摘要:
The present invention relates to calcium bis[(2S)-3-[3-[(2S)-3-(4-chloro-2-cyanophenoxy) -2-fluoropropoxy]phenyl]-2-isopropoxypropionate] represented by formula (I), a hydrate thereof, a crystal of the compound of formula (I), and a crystal of the hydrate of the compound of formula (I) which are useful as pharmaceuticals, and to processes for producing the same, and intermediates therefore, and processes for production thereof.There is need for (2S)-3-[3-[(2S)-3-(4 -chloro-2-cyanophenoxy)-2-fluoropropoxy]phenyl]-2-isopropoxypropionic acid, in the form of a drug substance, purified so as to minimize a residual solvent content and having a uniformized specification and a highly favorable workability, and a process for producing the same.Crystalline calcium bis[(2S)-3-[3-[(2S)-3-(4 -chloro-2-cyanophenoxy)-2-fluoropropoxy]phenyl]-2-isopropoxypropionate], a calcium salt of (2S) -3-[3-[(2S)-3-(4-chloro-2-cyanophenoxy)-2-fluoropropoxy]phenyl]-2-isopropoxypropionic acid, solves the above problem.
摘要:
The present invention relates to calcium bis[(2S)-3-[3-[(2S)-3-(4-chloro-2-cyanophenoxy)-2-fluoropropoxy]phenyl]-2-isopropoxypropionate] represented by formula (I), a hydrate thereof, a crystal of the compound of formula (I), and a crystal of the hydrate of the compound of formula (I) which are useful as pharmaceuticals, and to processes for producing the same, and intermediates therefore, and processes for production thereof.[Problem] There is need for (2S)-3-[3-[(2S)-3-(4-chloro-2-cyanophenoxy)-2-fluoropropoxy]phenyl]-2-isopropoxypropionic acid, in the form of a drug substance, purified so as to minimize a residual solvent content and having a uniformized specification and a highly favorable workability, and a process for producing the same. [Solution] Crystalline calcium bis[(2S)-3-[3-[(2S)-3-(4-chloro-2-cyanophenoxy)-2-fluoropropoxy]phenyl]-2-isopropoxypropionate], a calcium salt of (2S)-3-[3-[(2S)-3-(4-chloro-2-cyanophenoxy)-2-fluoropropoxy]phenyl]-2-isopropoxypropionic acid, solves the above problem. [Selected Drawing] None
摘要:
The present invention relates to calcium bis[(2S)-3-[3-[(2S)-3-(4-chloro-2-cyanophenoxy)-2-fluoropropoxy]phenyl]-2-isopropoxypropionate] represented by formula (I), a hydrate thereof, a crystal of the compound of formula (I), and a crystal of the hydrate of the compound of formula (I) which are useful as pharmaceuticals, and to processes for producing the same, and intermediates therefore, and processes for production thereof. [Problem]There is need for (2S)-3-[3-[(2S)-3-(4-chloro-2-cyanophenoxy)-2-fluoropropoxy]phenyl]-2-isopropoxypropionic acid, in the form of a drug substance, purified so as to minimize a residual solvent content and having a uniformized specification and a highly favorable workability, and a process for producing the same. [Solution]Crystalline calcium bis[(2S)-3-[3-[(2S)-3-(4-chloro-2-cyanophenoxy)-2-fluoropropoxy]phenyl]-2-isopropoxypropionate], a calcium salt of (2S)-3-[3-[(2S)-3-(4-chloro-2-cyanophenoxy)-2-fluoropropoxy]phenyl]-2-isopropoxypropionic acid, solves the above problem. [Selected Drawing] None
摘要:
A gas turbine combustor is provided with a combustor basket where combustion gas flows, the combustion gas being produced by combustion of fuel injected from a nozzle, and a first resonance device and a second resonance device mounted on an outer surface of the combustor basket. The second resonance device is disposed on a downstream side from the first resonance device in a flow of the combustion gas and damps combustion oscillation of a frequency higher than the first resonance device. The first and second resonance devices are acoustic liners each having a housing mounted to the outer surface of the combustor basket. A resonance space surrounded by the housing and the outer surface of the combustor basket communicates with an interior space of the combustor basket via a plurality of acoustic holes formed in the combustor basket.
摘要:
In a gas-turbine combustion burner which is provided, at a distal end thereof, with a fuel spraying hole that sprays fuel into a combustion region formed inside a combustion cylinder of a gas-turbine combustor and in which a fuel flow path that guides the fuel, which is supplied from a fuel source, to the fuel spraying hole is formed in the interior thereof, the impedance of a fuel supply system that guides the fuel from the fuel source to the fuel spraying hole is set so that propagation of pressure fluctuations from the combustion region to the fuel supply system becomes an allowable level or less.
