公开(公告)号：US20080009604A1

公开(公告)日：2008-01-10

申请号：US11878724

申请日：2007-07-26

申请人： Masao Tanihara ,  Chikara Otsuki ,  Hiroshi Mikami ,  Hisao Kinoshita

发明人： Masao Tanihara ,  Chikara Otsuki ,  Hiroshi Mikami ,  Hisao Kinoshita

IPC分类号： C07K1/02

CPC分类号： C07K7/08 ,  C07K14/001 ,  C07K14/78

摘要： A peptide component (A) represented by the following formula (1a) with a peptide component (B) represented by the following formula (2a) and a compound (C) represented by the following formula (3a), as an optional component are subjected to a condensation reaction in the presence of a dehydrating and condensing agent and a condensing auxiliary; provided that in the case where “X” represents HOOC—(CH2)m—CO— in the formula (1a) and/or (2a), the reaction is conducted with the compound (C). The ratio of the peptide component (A) relative to the peptide component (B) is 100/0 to 30/70 (mol %), and the ratio of the compound (C) relative to the total molar amount of the peptide component (A) and/or the peptide component (B). X-(Pro-Y-Gly)n-OH (1a), X—(Z)r—OH (2a), H2N—R—NH2 (3a) Wherein “X” represents H or the group HOOC—(CH2)m—CO— (“m”=1 to 18), “Y” represents Pro or Hyp, “n”=1 to 20, “Z” represents a peptide chain comprising 1 to 10 amino acid residue(s), “r”=1 to 20, and “R” represents a linear or branched alkylene group. The present invention provides a collagenous polypeptide which is free from a risk of an infection by a pathogenic organism (or a causative factor) or an undesirable side effect, and which has a high safety.

摘要翻译： 将由下式（1a）表示的肽成分（B）表示的肽成分（A）和下述式（3a）表示的化合物（C））作为任意成分进行 在脱水缩合剂和冷凝助剂的存在下进行缩合反应; 条件是在“X”表示式（1a）和/或（2a）中的HOOC-（CH 2）m - CO-）的情况下，反应是 与化合物（C）进行反应。 肽成分（A）相对于肽成分（B）的比例为100/0〜30/70（摩尔％），化合物（C）相对于肽成分的总摩尔量 A）和/或肽组分（B）。 X-（Pro-Y-Gly）n -OH（1a），X-（Z）-OH（2a），H 2 其中，“X”表示H或HOOC-（CH 2）m -CO-（“ m“= 1〜18），”Y“表示Pro或Hyp，”n“= 1〜20，”Z“表示包含1〜10个氨基酸残基，”r“= 1〜20， “R”表示直链或支链亚烷基。 本发明提供一种胶原多肽，其不具有致病生物（或致病因子）感染的风险或不期望的副作用，并且具有高安全性。

公开(公告)号：US20070207180A1

公开(公告)日：2007-09-06

申请号：US11365832

申请日：2006-03-02

申请人： Masao Tanihara ,  Chikara Otsuki ,  Hiroshi Mikami ,  Hisao Kinoshita

发明人： Masao Tanihara ,  Chikara Otsuki ,  Hiroshi Mikami ,  Hisao Kinoshita

IPC分类号： A61K38/16 ,  C07K7/08 ,  C07K7/06

CPC分类号： A61K38/16 ,  C07K5/0823

摘要： The present invention provides a bioapplicable material (or composition) or film-forming material (or composition), which is free from a risk of an infection by a pathogenic organism or a transmission of a causative factor, has a high safety. The material (or composition) comprises a collagen-like synthetic polypeptide having at least an amino acid sequence represented by the formula -Pro-Y-Gly- (wherein Y represents Pro or Hyp). The polypeptide may show positive Cotton effect at a wavelength in range of 220 to 230 nm and negative Cotton effect at a wavelength in range of 195 to 205 nm in a circular dichroism spectrum. At least part of the polypeptide may be capable of forming a triple helical structure. The polypeptide may be degradable with a collagenase.

