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1.发明申请公开(公告)号：US20130011366A1
公开(公告)日：2013-01-10
申请号：US13604645
申请日：2012-09-06
申请人： Masaji Okada , Yasushi Takamori , Kazuyuki Ogawa , Kinya Nagata
发明人： Masaji Okada , Yasushi Takamori , Kazuyuki Ogawa , Kinya Nagata
CPC分类号： A61K38/20 , A61K38/164 , A61K38/1709 , A61K38/1729 , A61K38/204 , A61K38/208 , A61K39/04 , A61K2300/00
摘要： (Problems)To provide a therapeutic agent for infections comprising granulysin as an active ingredient which has little side effect and no cytotoxicity and to which bacteria can hardly acquire resistance, and a treatment method using the same.(Means for solving problems)The present invention provides a therapeutic agent for infections comprising as active ingredient: 15K granulysin, a combination of 15K granulysin and 15K granulysin in vivo expression vector, a combination of 15K granulysin and at least one interleukin selected from IL-6, IL-23 or IL-27, a combination of 15K granulysin in vivo expression vector and at least one interleukin selected from IL-6, IL-23 or IL-27, or a combination of 15K granulysin in vivo expression vector and HSP65DNA and IL-12DNA in vivo expression vector, which enhances killing effects on bacteria and has less side effect, and to which bacteria can hardly acquire resistance, and a treatment method using the same.
摘要翻译： （问题）为了提供包含颗粒溶素作为活性成分的感染治疗剂，其副作用小，无细胞毒性，细菌几乎不能获得抗性，以及使用该治疗剂的治疗方法。 （解决问题的手段）本发明提供一种感染用治疗剂，其包含作为活性成分的15K颗粒溶素，15K颗粒溶素和15K颗粒溶素在体内表达载体的组合，15K颗粒溶素与至少一种选自IL- 6，IL-23或IL-27，15K颗粒溶素在体内表达载体和选自IL-6，IL-23或IL-27中的至少一种白介素或15K颗粒溶素的体内表达载体和HSP65DNA的组合的组合 和IL-12DNA体内表达载体，其对细菌的杀伤作用增强，副作用较小，细菌几乎不能获得抗性，以及使用其的处理方法。
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公开(公告)号：US20050239699A1
公开(公告)日：2005-10-27
申请号：US10921091
申请日：2004-08-17
申请人： Masaji Okada , Yasushi Takamori , Kazuyuki Ogawa , Kinya Nagata
发明人： Masaji Okada , Yasushi Takamori , Kazuyuki Ogawa , Kinya Nagata
IPC分类号： C12N15/09 , A61K38/00 , A61K38/16 , A61K38/17 , A61K48/00 , A61P31/04 , A61P31/06 , C07K14/47
CPC分类号： A61K38/16 , A61K38/1709
摘要： According to the present invention, there is provided a remedy for infections containing 15K granulysin as an active ingredient, which has no perceived side effect, and is effective.
摘要翻译： 根据本发明，提供了含有15K颗粒溶素作为活性成分的感染的补救剂，其没有察觉到副作用，并且是有效的。
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公开(公告)号：US08288509B2
公开(公告)日：2012-10-16
申请号：US12386974
申请日：2009-04-24
申请人： Masaji Okada , Yasushi Takamori , Kazuyuki Ogawa , Kinya Nagata
发明人： Masaji Okada , Yasushi Takamori , Kazuyuki Ogawa , Kinya Nagata
CPC分类号： A61K38/20 , A61K38/164 , A61K38/1709 , A61K38/1729 , A61K38/204 , A61K38/208 , A61K39/04 , A61K2300/00
摘要： (Problems)To provide a therapeutic agent for infections comprising granulysin as an active ingredient which has little side effect and no cytotoxicity and to which bacteria can hardly acquire resistance, and a treatment method using the same.(Means for Solving Problems)The present invention provides a therapeutic agent for infections comprising as active ingredient: 15K granulysin, a combination of 15K granulysin and 15K granulysin in vivo expression vector, a combination of 15K granulysin and at least one interleukin selected from IL-6, IL-23 or IL-27, a combination of 15K granulysin in vivo expression vector and at least one interleukin selected from IL-6, IL-23 or IL-27, or a combination of 15K granulysin in vivo expression vector and HSP65DNA and IL-12DNA in vivo expression vector, which enhances killing effects on bacteria and has less side effect, and to which bacteria can hardly acquire resistance, and a treatment method using the same.