摘要:
An object is to provide a combustor that requires a small mounting space for an acoustic damper, that can achieve size reduction, and that can improve the ease of maintenance. A combustor (5) of the present invention includes a combustion cylinder (19) that defines a combustion area (23) therein and an acoustic damper (31) that has a damper cover having an acoustic-damper resonance space communicating with the combustion area (23). The damper cover is provided along the combustion cylinder (19) so as to extend in a direction intersecting an axial direction (L) of the combustion cylinder (19).
摘要:
In a gas turbine that generates rotational power by supplying fuel to compressed air compressed by a compressor and burning the fuel in a combustor and supplying resultant combustion gas to a turbine, a circumferential distance starting from a leading edge of a turbine first stage nozzle toward a trailing edge side of the first stage nozzle and ending at center of transition pieces of such combustors that are adjacent in a circumferential direction is set relative to a circumferential pitch of such first stage nozzles within a range of 0.05≦S/P≦0.15, and an axial distance between a leading edge of the first stage nozzle and a transition piece rear end of the combustor is set relative to the circumferential pitch of the first stage nozzles within a range of 0.00≦L/P≦0.13. By improving the relative position of a transition piece of the combustor and the first stage nozzle, both suppression of inner pressure fluctuations of the combustor and enhancement in aerodynamic efficiency can be achieved.
摘要翻译:在燃气轮机中,通过向由压缩机压缩的压缩空气供给燃料并燃烧燃烧器中的燃料并将合成的燃烧气体供给到涡轮机而产生旋转动力,从涡轮机第一级喷嘴的前缘朝向 第一级喷嘴的后缘侧并且在这样的燃烧器的周向相邻的过渡件的中心处终止,相对于这种第一级喷嘴的周向间距设定在0.05< NlE; S / P≦̸ 0.15的范围内, 并且在第一级喷嘴的前缘与燃烧器的过渡件后端之间的轴向距离相对于第一级喷嘴的周向间距设定在0.00& llE; L / P≦̸ 0.13的范围内。 通过改善燃烧器和第一级喷嘴的过渡件的相对位置,可以实现燃烧器的内部压力波动的抑制和空气动力学效率的提高。
摘要:
A gas turbine including a combustion oscillation suppressing device disposed to a transition piece of a combustor to define a gas space S, and having a plurality of vent holes through which a gas space L and the inside of the transition piece communicate. The combustion oscillation suppressing device is formed of a first member and a second member which define the gas space, the second member having the plurality of vent holes, and a portion of a transition piece wall includes the second member. A distance from the second member to the first member in the radial direction of the transition piece is a height of the gas space, and when the height of the gas space varies along an axial direction of the transition piece, an opening ratio σp of each of the plurality of vent holes is adjusted depending on the height of the gas space.
摘要:
A gas turbine combustor is provided with a combustor basket where combustion gas flows, the combustion gas being produced by combustion of fuel injected from a nozzle, and a first resonance device and a second resonance device mounted on an outer surface of the combustor basket. The second resonance device is disposed on a downstream side from the first resonance device in a flow of the combustion gas and damps combustion oscillation of a frequency higher than the first resonance device. The first and second resonance devices are acoustic liners each having a housing mounted to the outer surface of the combustor basket. A resonance space surrounded by the housing and the outer surface of the combustor basket communicates with an interior space of the combustor basket via a plurality of acoustic holes formed in the combustor basket.
摘要:
An object of the present invention is to provide a gas turbine that improves appearance of a combustion oscillation suppressing device disposed to a transition piece of a combustor. To achieve the object, a combustion oscillation suppressing device 34 is disposed to a transition piece 32 of a combustor to define a gas space S, and has a plurality of vent holes 343 through which a gas space L and the inside of the transition piece 32 communicate with each other. The combustion oscillation suppressing device 34 has: a first member 341 that has a substantially U-shaped cross-section formed by press-working, and is disposed on the outer circumference of the transition piece 32 with a substantially U-shaped cross-section opening thereof facing the transition piece 32; and a second member 342 that defines the gas space S between the first member 341 and the second member 342 by blocking the substantially U-shaped cross-section opening of the first member 341, and has the vent holes 343. In a radial-direction cross section of the transition piece 32, when the outer diameter of the transition piece 32 varies along an axial direction of the transition piece 32, distances d1 and d2 from the axis L of the transition piece 32 to each bent portion of the first member 341 having a substantially U-shaped cross-section are set to be substantially equal.