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    Distillation method of separating organic solvents
    8.
    发明授权
    Distillation method of separating organic solvents 失效
    分离有机溶剂的蒸馏方法

    公开(公告)号：US5275702A

    公开(公告)日：1994-01-04

    申请号：US928298

    申请日：1992-08-12

    申请人： Takehiko Kataoka ,  Haruo Kawasaki ,  Harutoshi Ohura ,  Yoshinobu Uchida ,  Akihiko Yasaki ,  Shinichi Kishimoto

    发明人： Takehiko Kataoka ,  Haruo Kawasaki ,  Harutoshi Ohura ,  Yoshinobu Uchida ,  Akihiko Yasaki ,  Shinichi Kishimoto

    IPC分类号： B01D3/14 ,  B01D3/36 ,  C07B63/00 ,  C07C7/06 ,  C07C15/06 ,  C07C51/46 ,  C07C53/08 ,  C07K5/075

    CPC分类号： C07K5/0613 ,  B01D3/36 ,  C07C51/46

    摘要： The present invention discloses a method to separate each component from a mixed solution of organic solvents obtained during the production of .alpha.-L-aspartyl-L-phenylalanine methyl ester, which is useful as a sweetener, namely, a mixed solution of acetic acid and toluene or a mixed solution of acetic acid, toluene and formic acid, recovering each component with a high recovery ratio with as small number of operations as possible. The method rationalizes the process and is highly valuable in practical use.When each component is separated and recovered from a mixed solution containing acetic acid and toluene as the main components, acetic acid and toluene are separated by azeotropic distillation using water as an azeotropic solvent, and when each component is separated and recovered from a mixed solution containing acetic acid, toluene and formic acid as the main components, (a) the mixed solution is distilled and formic acid is recovered from the top of the column and a mixed solution of acetic acid and toluene is recovered from the bottom of the column; and (b) the mixed solution obtained from the bottom is distilled by using water as an azeotropic solvent and toluene is recovered from the top of the column and acetic acid is recovered from the bottom of the column.

    摘要翻译： 本发明公开了一种将（α）-L-天冬氨酰基-L-苯丙氨酸甲酯制备期间获得的有机溶剂的混合溶液中的每种成分分离的方法，其可用作甜味剂即乙酸混合溶液 酸和甲苯或乙酸，甲苯和甲酸的混合溶液，以尽可能少的操作以高回收率回收每种组分。 该方法使过程合理化，在实际应用中非常有价值。 当从含有乙酸和甲苯作为主要组分的混合溶液中分离和回收各成分时，使用水作为共沸溶剂通过共沸蒸馏分离乙酸和甲苯，并且当将每种组分从含有 乙酸，甲苯和甲酸为主要成分，（a）蒸馏出混合溶液，从塔顶回收甲酸，从塔底回收乙酸和甲苯的混合溶液; 和（b）通过使用水作为共沸溶剂蒸馏从底部获得的混合溶液，并从塔顶回收甲苯，从塔底回收乙酸。

    Method of crystallizing .alpha.-L-aspartyl-L-phenylalanine methyl ester
    9.
    发明授权
    Method of crystallizing .alpha.-L-aspartyl-L-phenylalanine methyl ester 失效
    α-L-天冬氨酰-L-苯丙氨酸甲酯的结晶方法

    公开(公告)号：US5391810A

    公开(公告)日：1995-02-21

    申请号：US121569

    申请日：1993-09-16

    申请人： So Abe ,  Shinichi Kishimoto ,  Toshihisa Kato ,  Hideo Takeda

    发明人： So Abe ,  Shinichi Kishimoto ,  Toshihisa Kato ,  Hideo Takeda

    IPC分类号： C07K5/072 ,  C07K5/075 ,  C07C101/02

    CPC分类号： C07K5/0613

    摘要： In crystallizing .alpha.-APM from a water solution or a mixed solvent solution of water and a lower alcohol in a crystallizer, the pressure in the crystallizer is held at not higher than atmospheric pressure, a water or water/alcohol mixed solution of .alpha.-APM is fed into the crystallizer with stirring so that the solvent is vaporized, and the crystallization solution is cooled and crystallized by the latent heat of vaporization or is heated so as to prevent supercooling.

    摘要翻译： 在结晶器中从水溶液或水和低级醇的混合溶剂溶液中结晶α-APM时，将结晶器中的压力保持在不高于大气压的水溶液或水/乙醇混合的α-APM溶液 在搅拌下进料到结晶器中，使溶剂蒸发，并将结晶溶液冷却并通过蒸发潜热结晶或加热，以防止过冷。