摘要翻译： 本发明提供了一种生物应用材料（或组合物）或成膜材料（或组合物），其不具有病原体感染或致病因子的传播的风险，具有高安全性。 材料（或组合物）包含至少具有由式-Pro-Y-Gly-（其中Y表示Pro或Hyp）表示的氨基酸序列的胶原样合成多肽。 多肽可以在波长为220-230nm的范围内显示出正的棉花效应，在圆二色谱中在195至205nm的波长范围内显示出负的棉花效应。 多肽的至少一部分可能能够形成三重螺旋结构。 多肽可以用胶原酶降解。

公开(公告)号：US07262275B2

公开(公告)日：2007-08-28

申请号：US10372994

申请日：2003-02-26

申请人： Masao Tanihara ,  Chikara Otsuki ,  Hiroshi Mikami ,  Hisao Kinoshita

发明人： Masao Tanihara ,  Chikara Otsuki ,  Hiroshi Mikami ,  Hisao Kinoshita

IPC分类号： A61K38/17 ,  A61K38/00 ,  C07K16/00

CPC分类号： C07K7/08 ,  C07K14/001 ,  C07K14/78

摘要： The invention provides for a polypeptide, which is useful as a biomaterial and free from infection. The polypeptide comprises a peptide unit of formula (1), and optionally one or more units of formulae (2) to (3): (1) [—(OC—(CH2)m—CO)p-(Pro-Y-Gly)n-]a; (2) [—(OC—(CH2)m—CO)q-(Z)r-]b; and (3) [—HN—R—NH—]c, wherein “m” is 1-18 , “p” and “q” are identical or different, and each is 0 or 1 , “Y” is Pro or Hyp, and “n”1-20 ; “Z” is a peptide chain comprising 1-10 amino acids, “r”1-20 , and “R” is a linear or branched alkylene group; the molar ratio of “a” to “b”[a/b] is 100/0 to 30/70 ; when p=1 and q=0, c=a, when p=0 and q=1, c=b, when p=1 and q=1, c=a+b, and when p=0 and q=0, c=0; and the polypeptide shows a peak of molecular weight in a range from 1×104 to 100×104 in the molecular weight distribution.

摘要翻译： 本发明提供了可用作生物材料并且不感染的多肽。 多肽包含式（1）的肽单元和任选的一个或多个式（2）至（3）的单元：（1）[ - （OC-（CH 2） m-CO）p - （Pro-Y-Gly）n - - - - - - - - （2）[ - （OC-（CH 2）m -CO）q - （Z） - ] 和（3）[-HN-R-NH-] C，其中“m”为1-18，“p”和“q”相同或不同，并且各自为0或1， “Y”是Pro或Hyp，“n”1-20; “Z”是包含1-10个氨基酸“r”1-20的肽链，“R”是直链或支链亚烷基; “a”与“b”[a / b]的摩尔比为100/0至30/70; 当p = 1和q = 0时，c = a，当p = 0和q = 1时，c = b，当p = 1和q = 1时，c = a + b，当p = 0且q = 0时 ，c = 0; 并且多肽在分子量分布中显示分子量在1×10 4至1​​00×10 4范围内的峰。

