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公开(公告)号：US11802148B2
公开(公告)日：2023-10-31
申请号：US17528946
申请日：2021-11-17
申请人： Diadem S.r.l.
CPC分类号： C07K16/18 , C07K16/32 , G01N33/6896 , C07K2317/34 , G01N2333/4748 , G01N2800/2821 , G01N2800/56 , G01N2800/7042
摘要： The invention relates to an anti-human p53 antibody suitable for specifically binding a linear epitope which is exposed only in a conformationally altered isoform of the characteristic p53 protein of patients with Alzheimer's disease or prone to develop Alzheimer's disease or cognitive impairment during ageing. Methods and diagnostic and prognostic kits are also described.
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公开(公告)号：US20230258646A1
公开(公告)日：2023-08-17
申请号：US18131559
申请日：2023-04-06
发明人： Harry OSTRER , Johnny C. LOKE , Alexander PEARLMAN
IPC分类号： G01N33/574 , C12Q1/6886
CPC分类号： G01N33/57496 , C12Q1/6886 , G01N33/57484 , G01N33/57415 , G01N33/57449 , C12Q2600/156 , G01N2333/4748 , G01N2440/14 , G01N2800/50 , G01N2333/4703 , G01N2333/9108
摘要： Heritable mutations in the BRCA1 and BRCA2 and other genes in the DNA double-strand break (DSB) repair pathway increase risk of breast, ovarian and other cancers. In response to DNA breaks, the proteins encoded by these genes bind to each other and are transported into the nucleus to form nuclear foci and initiate homologous recombination. Flow cytometry-based functional variant analyses (FVAs) were developed to determine whether variants in BRCA1 or other DSB repair genes disrupted the binding of BRCA1 to its protein partners, the phosphorylation of p53 or the transport of the BRCA1complex to the nucleus in response to DNA damage. Each of these assays distinguished high-risk BRCA1 mutations from low-risk BRCA1 controls. Mutations in other DSB repair pathway genes produced molecular phenocopies with these assays. FVA assays may represent an adjunct to sequencing for categorizing VUS or may represent a stand-alone measure for assessing breast cancer risk.
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公开(公告)号：US20230220491A1
公开(公告)日：2023-07-13
申请号：US18157597
申请日：2023-01-20
申请人： Genentech, Inc.
发明人： YounJeong CHOI , Omar Kabbarah , Doris Kim
IPC分类号： C12Q1/6886 , A61K39/395 , C07K16/30 , A61K31/517 , C07K16/18 , G01N33/574 , C07K16/28 , A61K45/06
CPC分类号： C12Q1/6886 , A61K39/39558 , C07K16/3038 , A61K31/517 , C07K16/18 , G01N33/57407 , C07K16/2863 , A61K45/06 , G01N2333/71 , C12Q2600/158 , C12Q2600/118 , C12Q2600/106 , G01N2800/52 , G01N2333/4748
摘要： The invention provides methods and compositions to detect expression of one or more biomarkers, including FGFR3, TP53, and/or EGFR, for treating, diagnosing, and providing a prognosis for cancer, e.g., bladder cancer. The invention also provides kits and articles of manufacture for use in the methods.
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公开(公告)号：US20190183856A1
公开(公告)日：2019-06-20
申请号：US15846129
申请日：2017-12-18
发明人： Wenzhe MA , Ying XIE , Xiaolin LIAO , Jiajun HUANG , Wanjun LIN , Ze LONG
IPC分类号： A61K31/381 , A61P35/00 , G01N33/574
CPC分类号： A61K31/381 , A61P35/00 , G01N33/57419 , G01N2333/4748
摘要： One embodiment relates to a method of treating cancer by administering a compound of Formula I to a patient. Another embodiment relates to a method of treating a patient having cancer associated p53 mutation that includes administering to a patient the compound represented by the Formula I:
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5.发明授权公开(公告)号：US09758826B2
公开(公告)日：2017-09-12
申请号：US13163326
申请日：2011-06-17
申请人： Yoko Mullen , Masato Mitsuhashi , Keiko Omori
发明人： Yoko Mullen , Masato Mitsuhashi , Keiko Omori
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/507 , G01N2333/4748 , G01N2333/525
摘要： p53-upregulated modulator of apoptosis (PUMA) is a biomarker associated with islet cell health. If PUMA is low, islet cells are typically healthy. If PUMA is high, islet cells are typically unhealthy or dying. PUMA may be measured by either measuring its nucleic or amino acid. PUMA mRNA may be induced by TNF-α stimulation in a time- and dose-dependent manner and β cell apoptosis is induced through a mitochondrial pathway. TNF-α significantly inhibited glucose-induced preproinsulin precursor mRNA synthesis. Such β cell stress signaling in human islets indicates overall state of islet health and, ultimately, the risk of onset and/or degree of severity of both type 1 and type 2 diabetes mellitus.
