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27 条记录 (耗时 0.016 秒)

    Solid pharmaceutical preparation
    1.
    发明授权
    Solid pharmaceutical preparation 有权
    固体药物制剂

    公开(公告)号：US08263121B2

    公开(公告)日：2012-09-11

    申请号：US11578450

    申请日：2005-04-13

    申请人： Masahiko Koike ,  Hiroyoshi Koyama ,  Naoru Hamaguchi

    发明人： Masahiko Koike ,  Hiroyoshi Koyama ,  Naoru Hamaguchi

    IPC分类号： A61K31/4439 ,  A61K31/155 ,  A61K9/201

    CPC分类号： A61K9/209 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2853 ,  A61K9/2866 ,  A61K31/155 ,  A61K31/4439 ,  A61K45/06 ,  A61K2300/00

    摘要： The present invention provides a solid preparation containing an insulin sensitizer and an active ingredient (except insulin sensitizers), which shows in vivo dissolution behavior of an insulin sensitizer, which is similar to the dissolution behavior of an insulin sensitizer from “a solid preparation containing an insulin sensitizer alone as an active ingredient”.The present invention provides a solid preparation containing (1) a layer containing an insulin sensitizer, and (2) a layer containing (a) an active ingredient (except insulin sensitizers), (b) microcrystalline cellulose having a mean particle size of 5-25 μm, (c) microcrystalline cellulose having a mean particle size of 30-100 μm and (d) polyvinylpyrrolidone K-90.

    摘要翻译： 本发明提供了含有胰岛素敏化剂和活性成分（胰岛素敏化剂除外）的固体制剂，其显示胰岛素敏化剂的体内溶出行为，其类似于胰岛素敏化剂从“含有 单独的胰岛素敏化剂作为活性成分“。 本发明提供一种固体制剂，其含有（1）含有胰岛素敏化剂的层，和（2）含有（a）活性成分（胰岛素敏化剂除外）的层，（b）平均粒径为5〜 25μm，（c）平均粒径为30-100μm的微晶纤维素和（d）聚乙烯吡咯烷酮K-90。

    TABLET
    3.
    发明申请
    TABLET 有权
    片剂

    公开(公告)号：US20110189282A1

    公开(公告)日：2011-08-04

    申请号：US13082890

    申请日：2011-04-08

    申请人： Masahiko Koike ,  Hiroyoshi Koyama

    发明人： Masahiko Koike ,  Hiroyoshi Koyama

    IPC分类号： A61K9/28

    CPC分类号： A61K9/2072

    摘要： The present invention can retain the volume of a tablet large without increasing the thickness of the tablet or the like dimension and prevents a plurality of tablets from sticking to each other even if they are subjected to a film-coating or the like treatment, so as to improve the yield. The tablet is a tablet (1) longer in one direction when seen in plan. The tablet (1) has side edges (6) each of which extends in a longitudinal direction and is formed in the shape of a curve projecting outwardly in plan view. The curve has a radius of curvature (R1) set to at least 1.5 times a length (L) of the tablet. This makes a projected area of the tablet (1) in plan view at least 97% with respect to a projected area of a standard elliptical tablet having opposite end portions each of which is formed by a semi-circle having a diameter of a width (W) of the tablet.

    摘要翻译： 本发明可以在不增加片剂厚度等的情况下保持片剂的体积，并且即使进行薄膜包衣或类似的处理，也可以防止多个片剂彼此粘附，从而 提高产量。 平板电脑是平板电脑（1）在计划中看到的时间长一个方向。 片剂（1）具有侧边缘（6），每个边缘沿纵向方向延伸并且形成为在平面图中向外突出的曲线形状。 曲线的曲率半径（R1）设定为片剂长度（L）的至少1.5倍。 这使得平面图（1）中的平板（1）的投影面积相对于具有相对端部的标准椭圆形片的投影面积至少为97％，每个端部均由直径为宽度的半圆形成 W）。

