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公开(公告)号：US20050090531A1
公开(公告)日：2005-04-28
申请号：US10969885
申请日：2004-10-22
IPC分类号： A61K31/4164 , A61K31/4174 , A61K31/4439 , A61P25/28 , C07D521/00 , C07D43/02
CPC分类号： C07D249/08 , A61K31/4164 , A61K31/4174 , A61K31/4439 , C07D231/12 , C07D233/56
摘要： The MAG expression promoter of the present invention contains a compound of the formula (I) wherein each symbol is as defined in the specification, an optically active form thereof or a pharmaceutically acceptable salt thereof. As a compound of the formula (1), 4-[α-hydroxy-5-(1-imidazolyl)-2-methylbenzyl]-3,5-dimethylbenzoic acid is exemplified. The MAG expression promoter of the present invention is useful as an agent for the prophylaxis and/or treatment of a disease of mammals inclusive of humans, which mainly presents hypomyelination, further, dysmyelination or demyelination.
摘要翻译： 本发明的MAG表达启动子含有式（I）化合物，其中每个符号如说明书中所定义，其光学活性形式或其药学上可接受的盐。 作为式（1）的化合物，例举了4- [α-羟基-5-（1-咪唑基）-2-甲基苄基] -3,5-二甲基苯甲酸。 本发明的MAG表达启动子可用作预防和/或治疗包括人类在内的哺乳动物疾病的药剂，其主要表现为脱髓鞘，进一步发生脱髓鞘或脱髓鞘。
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公开(公告)号：US07166630B2
公开(公告)日：2007-01-23
申请号：US10969885
申请日：2004-10-22
IPC分类号： A61K31/4164
CPC分类号： C07D249/08 , A61K31/4164 , A61K31/4174 , A61K31/4439 , C07D231/12 , C07D233/56
摘要： A method for promoting myelination of an axon comprising administering 4-[α-hydroxy-5-(1-imidazolyl)-2-methylbenzyl]-3,5-dimethylbenzoic acid is disclosed.
摘要翻译： 一种促进轴突髓鞘形成的方法，包括给予4- [α-羟基-5-（1-咪唑基）-2-甲基苄基] -3,5-二甲基苯甲酸。
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公开(公告)号：US20060270712A1
公开(公告)日：2006-11-30
申请号：US11499785
申请日：2006-08-07
IPC分类号： A61K31/4439 , A61K31/4164
CPC分类号： C07D249/08 , A61K31/4164 , A61K31/4174 , A61K31/4439 , C07D231/12 , C07D233/56
摘要： The MAG expression promoter of the present invention contains a compound of the formula (I) wherein each symbol is as defined in the specification, an optically active form thereof or a pharmaceutically acceptable salt thereof. As a compound of the formula (I), 4-[α-hydroxy-5-(1-imidazolyl)-2-methylbenzyl]-3,5-dimethylbenzoic acid is exemplified. The MAG expression promoter of the present invention is useful as an agent for the prophylaxis and/or treatment of a disease of mammals inclusive of human, which mainly presents hypomyelination, further, dysmyelination or demyelination.
摘要翻译： 本发明的MAG表达启动子含有式（I）化合物，其中每个符号如说明书中所定义，其光学活性形式或其药学上可接受的盐。 作为式（I）的化合物，例举了4- [α-羟基-5-（1-咪唑基）-2-甲基苄基] -3,5-二甲基苯甲酸。 本发明的MAG表达启动子可用作预防和/或治疗包括人类在内的哺乳动物疾病的药剂，其主要表现为鞘内脱髓鞘，进一步脱髓鞘或脱髓鞘。
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4.发明授权Power plant control device which uses a model, a learning signal, a correction signal, and a manipulation signal 有权使用模型，学习信号，校正信号和操作信号的发电厂控制装置公开(公告)号：US08554706B2
公开(公告)日：2013-10-08
申请号：US13415876
申请日：2012-03-09
CPC分类号： G05B13/027
摘要： A gas concentration estimation device of a coal-burning boiler adapted to estimate the concentration of the gas component included in an exhaust gas emitted from a coal-burning boiler using a neural network, including: a process database section adapted to store process data of a coal-burning boiler; a filtering processing section adapted to perform filtering processing for extracting data suitable for learning of a neural network from the process data stored in the process database section; a neural-network learning processing section adapted to perform learning processing of the neural network based on the data extracted by the filtering processing section and suitable for learning of the neural network; and a neural-network estimation processing section adapted to perform estimation processing of the CO concentration or the NOx concentration in the exhaust gas emitted from the coal-burning boiler based on the learning processing of the neural-network learning processing section.
