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公开(公告)号：US20080009604A1
公开(公告)日：2008-01-10
申请号：US11878724
申请日：2007-07-26
IPC分类号： C07K1/02
CPC分类号： C07K7/08 , C07K14/001 , C07K14/78
摘要： A peptide component (A) represented by the following formula (1a) with a peptide component (B) represented by the following formula (2a) and a compound (C) represented by the following formula (3a), as an optional component are subjected to a condensation reaction in the presence of a dehydrating and condensing agent and a condensing auxiliary; provided that in the case where “X” represents HOOC—(CH2)m—CO— in the formula (1a) and/or (2a), the reaction is conducted with the compound (C). The ratio of the peptide component (A) relative to the peptide component (B) is 100/0 to 30/70 (mol %), and the ratio of the compound (C) relative to the total molar amount of the peptide component (A) and/or the peptide component (B). X-(Pro-Y-Gly)n-OH (1a), X—(Z)r—OH (2a), H2N—R—NH2 (3a) Wherein “X” represents H or the group HOOC—(CH2)m—CO— (“m”=1 to 18), “Y” represents Pro or Hyp, “n”=1 to 20, “Z” represents a peptide chain comprising 1 to 10 amino acid residue(s), “r”=1 to 20, and “R” represents a linear or branched alkylene group. The present invention provides a collagenous polypeptide which is free from a risk of an infection by a pathogenic organism (or a causative factor) or an undesirable side effect, and which has a high safety.
摘要翻译： 将由下式（1a）表示的肽成分（B）表示的肽成分（A）和下述式（3a）表示的化合物（C））作为任意成分进行 在脱水缩合剂和冷凝助剂的存在下进行缩合反应; 条件是在“X”表示式（1a）和/或（2a）中的HOOC-（CH 2）m - CO-）的情况下，反应是 与化合物（C）进行反应。 肽成分（A）相对于肽成分（B）的比例为100/0〜30/70（摩尔％），化合物（C）相对于肽成分的总摩尔量 A）和/或肽组分（B）。 X-（Pro-Y-Gly）n -OH（1a），X-（Z）-OH（2a），H 2 其中，“X”表示H或HOOC-（CH 2）m -CO-（“ m“= 1〜18），”Y“表示Pro或Hyp，”n“= 1〜20，”Z“表示包含1〜10个氨基酸残基，”r“= 1〜20， “R”表示直链或支链亚烷基。 本发明提供一种胶原多肽，其不具有致病生物（或致病因子）感染的风险或不期望的副作用，并且具有高安全性。
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公开(公告)号：US07544781B2
公开(公告)日：2009-06-09
申请号：US11878724
申请日：2007-07-26
CPC分类号： C07K7/08 , C07K14/001 , C07K14/78
摘要： A process for producing a polypeptide, by reacting a peptide component (A) represented by formula (1) below with a peptide component (B) represented by formula (2) below and optionally a compound (C) represented by formula (3) below, to obtain said polypeptide: (1) X-(Pro-Y-Gly)n-OH, wherein: X represents H or the group HOOC—(CH2)m—CO— and m denotes an integer of 1 to 18, Y represents Pro or Hyp, and n denotes an integer of 1 to 20; (2) X-(Z)r—OH, wherein X represents H or the group HOOC—(CH2)m—CO— and m denotes an integer of 1 to 18, Z represents a peptide chain comprising 1 to 10 amino acid residue(s), and r denotes an integer of 1 to 20; and (3) H2N—R—NH2, wherein R represents a linear or branched alkylene group; and further wherein the ratio of the peptide component (A) relative to the peptide component (B) is 100/0 to 30/70 (mol %); provided that in the case where X represents the group HOOC—(CH2)m—CO— and m has the same meaning as defined above in formula (1) and/or (2), the amount of compound (C) is substantially 1 mol relative to 1 mol of the total molar amount of peptide component (A) and/or peptide component (B); and in the case where X represents H in the formula (1) and/or (2), the reaction is conducted without compound (C).