公开(公告)号：US07544781B2

公开(公告)日：2009-06-09

申请号：US11878724

申请日：2007-07-26

申请人： Masao Tanihara ,  Chikara Otsuki ,  Hiroshi Mikami ,  Hisao Kinoshita

发明人： Masao Tanihara ,  Chikara Otsuki ,  Hiroshi Mikami ,  Hisao Kinoshita

IPC分类号： A61K38/17 ,  A61K38/00 ,  C07K16/00

CPC分类号： C07K7/08 ,  C07K14/001 ,  C07K14/78

摘要： A process for producing a polypeptide, by reacting a peptide component (A) represented by formula (1) below with a peptide component (B) represented by formula (2) below and optionally a compound (C) represented by formula (3) below, to obtain said polypeptide: (1) X-(Pro-Y-Gly)n-OH, wherein: X represents H or the group HOOC—(CH2)m—CO— and m denotes an integer of 1 to 18, Y represents Pro or Hyp, and n denotes an integer of 1 to 20; (2) X-(Z)r—OH, wherein X represents H or the group HOOC—(CH2)m—CO— and m denotes an integer of 1 to 18, Z represents a peptide chain comprising 1 to 10 amino acid residue(s), and r denotes an integer of 1 to 20; and (3) H2N—R—NH2, wherein R represents a linear or branched alkylene group; and further wherein the ratio of the peptide component (A) relative to the peptide component (B) is 100/0 to 30/70 (mol %); provided that in the case where X represents the group HOOC—(CH2)m—CO— and m has the same meaning as defined above in formula (1) and/or (2), the amount of compound (C) is substantially 1 mol relative to 1 mol of the total molar amount of peptide component (A) and/or peptide component (B); and in the case where X represents H in the formula (1) and/or (2), the reaction is conducted without compound (C).

摘要翻译： 通过使下述式（1）表示的肽组分（A）与下式（2）表示的肽组分（B）和任选的下述式（3）表示的化合物（C）反应来制备多肽的方法 ，得到所述多肽：（1）X-（Pro-Y-Gly）n -OH，其中：X表示H或HOOC-（CH 2）m -CO-，m表示1〜18的整数，Y 表示Pro或Hyp，n表示1〜20的整数， （2）X-（Z）r-OH，其中X表示H或HOOC-（CH 2）m -CO-基团，m表示1至18的整数，Z表示包含1至10个氨基酸残基的肽链 （s），r表示1〜20的整数， 和（3）H 2 N-R-NH 2，其中R表示直链或支链亚烷基; 并且其中所述肽组分（A）相对于肽组分（B）的比例为100/0至30/70（摩尔％）; 条件是在X表示基团HOOC-（CH 2）m -CO-和m具有与上述式（1）和/或（2）中所定义相同的含义的情况下，化合物（C）的量基本上为1 相对于肽组分（A）和/或肽组分（B）的总摩尔量的1mol; 在式（1）和/或（2）中X表示H的情况下，反应不进行化合物（C）。

公开(公告)号：US08299273B2

公开(公告)日：2012-10-30

申请号：US12855597

申请日：2010-08-12

申请人： Hiroshi Mikami ,  Makoto Nitta ,  Naoki Noguchi

发明人： Hiroshi Mikami ,  Makoto Nitta ,  Naoki Noguchi

IPC分类号： C07D307/89

CPC分类号： C08G73/1007 ,  C07D307/89 ,  C08G73/10

摘要： To provide a process for producing BPDA whereby high productivity is attained while high purity is maintained.A process for producing biphenyltetracarboxylic acid dianhydride, which comprises heating biphenyltetracarboxylic acid to produce biphenyltetracarboxylic acid dianhydride, characterized in that the heating is carried out at a pressure of from 1×102 Pa to 1.1×105 Pa to a maximum temperature in a range of from 210° C. to 250° C. in such a manner that the temperature rising rate is higher than 50° C./hr for a period of at least ¼ of the time for the temperature rise from 60° C. to 210° C., and the temperature is maintained to be from 150° C. to 250° C. for from 0.5 to 10 hours.

