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公开(公告)号：US20170146554A1
公开(公告)日：2017-05-25
申请号：US15401698
申请日：2017-01-09
发明人： Masanori HARA , Akihiko SAITO , Yasuhiko TOMINO , Katsuhiko ASANUMA , Hiroyuki KUROSAWA , Shinya OGASAWARA , Yoshiaki HIRAYAMA
IPC分类号： G01N33/68 , A61K31/549 , A61K38/28
CPC分类号： G01N33/6893 , A61K31/401 , A61K31/404 , A61K31/41 , A61K31/4178 , A61K31/4184 , A61K31/4245 , A61K31/4422 , A61K31/549 , A61K31/55 , A61K31/551 , A61K31/554 , A61K38/28 , G01N2333/70596 , G01N2800/042 , G01N2800/347 , G01N2800/56 , A61K2300/00
摘要： Provided is a test method for the detection of diabetic nephropathy at an early stage as compared to a conventional method. Specifically provided are: a test method for diabetic nephropathy, including detecting urinary podocalyxin; the test method, further including assessing diabetic nephropathy at at least Stage I; a test reagent for use in the test method; and a test reagent kit for use in the test method. The present invention is based on a finding that urinary podocalyxin reflects the development and condition of diabetic nephropathy with high sensitivity at an early stage as compared to urinary albumin.
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公开(公告)号：US20170146553A1
公开(公告)日：2017-05-25
申请号：US15401652
申请日：2017-01-09
发明人： Masanori HARA , Akihiko SAITO , Yasuhiko TOMINO , Katsuhiko ASANUMA , Hiroyuki KUROSAWA , Shinya OGASAWARA , Yoshiaki HIRAYAMA
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , A61K31/401 , A61K31/55 , G01N2800/347 , A61K2300/00
摘要： Provided is a test method for the assessment of the necessity of renal biopsy in a subject to be tested, who is suspected of having a renal disease. Specifically provided are a test method for a renal disease, including using urinary podocalyxin and one or more additional markers in combination, and a test reagent for use in the test method and a test reagent kit for use in the test method. The present invention allows the discrimination of a poor prognosis group even for poor prognosis cases with no overt findings in a conventional test method, and thus allows the assessment of a renal disease, the assessment of the necessity of renal biopsy, prognostic prediction, and the like to be performed exactly.
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公开(公告)号：US20160003820A1
公开(公告)日：2016-01-07
申请号：US14748889
申请日：2015-06-24
IPC分类号： G01N33/569
CPC分类号： G01N33/56966 , G01N33/493 , G01N33/6893 , G01N2333/705 , G01N2333/70596 , G01N2800/347
摘要： The present invention relates to a method of detecting urinary podocytes with a light microscope through use of an insoluble carrier-bound antibody that recognizes a protein specifically expressed on a podocyte surface, and more specifically, to a method of detecting urinary podocytes, including the following steps of (1) to (3) : (1) preparing an insoluble carrier-bound antibody by binding an insoluble carrier to an antibody that recognizes a protein specifically expressed on a podocyte surface; (2) bringing a urine sample of a test subject into contact with the insoluble carrier-bound antibody; and (3) observing the urine sample brought into contact with the insoluble carrier-bound antibody with a light microscope to count podocytes.
摘要翻译： 本发明涉及通过使用识别在足细胞表面特异性表达的蛋白质的不溶性载体结合抗体，通过光学显微镜检测尿足细胞的方法，更具体地，涉及检测尿足细胞的方法，包括以下 （1）至（3）的步骤：（1）通过将不溶性载体结合到识别在足细胞表面上特异性表达的蛋白质的抗体来制备不溶性载体结合的抗体; （2）使受检对象的尿液样品与不溶性载体结合的抗体接触; 和（3）用光学显微镜观察与不溶性载体结合的抗体接触的尿液样本以计数足细胞。
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4.发明申请A METHOD FOR ESTIMATING GFR (GLOMERULAR FILTRATION RATE) FROM MEASURED VALUE OF MEGALIN IN URINE 有权用于从尿素中测定的MEGALIN值估算GFR（GLULMULAR FILTRATION RATE）的方法公开(公告)号：US20160003810A1
公开(公告)日：2016-01-07
申请号：US14768527
申请日：2014-02-19
发明人： Kunihiro YAMAGATA , Akira Hiwatashi , Masahiro HAGIWARA , Hiroyuki KUROSAWA , Yoshiaki HIRAYAMA
IPC分类号： G01N33/53
CPC分类号： G01N33/5308 , G01N33/493 , G01N33/566 , G01N2333/47 , G01N2800/347
摘要： The object of the present invention is to provide a method for estimating the glomerular renal function in a convenient and non-invasive manner. As a result of intensive studies to achieve the above object, the present inventors found that there is a high correlation between the urinary megalin excretion rate and the estimated glomerular filtration rate (eGFR) in renal disease patients, and the glomerular filtration rate (GFR) can be estimated with high probability in a non-invasive manner by measuring the megalin level in the urine. This has led to the completion of the present invention.
摘要翻译： 本发明的目的是提供一种以方便和非侵入性方式估计肾小球肾功能的方法。 作为实现上述目的的深入研究的结果，本发明人发现肾脏疾病患者的尿白蛋白排泄率和估计的肾小球滤过率（eGFR）与肾小球滤过率（GFR）之间存在高度相关性， 可以通过测量尿中的巨蛋白水平以非侵入性的方式高概率地估计。 这导致了本发明的完成。
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