公开(公告)号：US20090112146A1

公开(公告)日：2009-04-30

申请号：US11928881

申请日：2007-10-30

申请人： Mary Lou Wratten ,  Mauro Atti ,  Antonio Santoro

发明人： Mary Lou Wratten ,  Mauro Atti ,  Antonio Santoro

IPC分类号： A61M1/36

CPC分类号： A61M1/3472 ,  A61M1/3486 ,  A61M1/3679 ,  A61M2202/0417 ,  A61M2202/0445

摘要： Circulating free lambda and kappa free light chains in blood play a role in the pathogenesis of acute renal failure due to myeloma. Coupled plasma filtration and adsorption allows separation of plasma from blood and treatment of the plasma through a cartridge containing a sorbent or resin material, such as hydrophobic divinylbenzene styrenic resins having an average bead diameter of 75 microns, an average pore diameter of 30 nm, and a surface area of 700 m2/g. Lambda and kappa free light chain concentrations progressively decrease during coupled plasma filtration and adsorption treatment resulting in significant reductions by the end of the treatment.

摘要翻译： 在血液中循环游离的λ和κ免费轻链在骨髓瘤引起的急性肾衰竭的发病机理中起作用。 耦合的等离子体过滤和吸附允许将血浆与血液分离并通过包含吸附剂或树脂材料的药筒（例如平均珠粒直径为75微米，平均孔径为30nm的疏水性二乙烯基苯苯乙烯类树脂）以及 表面积为700平方米/克。 在耦合等离子体过滤和吸附处理期间，λ和κ无关轻链浓度逐渐降低，导致治疗结束时显着降低。

公开(公告)号：US08672869B2

公开(公告)日：2014-03-18

申请号：US11928881

申请日：2007-10-30

申请人： Mary Lou Wratten ,  Mauro Atti ,  Antonio Santoro

发明人： Mary Lou Wratten ,  Mauro Atti ,  Antonio Santoro

IPC分类号： A61M1/14 ,  A61M1/34

CPC分类号： A61M1/3472 ,  A61M1/3486 ,  A61M1/3679 ,  A61M2202/0417 ,  A61M2202/0445

摘要： Circulating free lambda and kappa free light chains in blood play a role in the pathogenesis of acute renal failure due to myeloma. Coupled plasma filtration and adsorption allows separation of plasma from blood and treatment of the plasma through a cartridge containing a sorbent or resin material, such as hydrophobic divinylbenzene styrenic resins having an average bead diameter of 75 microns, an average pore diameter of 30 nm, and a surface area of 700 m2/g. Lambda and kappa free light chain concentrations progressively decrease during coupled plasma filtration and adsorption treatment resulting in significant reductions by the end of the treatment.

摘要翻译： 在血液中循环游离的λ和κ免费轻链在骨髓瘤引起的急性肾衰竭的发病机理中起作用。 耦合的等离子体过滤和吸附允许将血浆与血液分离并通过包含吸附剂或树脂材料的药筒（例如平均珠粒直径为75微米，平均孔径为30nm的疏水性二乙烯基苯苯乙烯类树脂）以及 表面积为700平方米/克。 在耦合等离子体过滤和吸附处理期间，λ和κ无关轻链浓度逐渐降低，导致治疗结束时显着降低。