摘要翻译： 提供一种生产BPDA的方法，从而在保持高纯度的同时获得高生产率。 制备联苯四羧酸二酐的方法，其包括加热联苯四羧酸以制备联苯四羧酸二酐，其特征在于，在1×102Pa至1.1×10 5 Pa的压力下进行加热至最高温度范围为 210℃至250℃，温度升高速率高于50℃/小时，至少为温度从60℃升至210℃的时间的1/4 并且将温度保持在150℃至250℃下0.5至10小时。

公开(公告)号：US08252061B2

公开(公告)日：2012-08-28

申请号：US12084265

申请日：2006-10-26

申请人： Hiroshi Mikami ,  Sumihiko Maeno

发明人： Hiroshi Mikami ,  Sumihiko Maeno

IPC分类号： A61F2/32

CPC分类号： A61F2/30739 ,  A61F2/32 ,  A61F2/34 ,  A61F2/36 ,  A61F2/367 ,  A61F2/3676 ,  A61F2002/30332 ,  A61F2002/30354 ,  A61F2002/30462 ,  A61F2002/30469 ,  A61F2002/30471 ,  A61F2002/30474 ,  A61F2002/30492 ,  A61F2002/30507 ,  A61F2002/30538 ,  A61F2002/30578 ,  A61F2002/30599 ,  A61F2002/30604 ,  A61F2002/30626 ,  A61F2002/30784 ,  A61F2002/3625 ,  A61F2002/3627 ,  A61F2002/3631 ,  A61F2002/365 ,  A61F2002/3674 ,  A61F2220/0025 ,  A61F2220/0033 ,  A61F2220/0075 ,  A61F2220/0091 ,  A61F2250/0006 ,  A61F2250/0063

摘要： A femoral stem including a stem member having a distal part of the stem member which is inserted in a medullary cavity of a femur and fixed therein and a proximal part of the stem member which has a neck for fixing an artificial head and is positioned at a proximal end of the distal part. The distal part and the proximal part are integrated or separable. Also, a plate fixing portion is detachably attached at a top of the proximal part, and a greater trochanter plate is provided for depressing the greater trochanter. The greater trochanter is fixed to the plate fixing portion at a certain angle or is fixed to the plate fixing portion so as to adjust an angle of the trochanter plate.

摘要翻译： 股骨柄，其包括杆部件，所述杆部件具有杆部件的远端部分，其插入在股骨的髓腔中并固定在其中，并且所述杆部件的近端部分具有用于固定人造头部的颈部并且位于 远端部分的近端。 远侧部分和近端部分是一体的或可分离的。 此外，板固定部分可拆卸地附接在近端部分的顶部，并且设置有用于压下大转子的大转子板。 大转子以一定的角度固定在板固定部上，或固定在板固定部上，调整转子板的角度。

公开(公告)号：US07842824B2

公开(公告)日：2010-11-30

申请号：US11570812

申请日：2005-06-28

申请人： Hiroshi Mikami ,  Makoto Nitta ,  Naoki Noguchi

发明人： Hiroshi Mikami ,  Makoto Nitta ,  Naoki Noguchi

IPC分类号： C07D307/89 ,  C08G69/32

CPC分类号： C08G73/1007 ,  C07D307/89 ,  C08G73/10

摘要： To provide a process for producing BPDA whereby high productivity is attained while high purity is maintained.A process for producing biphenyltetracarboxylic acid dianhydride, which comprises heating biphenyltetracarboxylic acid to produce biphenyltetracarboxylic acid dianhydride, characterized in that the heating is carried out at a pressure of from 1×102 Pa to 1.1×105 Pa to a maximum temperature in a range of from 210° C. to 250° C. in such a manner that the temperature rising rate is higher than 50° C./hr for a period of at least ¼ of the time for the temperature rise from 60° C. to 210° C., and the temperature is maintained to be from 150° C. to 250° C. for from 0.5 to 10 hours.

