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    PROTEASE-BASED BIOSENSOR
    5.
    发明申请
    PROTEASE-BASED BIOSENSOR 有权
    基于PROTEASE的生物传感器

    公开(公告)号：US20150226731A1

    公开(公告)日：2015-08-13

    申请号：US14427982

    申请日：2013-09-12

    申请人： THE UNIVERSITY OF QUEENSLAND

    发明人： Kirill Alexandrov ,  Viktor Stein ,  Matt Trau

    IPC分类号： G01N33/542 ,  G01N33/573 ,  C12N9/50

    CPC分类号： G01N33/542 ,  C07K16/3069 ,  C07K16/36 ,  C07K2317/22 ,  C07K2317/569 ,  C07K2319/21 ,  C07K2319/50 ,  C07K2319/70 ,  C12N9/503 ,  C12N9/506 ,  C12N15/62 ,  C12N2770/24022 ,  C12N2770/34022 ,  C12Q1/37 ,  G01N33/532 ,  G01N33/54366 ,  G01N33/573 ,  G01N2333/005 ,  G01N2333/18 ,  G01N2333/96463

    摘要： A biosensor molecule comprises: a protease amino acid sequence; at least one sensor comprising at least one sensor amino acid sequence which is responsive to at least one target molecule; and an inhibitor of the protease activity of said protease amino acid sequence; wherein the biosensor is switchable from a protease active to a protease inactive state, or from a protease inactive to a protease active state when said sensor responds to said target molecule. The biosensor protease may be a protease of a virus such as a Potyvirus or a Flavivirus wherein the inhibitor is an autoinhibitory peptide derived from the virus. The biosensor may respond to the target molecule allosterically or may be cleaved by a target protease molecule.

    摘要翻译： 生物传感器分子包括：蛋白酶氨基酸序列; 至少一个传感器包括至少一个对至少一个靶分子有响应的传感器氨基酸序列; 和所述蛋白酶氨基酸序列的蛋白酶活性的抑制剂; 其中当所述传感器响应于所述靶分子时，所述生物传感器可从蛋白酶活性切换到蛋白酶非活性状态，或从无活性蛋白酶转变为蛋白酶活性状态。 生物传感器蛋白酶可以是诸如Potyvirus或黄病毒病毒的病毒的蛋白酶，其中抑制剂是源自病毒的自身抑制肽。 生物传感器可以变构反应靶分子，或者可以被靶蛋白酶分子切割。

    Methods of inducing an immune response in a host by administering flavivirus immunogens comprising extracellular viral particles composed of the premembrane (prM) and envelope (E) antigens
    6.
    发明授权
    Methods of inducing an immune response in a host by administering flavivirus immunogens comprising extracellular viral particles composed of the premembrane (prM) and envelope (E) antigens 有权
    通过施用包含由前膜（prM）和包膜（E）抗原构成的细胞外病毒颗粒的黄病毒免疫原在宿主中诱导免疫应答的方法

    公开(公告)号：US08728488B2

    公开(公告)日：2014-05-20

    申请号：US13338529

    申请日：2011-12-28

    申请人： Gwong-Jen J. Chang

    发明人： Gwong-Jen J. Chang

    IPC分类号： A61K39/12 ,  C12N7/04

    CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K48/00 ,  A61K2039/53 ,  C07K16/1081 ,  C07K2319/02 ,  C12N2770/24022 ,  C12N2770/24122 ,  C12N2770/24134 ,  C12Q1/701 ,  G01N33/56983 ,  G01N2333/18 ,  Y02A50/386 ,  Y02A50/388 ,  Y02A50/39 ,  Y02A50/53 ,  Y02A50/60

    摘要： The invention encompasses nucleic acid molecules containing transcription units which encode the flavivirus M and E protein antigens. The flaviviruses include Japanese encephalitis virus, dengue, yellow fever virus and St. Louis encephalitis virus. The nucleic acids function to provide the M and E protein antigens when the nucleic acid resides in an appropriate host cell, especially when the host cell is the cell of a subject. The invention also encompasses a vaccine whose active agent is the nucleic acid. The invention further encompasses the cultured host cells when they contain within them nucleic acid molecules containing the transcription units. The invention in addition encompasses a method of immunizing a subject against flavivirus infection by administering to the subject an effective amount of a vaccine containing a nucleic acid molecule containing the transcription unit of the invention.

    摘要翻译： 本发明包括含有编码黄病毒M和E蛋白抗原的转录单位的核酸分子。 黄病毒包括日本脑炎病毒，登革热，黄热病毒和圣路易脑炎病毒。 当核酸位于合适的宿主细胞中时，特别是当宿主细胞是受试者的细胞时，核酸起到提供M和E蛋白抗原的作用。 本发明还包括其活性剂是核酸的疫苗。 本发明还包括当培养的宿主细胞含有含有转录单位的核酸分子时。 本发明另外包括通过向受试者施用含有含有本发明的转录单位的核酸分子的有效量的疫苗免疫受试者免受黄病毒感染的方法。