摘要翻译： 一种燃煤锅炉的气体浓度估计装置，其适用于使用神经网络来估计从燃煤锅炉排出的排气中所含的气体成分的浓度，所述气体成分估算装置包括：处理数据库部，其适于存储 燃煤锅炉; 滤波处理部，其适于进行从存储在所述处理数据库部中的处理数据中提取适于神经网络的学习的数据的滤波处理; 神经网络学习处理部分，适于基于由所述滤波处理部分提取并适合于所述神经网络的学习来执行所述神经网络的学习处理; 以及神经网络估计处理部，其基于神经网络学习处理部的学习处理，对从燃煤锅炉排出的排气中的CO浓度或NOx浓度进行估计处理。
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公开(公告)号：US08413596B2
公开(公告)日：2013-04-09
申请号：US12581724
申请日：2009-10-19
IPC分类号： F23N5/02
CPC分类号： F23C9/003 , F01K13/02 , F22B35/002 , F22B35/18 , F23C2202/30 , F23L7/007 , F23L2900/07001 , F23N1/042 , F23N5/006 , F23N2021/12 , F23N2037/20 , F23N2037/28 , Y02E20/322 , Y02E20/344
摘要： An oxyfuel boiler 1 is equipped with an oxygen separation apparatus 23 to produce oxygen by separating oxygen from the air, a recirculation fan 26 to supply a portion of combustion flue gas branched from the combustion flue gas discharged from the boiler to the oxyfuel boiler 1, a temperature sensor 14a to detect gas temperature at a boiler outlet 1d in the oxyfuel boiler 1, and a control apparatus 150 to calculate gas temperature at a furnace outlet 1c in the boiler from the gas temperature at the boiler outlet 1d detected by the temperature sensor 14a and control the operating condition of the recirculation fan 26 so that the calculated gas temperature at the furnace outlet 1c becomes a desired preset gas temperature.
摘要翻译： 氧燃料锅炉1配备有通过从空气中分离氧而产生氧的氧分离装置23，再循环风扇26，以将从锅炉排出的燃烧烟道气分支的一部分燃烧烟道气供应到氧燃料锅炉1， 用于检测氧燃料锅炉1中的锅炉出口1d处的气体温度的温度传感器14a以及从由温度传感器检测到的锅炉出口1d处的气体温度来计算锅炉中炉出口1c处的气体温度的控制装置150 并且控制再循环风扇26的操作状态，使得炉出口1c处的计算出的气体温度成为期望的预设气体温度。
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公开(公告)号：US08368274B2
公开(公告)日：2013-02-05
申请号：US13122611
申请日：2008-11-10
申请人： Toshiyuki Yoshizawa , Masaya Inoue , Ryuichi Shimomura , Takuma Wada , Kanji Shinkawa , Masao Morita , Yoshiharu Hayashi , Kazuya Nakamachi , Kazunori Tanaka
发明人： Toshiyuki Yoshizawa , Masaya Inoue , Ryuichi Shimomura , Takuma Wada , Kanji Shinkawa , Masao Morita , Yoshiharu Hayashi , Kazuya Nakamachi , Kazunori Tanaka
CPC分类号： H02K21/044
摘要： Dynamoelectric machine having holding grooves recessed into yoke portions with openings on respective facing portions of inner wall surfaces of trough portions, at axially inner ends of the yoke portions, having axial groove directions, and an end surface in a groove length direction constitutes a stopping surface. Magnet material holders are disposed spanning the trough portions radially inside inner circumferential surfaces near tip ends of claw-shaped magnetic pole portions, fitted from axially inside into each holding groove, are recessed to face each other on the trough portions restricting circumferential and radial motion by inner wall surfaces of the holding grooves and axially outward movement restricted by the stopping surface. Interfitting grooves having openings on surfaces facing the inner circumferential surfaces near the tip ends, having axial groove directions, and passing through in the axial direction, and permanent magnets fitted into the interfitting grooves are held by the magnet material holders.
摘要翻译： 具有凹槽的保持槽的凹槽中具有凹槽的保持槽，在槽部的内壁面的相对的相对部分上具有凹口的轭部，在轭部的轴向内端具有轴向槽方向，并且槽长度方向上的端面构成止动表面 。 磁性材料保持器跨越槽部，从爪状磁极部的端部附近的内周面径向地配置，从轴向内侧配合到各保持槽中，在槽部上凹陷，从而通过限制周向和径向运动的槽部 保持槽的内壁表面和由止动表面限制的轴向向外运动。 在具有轴向槽方向并且沿轴向通过的面上与内周面相对的表面上具有开口的相互配合槽，并且配合在配合槽中的永久磁铁被磁体保持件保持。
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公开(公告)号：US20070260426A1
公开(公告)日：2007-11-08
申请号：US11826619
申请日：2007-07-17
申请人： Yoshiharu Hayashi
发明人： Yoshiharu Hayashi
IPC分类号： G06F15/00
摘要： One of the thermal transmission rates that represent thermal transmission from gas to steam in a heat exchanger constituting a boiler is calculated based on thermal conductivity rate of pipes and thermal transfer of steam and gas, and the other is compared with the thermal conductivity rate calculated based on the thermal conductivity rate of the pipes and thermal transfer rate of steam and gas.