    Tablet
    6.
    发明授权
    Tablet 有权
    片剂

    公开(公告)号：US09320714B2

    公开(公告)日：2016-04-26

    申请号：US13082890

    申请日：2011-04-08

    申请人： Masahiko Koike ,  Hiroyoshi Koyama

    发明人： Masahiko Koike ,  Hiroyoshi Koyama

    IPC分类号： A61K9/28 ,  A61K9/20

    CPC分类号： A61K9/2072

    摘要： The present invention can retain the volume of a tablet large without increasing the thickness of the tablet or the like dimension and prevents a plurality of tablets from sticking to each other even if they are subjected to a film-coating or the like treatment, so as to improve the yield. The tablet is a tablet (1) longer in one direction when seen in plan. The tablet (1) has side edges (6) each of which extends in a longitudinal direction and is formed in the shape of a curve projecting outwardly in plan view. The curve has a radius of curvature (R1) set to at least 1.5 times a length (L) of the tablet. This makes a projected area of the tablet (1) in plan view at least 97% with respect to a projected area of a standard elliptical tablet having opposite end portions each of which is formed by a semi-circle having a diameter of a width (W) of the tablet.

    摘要翻译： 本发明可以在不增加片剂厚度等的情况下保持片剂的体积，并且即使进行薄膜包衣或类似的处理也能防止多个片剂彼此粘附，因此 提高产量。 平板电脑是平板电脑（1）在计划中看到的时间长一个方向。 片剂（1）具有侧边缘（6），每个边缘沿纵向方向延伸并且形成为在平面图中向外突出的曲线形状。 曲线的曲率半径（R1）设定为片剂长度（L）的至少1.5倍。 这使得平面图（1）中的平板（1）的投影面积相对于具有相对端部的标准椭圆形片的投影面积至少为97％，每个端部均由直径为宽度的半圆形成 W）。

    Key range dividing type electronic musical instrument
    9.
    发明授权
    Key range dividing type electronic musical instrument 失效
    键范围分类电子乐器

    公开(公告)号：US4191082A

    公开(公告)日：1980-03-04

    申请号：US950328

    申请日：1978-10-11

    申请人： Masahiko Koike

    发明人： Masahiko Koike

    IPC分类号： G10H1/06 ,  G10H1/18 ,  G10H1/02

    CPC分类号： G10H1/06 ,  G10H1/18 ,  Y10S84/09

    摘要： An electronic musical instrument having the key range divided into upper and lower divisions, including a logical circuit converting the change-over position outputs of a key range dividing position selecting switch into gate control signals specifying corresponding key range dividing positions and a plurality of gates controlled by these gate control signals, thereby controlling the distributive mode of keyed tone signals to different tone color filters.

    摘要翻译： 一种电子乐器，具有分为上下分割的键范围，包括将键范围分割位置选择开关的转换位置输出转换为指定对应键范围分割位置的门控制信号和多个门控制的逻辑电路 通过这些门控制信号，从而将键控音调信号的分配模式控制到不同的音调滤色器。

    Aqueous suspension of agrochemical
    10.
    发明授权
    Aqueous suspension of agrochemical 失效
    农药的水悬浮液

    公开(公告)号：US06306414B1

    公开(公告)日：2001-10-23

    申请号：US09341813

    申请日：1999-07-19

    申请人： Masahiko Koike

    发明人： Masahiko Koike

    IPC分类号： A01N2502

    CPC分类号： A01N51/00 ,  A01N25/04 ,  A01N25/10 ,  A01N25/30 ,  A01N2300/00

    摘要： The present invention relates to an aqueous suspension comprising (i) a compound of the formula: or a salt thereof, (ii) a condensate of formaldehyde with an aromatic sulfonic acid or a salt thereof or a polyoxyalkylene allyl phenyl ether sulfate, and (iii) an absorptive water-soluble polymer. The aqueous suspension of the invention can be used with advantage as a stable aqueous suspension of low viscosity providing for excellent delivery from a container, with excellent dispersibility in diluent water and excellent long-term fluidity free from caking due to precipitation of the suspended particles.

    摘要翻译： 本发明涉及一种水性悬浮液，其包含（i）下式化合物或其盐，（ii）甲醛与芳族磺酸或其盐或聚氧化烯烯丙基苯基醚硫酸盐的缩合物，和（iii） ）吸收性水溶性聚合物。 本发明的水性悬浮液可以有利地用作低粘度的稳定的水性悬浮液，其提供了从容器的良好输送，在稀释水中具有优异的分散性，并且由于悬浮颗粒的沉淀而具有优异的长期流动性。