公开(公告)号：US20050014224A1

公开(公告)日：2005-01-20

申请号：US10853032

申请日：2004-05-24

申请人： Mary Collins ,  Ethan Shevach ,  Rebecca McHugh ,  Matthew Whitters ,  Deborah Young ,  Michael Byrne ,  Padmalatha Reddy ,  Geoffrey Stephens ,  Beatriz Carreno

发明人： Mary Collins ,  Ethan Shevach ,  Rebecca McHugh ,  Matthew Whitters ,  Deborah Young ,  Michael Byrne ,  Padmalatha Reddy ,  Geoffrey Stephens ,  Beatriz Carreno

IPC分类号： A61K38/00 ,  A61K39/00 ,  C07K14/47 ,  C07K14/525 ,  C07K16/24 ,  C07K16/28 ,  G01N33/566 ,  C12P21/02 ,  C07K14/705 ,  C07H21/04

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/525 ,  C07K16/241 ,  C07K16/2866 ,  C07K2317/73 ,  G01N33/566

摘要： The present invention provides novel isolated and purified polynucleotides and polypeptides related to a novel ligand for glucocorticoid-induced TNF receptor (GITR). The invention also provides antibodies to the GITR ligand (GITRL). The present invention also is directed to novel methods for diagnosing, prognosing, monitoring the progress of, and treating disorders arising from disregulation of the immune system (e.g., autoimmune disorders, inflammatory diseases, and transplant rejection, and cancers and infectious diseases) using GITRL and/or modulators of GITRL. The present invention is further directed to novel therapeutics and therapeutic targets and to methods of screening and assessing test compounds for the intervention (treatment) and prevention of said disorders arising from disregulation of the immune system, as related to GITRL and GITR.

摘要翻译： 本发明提供了与糖皮质激素诱导的TNF受体（GITR）的新型配体相关的新型分离和纯化的多核苷酸和多肽。 本发明还提供了对GITR配体（GITRL）的抗体。 本发明还涉及使用GITRL诊断，预后，监测免疫系统失调引起的疾病（例如，自身免疫疾病，炎性疾病和移植排斥，以及癌症和感染性疾病）的新方法 和/或GITRL的调节剂。 本发明还涉及新的治疗学和治疗靶标，以及与GITRL和GITR有关的筛选和评估试验化合物用于干预（治疗）和预防由免疫系统失调引起的所述疾病的方法。

公开(公告)号：US20130157363A1

公开(公告)日：2013-06-20

申请号：US13716900

申请日：2012-12-17

申请人： Yong Chan Kim ,  Ethan Shevach

发明人： Yong Chan Kim ,  Ethan Shevach

IPC分类号： C12N5/0783

CPC分类号： C12N5/0637 ,  A61K35/17 ,  A61K2035/124 ,  C12N5/0636 ,  C12N2501/056 ,  C12N2501/515

摘要： The present invention provides methods for producing cell populations enriched for stable, regulatory T cells (Tregs). In particular, the invention relates to methods for culturing T cells such that the final culture is enriched for stable, regulatory T cells. It also relates to methods for stabilizing regulatory T cells. Also provided are compositions enriched for stable, regulatory T cells, which are useful for treating individuals in need of such treatment. The methods and compositions disclosed herein can also be used to treat an individual suffering from an immune-mediated disease.

摘要翻译： 本发明提供用于产生富含稳定的调节性T细胞（Treg）的细胞群的方法。 特别地，本发明涉及培养T细胞的方法，使得最终培养物富集稳定的调节性T细胞。 它还涉及用于稳定调节性T细胞的方法。 还提供了富含稳定的调节性T细胞的组合物，其可用于治疗需要这种治疗的个体。 本文公开的方法和组合物还可以用于治疗患有免疫介导的疾病的个体。