摘要翻译： （问题）为了提供包含颗粒溶素作为活性成分的感染治疗剂，其副作用小，无细胞毒性，细菌几乎不能获得抗性，以及使用该治疗剂的治疗方法。 （解决问题的手段）本发明提供一种感染治疗剂，其包含15K颗粒溶素，15K颗粒溶素和15K颗粒溶素在体内表达载体的组合，15K颗粒溶素与至少一种选自IL- 6，IL-23或IL-27，15K颗粒溶素在体内表达载体和选自IL-6，IL-23或IL-27中的至少一种白介素或15K颗粒溶素的体内表达载体和HSP65DNA的组合的组合 和IL-12DNA体内表达载体，其对细菌的杀伤作用增强，副作用较小，细菌几乎不能获得抗性，以及使用其的处理方法。
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公开(公告)号：US20090274651A1
公开(公告)日：2009-11-05
申请号：US12386974
申请日：2009-04-24
申请人： Masaji Okada , Yasushi Takamori , Kazuyuki Ogawa , Kinya Nagata
发明人： Masaji Okada , Yasushi Takamori , Kazuyuki Ogawa , Kinya Nagata
IPC分类号： A61K38/20 , C07K14/47 , A61K38/16 , A61K31/711 , A61P31/06
CPC分类号： A61K38/20 , A61K38/164 , A61K38/1709 , A61K38/1729 , A61K38/204 , A61K38/208 , A61K39/04 , A61K2300/00
摘要： (Problems) To provide a therapeutic agent for infections comprising granulysin as an active ingredient which has little side effect and no cytotoxicity and to which bacteria can hardly acquire resistance, and a treatment method using the same. (Means for Solving Problems) The present invention provides a therapeutic agent for infections comprising as active ingredient: 15K granulysin, a combination of 15K granulysin and 15K granulysin in vivo expression vector, a combination of 15K granulysin and at least one interleukin selected from IL-6, IL-23 or IL-27, a combination of 15K granulysin in vivo expression vector and at least one interleukin selected from IL-6, IL-23 or IL-27, or a combination of 15K granulysin in vivo expression vector and HSP65DNA and IL-12DNA in vivo expression vector, which enhances killing effects on bacteria and has less side effect, and to which bacteria can hardly acquire resistance, and a treatment method using the same.
摘要翻译： （问题）为了提供包含颗粒溶素作为活性成分的感染治疗剂，其副作用小，无细胞毒性，细菌几乎不能获得抗性，以及使用该治疗剂的治疗方法。 （解决问题的手段）本发明提供一种感染治疗剂，其包含15K颗粒溶素，15K颗粒溶素和15K颗粒溶素在体内表达载体的组合，15K颗粒溶素与至少一种选自IL- 6，IL-23或IL-27，15K颗粒溶素在体内表达载体和选自IL-6，IL-23或IL-27中的至少一种白介素或15K颗粒溶素的体内表达载体和HSP65DNA的组合的组合 和IL-12DNA体内表达载体，其对细菌的杀伤作用增强，副作用较小，细菌几乎不能获得抗性，以及使用其的处理方法。
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公开(公告)号：US20140308240A1
公开(公告)日：2014-10-16
申请号：US14292940
申请日：2014-06-02
申请人： MASAJI OKADA (27%) , YASUSHI TAKAMORI (20%) , NATIONAL HOSPITAL ORGANIZATION, KINKI-CHUO CHEST MEDICAL CENTER (27%) , AZBIO CORPORATION (26%)
发明人： Masaji Okada , Yasushi Takamori , Kazuyuki Ogawa , Kinya Nagata
CPC分类号： A61K38/20 , A61K38/164 , A61K38/1709 , A61K38/1729 , A61K38/204 , A61K38/208 , A61K39/04 , A61K2300/00
摘要： (Problems) To provide a therapeutic agent for infections comprising granulysin as an active ingredient which has little side effect and no cytotoxicity and to which bacteria can hardly acquire resistance, and a treatment method using the same.(Means for Solving Problems) The present invention provides a therapeutic agent for infections comprising as active ingredient: 15K granulysin, a combination of 15K granulysin and 15K granulysin in vivo expression vector, a combination of 15K granulysin and at least one interleukin selected from IL-6, IL-23 or IL-27, a combination of 15K granulysin in vivo expression vector and at least one interleukin selected from IL-6, IL-23 or IL-27, or a combination of 15K granulysin in vivo expression vector and HSP65DNA and IL-12DNA in vivo expression vector, which enhances killing effects on bacteria and has less side effect, and to which bacteria can hardly acquire resistance, and a treatment method using the same.
