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公开(公告)号：US20090215091A1
公开(公告)日：2009-08-27
申请号：US12394922
申请日：2009-02-27
申请人： Mary L. Disis , Vivian Goodell , Hailing Lu
发明人： Mary L. Disis , Vivian Goodell , Hailing Lu
IPC分类号： G01N33/574
CPC分类号： G01N33/57407 , G01N33/57473 , G01N2333/4725 , G01N2333/4739 , G01N2333/4745 , G01N2333/4748 , G01N2333/485
摘要： The invention provides a method for detection of a malignancy in a specimen of bodily fluid. The method comprises contacting the specimen with at least two antigens selected from the group consisting of p53, IGFBP2, Topo2α, cathepsin D, cyclin B, cyclin D1, MUC1, HER-2/neu and CEA. The method further comprises incubating the specimen and the antigen for a duration and under conditions that are sufficient for the formation of immunocomplexes; and detecting the presence or absence of immunocomplex formation between the antigens and antibodies specific for the antigens in the specimen, thereby determining the presence or absence of the malignancy. Also provided is a method for monitoring the effectiveness of cancer therapy related to a malignancy in a warm-blooded animal, a method for distinguishing between Stage I and Stage II colorectal cancer in a specimen of bodily fluid.
摘要翻译： 本发明提供一种用于检测体液中的恶性肿瘤的方法。 该方法包括使样品与选自p53，IGFBP2，Topo2alpha，组织蛋白酶D，细胞周期蛋白B，细胞周期蛋白D1，MUC1，HER-2 / neu和CEA的至少两种抗原接触。 该方法还包括在足以形成免疫复合物的条件下温育样品和抗原一段时间; 并检测抗原与样品中抗原特异性抗体之间存在或不存在免疫复合物形成，从而确定恶性肿瘤的存在或不存在。 还提供了用于监测与温血动物相关的恶性肿瘤的癌症治疗的有效性的方法，用于区分体液样本中的I期和II期结肠直肠癌的方法。
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公开(公告)号：US20100092523A1
公开(公告)日：2010-04-15
申请号：US12446953
申请日：2007-11-09
申请人： Mary L. Disis , Vivian Goodell , Hailing Lu , Douglas G. McNeel
发明人： Mary L. Disis , Vivian Goodell , Hailing Lu , Douglas G. McNeel
CPC分类号： A61K39/0011 , A61K38/1754 , A61K38/1796 , A61K39/0005 , G01N33/57488 , G01N2333/475 , G01N2333/65 , G01N2333/72 , G01N2800/52
摘要： The invention provides a method for inhibiting proliferation of cancer cells, as well as methods for detecting and treating various cancers, including cancer of the ovary, breast, prostate and colon. The method comprises contacting a cancer cell with an IGF-related molecule of the invention or administering an IGF-related vaccine to the cancer patient. In one embodiment, the molecule is an immunogenic peptide derived from IGFBP-2 or from IGF1 R. The invention additionally provides methods for detecting and treating cancer using IGF-related molecules.
摘要翻译： 本发明提供了抑制癌细胞增殖的方法，以及用于检测和治疗各种癌症（包括卵巢癌，乳腺癌，前列腺癌和结肠癌）的方法。 该方法包括使癌细胞与本发明的IGF相关分子接触或向癌症患者施用IGF相关疫苗。 在一个实施方案中，该分子是衍生自IGFBP-2或IGF1R的免疫原性肽。本发明另外提供了使用IGF相关分子检测和治疗癌症的方法。
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公开(公告)号：US09060961B2
公开(公告)日：2015-06-23
申请号：US12446953
申请日：2007-11-09
申请人： Mary L. Disis , Vivian Goodell , Hailing Lu , Douglas G. McNeel
发明人： Mary L. Disis , Vivian Goodell , Hailing Lu , Douglas G. McNeel
IPC分类号： A61K38/00 , A61K39/00 , A61K38/17 , G01N33/574
CPC分类号： A61K39/0011 , A61K38/1754 , A61K38/1796 , A61K39/0005 , G01N33/57488 , G01N2333/475 , G01N2333/65 , G01N2333/72 , G01N2800/52
摘要： The invention provides a method for inhibiting proliferation of cancer cells, as well as methods for detecting and treating various cancers, including cancer of the ovary, breast, prostate and colon. The method comprises contacting a cancer cell with an IGF-related molecule of the invention or administering an IGF-related vaccine to the cancer patient. In one embodiment, the molecule is an immunogenic peptide derived from IGFBP-2 or from IGF1 R. The invention additionally provides methods for detecting and treating cancer using IGF-related molecules.
摘要翻译： 本发明提供了抑制癌细胞增殖的方法，以及用于检测和治疗各种癌症（包括卵巢癌，乳腺癌，前列腺癌和结肠癌）的方法。 该方法包括使癌细胞与本发明的IGF相关分子接触或向癌症患者施用IGF相关疫苗。 在一个实施方案中，该分子是衍生自IGFBP-2或IGF1R的免疫原性肽。本发明另外提供了使用IGF相关分子检测和治疗癌症的方法。
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公开(公告)号：US08216789B2
公开(公告)日：2012-07-10
申请号：US12394922
申请日：2009-02-27
申请人： Mary L. Disis , Vivian Goodell , Hailing Lu
发明人： Mary L. Disis , Vivian Goodell , Hailing Lu
IPC分类号： G01N33/53
CPC分类号： G01N33/57407 , G01N33/57473 , G01N2333/4725 , G01N2333/4739 , G01N2333/4745 , G01N2333/4748 , G01N2333/485
摘要： The invention provides a method for detection of a malignancy in a specimen of bodily fluid. The method comprises contacting the specimen with at least two antigens selected from the group consisting of p53, IGFBP2, Topo2α, cathepsin D, cyclin B, cyclin D1, MUC1, HER-2/neu and CEA. The method further comprises incubating the specimen and the antigen for a duration and under conditions that are sufficient for the formation of immunocomplexes; and detecting the presence or absence of immunocomplex formation between the antigens and antibodies specific for the antigens in the specimen, thereby determining the presence or absence of the malignancy. Also provided is a method for monitoring the effectiveness of cancer therapy related to a malignancy in a warm-blooded animal, a method for distinguishing between Stage I and Stage II colorectal cancer in a specimen of bodily fluid.
摘要翻译： 本发明提供一种用于检测体液中的恶性肿瘤的方法。 该方法包括使样品与选自p53，IGFBP2，Topo2α，组织蛋白酶D，细胞周期蛋白B，细胞周期蛋白D1，MUC1，HER-2 / neu和CEA的至少两种抗原接触。 该方法还包括在足以形成免疫复合物的条件下温育样品和抗原一段时间; 并检测抗原与样品中抗原特异性抗体之间存在或不存在免疫复合物形成，从而确定恶性肿瘤的存在或不存在。 还提供了用于监测与温血动物相关的恶性肿瘤的癌症治疗的有效性的方法，用于区分体液样本中的I期和II期结肠直肠癌的方法。
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