摘要翻译： 通过使下述式（1）表示的肽组分（A）与下式（2）表示的肽组分（B）和任选的下述式（3）表示的化合物（C）反应来制备多肽的方法 ，得到所述多肽：（1）X-（Pro-Y-Gly）n -OH，其中：X表示H或HOOC-（CH 2）m -CO-，m表示1〜18的整数，Y 表示Pro或Hyp，n表示1〜20的整数， （2）X-（Z）r-OH，其中X表示H或HOOC-（CH 2）m -CO-基团，m表示1至18的整数，Z表示包含1至10个氨基酸残基的肽链 （s），r表示1〜20的整数， 和（3）H 2 N-R-NH 2，其中R表示直链或支链亚烷基; 并且其中所述肽组分（A）相对于肽组分（B）的比例为100/0至30/70（摩尔％）; 条件是在X表示基团HOOC-（CH 2）m -CO-和m具有与上述式（1）和/或（2）中所定义相同的含义的情况下，化合物（C）的量基本上为1 相对于肽组分（A）和/或肽组分（B）的总摩尔量的1mol; 在式（1）和/或（2）中X表示H的情况下，反应不进行化合物（C）。
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3.发明申请Synthetic polypeptide-containing bioapplicable material and film-forming material 审中-公开含合成多肽的生物应用材料和成膜材料公开(公告)号：US20070207180A1
公开(公告)日：2007-09-06
申请号：US11365832
申请日：2006-03-02
CPC分类号： A61K38/16 , C07K5/0823
摘要： The present invention provides a bioapplicable material (or composition) or film-forming material (or composition), which is free from a risk of an infection by a pathogenic organism or a transmission of a causative factor, has a high safety. The material (or composition) comprises a collagen-like synthetic polypeptide having at least an amino acid sequence represented by the formula -Pro-Y-Gly- (wherein Y represents Pro or Hyp). The polypeptide may show positive Cotton effect at a wavelength in range of 220 to 230 nm and negative Cotton effect at a wavelength in range of 195 to 205 nm in a circular dichroism spectrum. At least part of the polypeptide may be capable of forming a triple helical structure. The polypeptide may be degradable with a collagenase.
摘要翻译： 本发明提供了一种生物应用材料（或组合物）或成膜材料（或组合物），其不具有病原体感染或致病因子的传播的风险，具有高安全性。 材料（或组合物）包含至少具有由式-Pro-Y-Gly-（其中Y表示Pro或Hyp）表示的氨基酸序列的胶原样合成多肽。 多肽可以在波长为220-230nm的范围内显示出正的棉花效应，在圆二色谱中在195至205nm的波长范围内显示出负的棉花效应。 多肽的至少一部分可能能够形成三重螺旋结构。 多肽可以用胶原酶降解。
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公开(公告)号：US07262275B2
公开(公告)日：2007-08-28
申请号：US10372994
申请日：2003-02-26
CPC分类号： C07K7/08 , C07K14/001 , C07K14/78
摘要： The invention provides for a polypeptide, which is useful as a biomaterial and free from infection. The polypeptide comprises a peptide unit of formula (1), and optionally one or more units of formulae (2) to (3): (1) [—(OC—(CH2)m—CO)p-(Pro-Y-Gly)n-]a; (2) [—(OC—(CH2)m—CO)q-(Z)r-]b; and (3) [—HN—R—NH—]c, wherein “m” is 1-18 , “p” and “q” are identical or different, and each is 0 or 1 , “Y” is Pro or Hyp, and “n”1-20 ; “Z” is a peptide chain comprising 1-10 amino acids, “r”1-20 , and “R” is a linear or branched alkylene group; the molar ratio of “a” to “b”[a/b] is 100/0 to 30/70 ; when p=1 and q=0, c=a, when p=0 and q=1, c=b, when p=1 and q=1, c=a+b, and when p=0 and q=0, c=0; and the polypeptide shows a peak of molecular weight in a range from 1×104 to 100×104 in the molecular weight distribution.
摘要翻译： 本发明提供了可用作生物材料并且不感染的多肽。 多肽包含式（1）的肽单元和任选的一个或多个式（2）至（3）的单元：（1）[ - （OC-（CH 2） m-CO）p - （Pro-Y-Gly）n - - - - - - - - （2）[ - （OC-（CH 2）m -CO）q - （Z） - ] 和（3）[-HN-R-NH-] C，其中“m”为1-18，“p”和“q”相同或不同，并且各自为0或1， “Y”是Pro或Hyp，“n”1-20; “Z”是包含1-10个氨基酸“r”1-20的肽链，“R”是直链或支链亚烷基; “a”与“b”[a / b]的摩尔比为100/0至30/70; 当p = 1和q = 0时，c = a，当p = 0和q = 1时，c = b，当p = 1和q = 1时，c = a + b，当p = 0且q = 0时 ，c = 0; 并且多肽在分子量分布中显示分子量在1×10 4至100×10 4范围内的峰。
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