公开(公告)号：US20200237852A1

公开(公告)日：2020-07-30

申请号：US16698513

申请日：2019-11-27

Applicant: Massachusetts Institute of Technology

Inventor： Benjamin Elliott Mead ,  Lauren Levy ,  Daphne Sze ,  Robert Samuel Langer, Jr. ,  Jeffrey Michael Karp ,  Kazuki Hattori ,  Alexander Kann Shalek

IPC: A61K38/06 ,  A61K31/497 ,  A61K31/506 ,  A61K31/366

Abstract: Leucine-rich repeat-containing G-protein coupled receptor 5-positive (LGR5+) intestinal cells are contacted with an inhibitor of exportin 1 (XPO1), thereby producing functionally differentiated intestinal cells. The LGR5+ cells can also be contacted with a Wnt agonist. The LGR5+ cells can also be contacted with a Notch inhibitor.