摘要翻译： （问题）为了提供包含颗粒溶素作为活性成分的感染治疗剂，其副作用小，无细胞毒性，细菌几乎不能获得抗性，以及使用该治疗剂的治疗方法。 （解决问题的手段）本发明提供一种感染治疗剂，其包含15K颗粒溶素，15K颗粒溶素和15K颗粒溶素在体内表达载体的组合，15K颗粒溶素与至少一种选自IL- 6，IL-23或IL-27，15K颗粒溶素在体内表达载体和选自IL-6，IL-23或IL-27中的至少一种白介素或15K颗粒溶素的体内表达载体和HSP65DNA的组合的组合 和IL-12DNA体内表达载体，其对细菌的杀伤作用增强，副作用较小，细菌几乎不能获得抗性，以及使用其的处理方法。
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公开(公告)号：US09233142B2
公开(公告)日：2016-01-12
申请号：US14292940
申请日：2014-06-02
申请人： NATIONAL HOSPITAL ORGANIZATION, KINKI-CHUO CHEST MEDICAL CENTER, partial interest , AZBIO CORPORATION, partial interest , Masaji Okada, partial interest , Yasushi Takamori, partial interest
发明人： Masaji Okada , Yasushi Takamori , Kazuyuki Ogawa , Kinya Nagata
CPC分类号： A61K38/20 , A61K38/164 , A61K38/1709 , A61K38/1729 , A61K38/204 , A61K38/208 , A61K39/04 , A61K2300/00
摘要： (Problems) To provide a therapeutic agent for infections comprising granulysin as an active ingredient which has little side effect and no cytotoxicity and to which bacteria can hardly acquire resistance, and a treatment method using the same.(Means for Solving Problems) The present invention provides a therapeutic agent for infections comprising as active ingredient: 15K granulysin, a combination of 15K granulysin and 15K granulysin in vivo expression vector, a combination of 15K granulysin and at least one interleukin selected from IL-6, IL-23 or IL-27, a combination of 15K granulysin in vivo expression vector and at least one interleukin selected from IL-6, IL-23 or IL-27, or a combination of 15K granulysin in vivo expression vector and HSP65DNA and IL-12DNA in vivo expression vector, which enhances killing effects on bacteria and has less side effect, and to which bacteria can hardly acquire resistance, and a treatment method using the same.
摘要翻译： （问题）为了提供包含颗粒溶素作为活性成分的感染治疗剂，其副作用小，无细胞毒性，细菌几乎不能获得抗性，以及使用该治疗剂的治疗方法。 （解决问题的手段）本发明提供一种感染治疗剂，其包含15K颗粒溶素，15K颗粒溶素和15K颗粒溶素在体内表达载体的组合，15K颗粒溶素与至少一种选自IL- 6，IL-23或IL-27，15K颗粒溶素在体内表达载体和选自IL-6，IL-23或IL-27中的至少一种白介素或15K颗粒溶素的体内表达载体和HSP65DNA的组合的组合 和IL-12DNA体内表达载体，其对细菌的杀伤作用增强，副作用较小，细菌几乎不能获得抗性，以及使用其的处理方法。
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