摘要翻译： 提供一种生产BPDA的方法，从而在保持高纯度的同时获得高生产率。 制备联苯四羧酸二酐的方法，其包括加热联苯四羧酸以制备联苯四羧酸二酐，其特征在于，在1×102Pa至1.1×10 5 Pa的压力下进行加热至最高温度范围为 210℃至250℃，温度升高速率高于50℃/小时，至少为温度从60℃升至210℃的时间的1/4 并且将温度保持在150℃至250℃下0.5至10小时。

公开(公告)号：US07459570B2

公开(公告)日：2008-12-02

申请号：US10753881

申请日：2004-01-09

申请人： Hiroshi Mikami ,  Takeshi Sano ,  Makoto Nitta

发明人： Hiroshi Mikami ,  Takeshi Sano ,  Makoto Nitta

IPC分类号： C07D307/00 ,  C07D493/04

CPC分类号： C07C63/331 ,  C07C51/42

摘要： There is provided biphenyltetracarboxylic dianhydride containing biphenyltetracarboxylic monoanhydride in an amount of not more than 0.4%. By using the biphenyltetracarboxylic dianhydride as a raw material, it is possible to produce polyimide or polyamic acid having an increased molecular weight.

公开(公告)号：US20060197503A1

公开(公告)日：2006-09-07

申请号：US10550953

申请日：2004-03-23

申请人： Youichi Arai ,  Hiroshi Mikami

发明人： Youichi Arai ,  Hiroshi Mikami

IPC分类号： H02J7/00

CPC分类号： G01R31/389 ,  G01R31/3648 ,  G01R31/3842 ,  G01R31/392

摘要： A microcomputer 23 monitors a dischargeable capacity corresponding to a value by subtracting a capacity not to be discharged caused by an internal resistance of a battery from a charge capacity of the battery 13 based on outputs of a current sensor 15 and a voltage sensor 17.

摘要翻译： 微型计算机23基于电流传感器15和电压传感器17的输出，从电池13的充电容量中减去由电池的内部电阻引起的不被放电的容量，从而监视对应于该值的放电容量。

公开(公告)号：US3981906A

公开(公告)日：1976-09-21

申请号：US575229

申请日：1975-05-07

申请人： Yohei Fukuoka ,  Toshio Kato ,  Norio Imai ,  Joji Nishikido ,  Masato Hamada ,  Hiroshi Mikami ,  Hirohumi Iwasaki ,  Toshihisa Koike

发明人： Yohei Fukuoka ,  Toshio Kato ,  Norio Imai ,  Joji Nishikido ,  Masato Hamada ,  Hiroshi Mikami ,  Hirohumi Iwasaki ,  Toshihisa Koike

IPC分类号： C07C69/92 ,  C07C69/76

CPC分类号： C07C69/76

摘要： Alkyl 4,4'-(ethylenedioxy)bis-benzoates having improved properties such as anti-oxidation and anti-coloration are prepared in high yield and selectivity by, at the first step, reacting an excess alkyl p-hydroxybenzoate with a recycling alkyl p-(2-chloro-ethoxy)benzoate with heating in the presence of an alkali carbonate and an inert organic solvent until almost said alkyl p-(2-chloroethoxy)benzoate is consumed to produce an alkyl 4,4'-(ethylenedioxy)bis-benzoate and at the second step adding ethylene dichloride to the reaction system and continuing the heating to produce an alkyl p-(2-chloroethoxy)benzoate which is recycled, and separating the alkyl 4,4'-(ethylenedioxy)bis-benzoate produced.

摘要翻译： 通过在第一步骤中，通过使过量的对羟基苯甲酸烷基酯与再循环烷基p反应，以高产率和选择性制备具有改进性能如抗氧化和抗着色的4,4' - （亚乙二氧基）双苯甲酸烷基酯 - （2-氯 - 乙氧基）苯甲酸酯，在碱金属碳酸盐和惰性有机溶剂的存在下加热直到几乎所有的对 - （2-氯乙氧基）苯甲酸烷基酯被消耗以产生4,4' - （亚乙二氧基）双 - 苯甲酸酯，并且在第二步骤中将二氯乙烯加入到反应体系中并继续加热以产生被再循环的对 - （2-氯乙氧基）苯甲酸烷基酯，并分离生成的4,4' - （亚乙二氧基）双苯甲酸烷基酯 。