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公开(公告)号：US20070203862A1
公开(公告)日：2007-08-30
申请号：US11624416
申请日：2007-01-18
申请人： Takaaki Sekiai , Satoru Shimizu , Eiichi Kaminaga , Akihiro Yamada , Yoshiharu Hayashi , Naohiro Kusumi , Masayuki Fukai
发明人： Takaaki Sekiai , Satoru Shimizu , Eiichi Kaminaga , Akihiro Yamada , Yoshiharu Hayashi , Naohiro Kusumi , Masayuki Fukai
CPC分类号： G05B13/048
摘要： There is provided a control apparatus including a function of generating an operation signal applied to a control subject and a model that simulates characteristics of the control subject, a function of receiving an evaluation value signal calculated based on a measurement signal obtained by applying the operation signal to the control subject and the model, and a function of learning to generate the operation signal such that an expected value of the sum of the evaluation value signals obtained from a present state to a future state is either maximum or minimum in which the evaluation value signal calculated based on the measurement signal from the model is calculated by adding a first evaluation value obtained based on a deviation between the measurement signal obtained from the model and a setpoint value, and a second evaluation value obtained based on a difference in characteristics between the model and the control subject.
摘要翻译： 提供了一种控制装置，包括产生施加到控制对象的操作信号和模拟控制对象的特性的模型的功能，接收基于通过应用操作信号而获得的测量信号计算的评估值信号的功能 控制主体和模型的功能，以及学习生成操作信号的功能，使得从当前状态到未来状态获得的评估值信号的和的期望值是最大值或最小值，其中评估值 通过添加基于从模型获得的测量信号与设定值之间的偏差获得的第一评估值和基于来自模型的特性差异获得的第二评估值来计算基于来自模型的测量信号计算的信号 模型和控制科目。
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9.发明申请Generated steam estimation method and device for heat recovery steam generator, and maintenance planning support method and system for power generation facility 有权用于热回收蒸汽发生器的生成蒸汽估计方法和装置，以及发电设备的维护计划支持方法和系统公开(公告)号：US20060200325A1
公开(公告)日：2006-09-07
申请号：US11331219
申请日：2006-01-13
申请人： Yoshiharu Hayashi
发明人： Yoshiharu Hayashi
IPC分类号： G06F17/10
摘要： A method for configuring the physical model of a heat recovery steam generator that can estimate the state quantity of generated steam from the state quantity of the exhaust gas to be introduced, and capable of establishing the physical model of a combined cycle power generation facility thereby. The optimum values for the flow rates Flp and Fhp, pressures and temperatures Tlp and Thp of the low pressure main steam and high pressure main steam are computed in such a way as to ensure that an objective function E stored in advance will come close to zero.
摘要翻译： 一种用于配置热回收蒸汽发生器的物理模型的方法，所述热回收蒸汽发生器可以从待引入的排气的状态量估计产生的蒸汽的状态量，并且能够建立由此产生的联合循环发电设备的物理模型。 计算低压主蒸汽和高压主蒸汽的流量Flp和Fhp，压力和温度Tlp和Thp的最佳值，以确保预先存储的目标函数E将接近零 。
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公开(公告)号：US20060148875A1
公开(公告)日：2006-07-06
申请号：US11363202
申请日：2006-02-28
申请人： Yoshiharu Hayashi , Nobuharu Goto
发明人： Yoshiharu Hayashi , Nobuharu Goto
IPC分类号： A61K31/4164
CPC分类号： C07D233/54 , A61K31/4164 , C07D231/12 , C07D233/56 , C07D249/08
摘要： The present invention relates to an agent for the prophylaxis and treatment of diabetic complications comprising, as an active ingredient, 4-[α-hydroxy-2-methyl-5-(1-imidazolyl)benzyl]-3,5-dimethylbenzoic acid, an optically active compound thereof or a pharmaceutically acceptable salt thereof. The present invention further relates to a method for the prophylaxis and treatment of diabetic complications comprising administering an effective amount of this compound. The medicament of the present invention is useful for the prophylaxis and treatment of diabetic complications, namely, diabetic neuropathy, nephropathy, ophthalmopathy, arteriosclerosis and the like. The action of the drug is long-lasting for very small doses and a single administration a day is sufficient.
摘要翻译： 本发明涉及用于预防和治疗糖尿病并发症的药剂，其包含作为活性成分的4- [α-羟基-2-甲基-5-（1-咪唑基）苄基] -3,5-二甲基苯甲酸， 其光学活性化合物或其药学上可接受的盐。 本发明还涉及预防和治疗糖尿病并发症的方法，包括给予有效量的该化合物。 本发明的药物可用于预防和治疗糖尿病并发症，即糖尿病性神经病，肾病，眼病，动脉硬化等。 药物的作用对于非常小的剂量是持久的，每天一次给药是足够的。
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