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6.发明申请公开(公告)号：US20170211072A1
公开(公告)日：2017-07-27
申请号：US15321561
申请日：2015-06-25
发明人： Raffaella Sordella , Serif Senturk , Luca Cartegni
IPC分类号： C12N15/113 , A61K31/713 , G01N33/574 , A61K38/13 , A61K45/06
CPC分类号： C12N15/1137 , A61K31/198 , A61K31/445 , A61K31/713 , A61K38/13 , A61K45/06 , C12N2310/11 , C12N2310/14 , C12N2310/20 , C12N2320/30 , C12N2320/31 , C12Y502/01008 , G01N33/574 , G01N33/57407 , G01N33/57496 , G01N2333/4748 , G01N2800/52 , A61K2300/00
摘要： Provided herein are methods and compositions for inhibiting epithelial to mesenchymal transition of a cell.
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公开(公告)号：US20170128533A1
公开(公告)日：2017-05-11
申请号：US15413949
申请日：2017-01-24
发明人： Andrei V. Gudkov
CPC分类号： A61K38/1841 , A61K31/355 , A61K31/568 , A61K31/661 , A61K38/164 , A61K38/18 , A61K38/19 , A61K45/06 , C07K14/255 , G01N33/502 , G01N2333/4703 , G01N2333/4748 , G01N2333/495 , G01N2500/00 , Y02A50/481 , A61K2300/00
摘要： The use and screening of modulators of apoptosis is disclosed. The modulators may be, for example, modulator of NF-κB activity. The modulators may be used, for example, in the treatment of NF-κB-mediated diseases, conditions, and injuries.
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8.发明申请Methods And Marker Combinations For Screening For Predisposition To Lung Cancer 审中-公开方法和标记组合筛查肺癌的倾向公开(公告)号：US20160320393A1
公开(公告)日：2016-11-03
申请号：US15151465
申请日：2016-05-10
发明人： Tracey Colpitts , Eric L. Russell , Stephen Frost , Javier Ramirez , Bhawani Singh , John C. Russell
IPC分类号： G01N33/574
CPC分类号： G01N33/57423 , C07K14/4738 , G01N2333/47 , G01N2333/4703 , G01N2333/4725 , G01N2333/4739 , G01N2333/4742 , G01N2333/4748 , G01N2333/705 , G01N2333/70596 , G01N2333/775 , G01N2333/8125 , G01N2333/91205
摘要： The present invention relates to rapid, sensitive methods for determining whether a subject is at risk of developing lung cancer or has lung cancer based on certain combinations or biomarkers or biomarkers and biometric parameters.
摘要翻译： 本发明涉及用于确定受试者是否处于基于某些组合或生物标志物或生物标志物和生物测定参数发展为肺癌或具有肺癌的风险的快速，敏感的方法。
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公开(公告)号：US20160195535A1
公开(公告)日：2016-07-07
申请号：US14653562
申请日：2013-12-18
IPC分类号： G01N33/574 , C07K16/18
CPC分类号： G01N33/57434 , C07K16/18 , G01N2333/435 , G01N2333/4703 , G01N2333/4742 , G01N2333/4748
摘要： The purpose of the present invention is to provide a method for detecting prostatic basal cells by searching for molecules that are expressed specifically in prostatic basal cells and analyzing said molecules. The problem can be solved using a method for detecting prostatic basal cells that is characterized by using immunohistochemical staining to visualize the expression of TRIM29 (Tripartite motif-containing protein 29) protein in prostatic basal cells.
摘要翻译： 本发明的目的是提供一种通过搜索在前列腺基底细胞中特异性表达并分析所述分子的分子来检测前列腺基底细胞的方法。 使用检测前列腺基底细胞的方法可以解决问题，其特征在于使用免疫组织化学染色来观察前列腺基底细胞中TRIM29（含三聚体基序的蛋白29）蛋白的表达。
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10.发明授权Methods and marker combinations for screening for predisposition to lung cancer 有权用于筛选肺癌易感性的方法和标记物组合公开(公告)号：US09347945B2
公开(公告)日：2016-05-24
申请号：US11771727
申请日：2007-06-29
申请人： Tracey Colpitts , Eric L. Russell , Stephen Frost , Javier Ramirez , Bhawani Singh , John C. Russell
发明人： Tracey Colpitts , Eric L. Russell , Stephen Frost , Javier Ramirez , Bhawani Singh , John C. Russell
IPC分类号： G01N33/53 , G01N33/574 , C07K14/47
CPC分类号： G01N33/57423 , C07K14/4738 , G01N2333/47 , G01N2333/4703 , G01N2333/4725 , G01N2333/4739 , G01N2333/4742 , G01N2333/4748 , G01N2333/705 , G01N2333/70596 , G01N2333/775 , G01N2333/8125 , G01N2333/91205
摘要： The present invention relates to rapid, sensitive methods for determining whether a subject is at risk of developing lung cancer or has lung cancer based on certain combinations or biomarkers or biomarkers and biometric parameters.
摘要翻译： 本发明涉及用于确定受试者是否处于基于某些组合或生物标志物或生物标志物和生物测定参数发展为肺癌或具有肺癌的风险的快速，敏感的方法。
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