调节区的禽类核酸序列。 本发明的分离的核酸可用于降低可操作地连接到卵白蛋白转录调节区并转染到接受者禽类细胞中的转基因的转录上的染色体位置效应。本发明的重组核酸分子还可以包含聚腺苷酸化 信号序列或鸟类3'结构域,以及任选的内部核糖体进入位点,用于在转染的禽类细胞中表达可操作地连接的异源核酸插入物。
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公开(公告)号:US07381712B2
公开(公告)日:2008-06-03
申请号:US10842606
申请日:2004-05-10
IPC分类号: A01N43/04 , C12P21/00 , A01K67/027 , C12N15/00
CPC分类号: A01K67/0275 , A01K2217/05 , A01K2227/30 , A01K2267/02 , C12N15/8509 , C12N15/87 , C12N2800/30
摘要: The present invention provides for methods of producing transgenic avians which may include delivering a heterologous nucleic acid to oviduct tissue of an avian wherein the nucleic acid enters a cell of the oviduct tissue and is expressed.
摘要翻译: 本发明提供了生产转基因鸟类的方法,其可以包括将异源核酸递送到禽类的输卵管组织,其中核酸进入输卵管组织的细胞并被表达。
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