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公开(公告)号：US20200237852A1
公开(公告)日：2020-07-30
申请号：US16698513
申请日：2019-11-27
Applicant: Massachusetts Institute of Technology
Inventor： Benjamin Elliott Mead , Lauren Levy , Daphne Sze , Robert Samuel Langer, Jr. , Jeffrey Michael Karp , Kazuki Hattori , Alexander Kann Shalek
IPC: A61K38/06 , A61K31/497 , A61K31/506 , A61K31/366
Abstract: Leucine-rich repeat-containing G-protein coupled receptor 5-positive (LGR5+) intestinal cells are contacted with an inhibitor of exportin 1 (XPO1), thereby producing functionally differentiated intestinal cells. The LGR5+ cells can also be contacted with a Wnt agonist. The LGR5+ cells can also be contacted with a Notch inhibitor.
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公开(公告)号：US20170079717A1
公开(公告)日：2017-03-23
申请号：US15310877
申请日：2015-05-13
Applicant: President and Fellows of Harvard College , The Brigham and Women's Hospital , Children's Medical Center Corporation , Massachusetts Institute of Technology
Inventor： Conor J. Walsh , Ellen T. Roche , Panagiotis Polygerinos , Lucia R. Schuster , Jeffrey Michael Karp , Yuhan Lee , Pedro J. del Nido , Assunta Fabozzo , Ingeborg Friehs , Steven Charles Wasserman
CPC classification number: A61B18/24 , A61B17/00491 , A61B17/0057 , A61B17/12113 , A61B17/12122 , A61B17/12131 , A61B2017/00039 , A61B2017/00243 , A61B2017/005 , A61B2017/00575 , A61B2017/00592 , A61B2017/00597 , A61B2017/00601 , A61B2017/0061 , A61B2017/00623 , A61B2017/0065 , A61B2017/00818 , A61B2017/00893 , A61B2017/00907 , A61B2017/12054 , A61B2018/0022 , A61B2018/00285 , A61B2018/00351 , A61B2018/00416 , A61B2018/00494 , A61B2018/00517 , A61B2018/00839 , A61B2018/00982 , A61B2018/2261 , A61B2018/2272 , A61F2/0063 , A61M25/0067
Abstract: An insertable light-dispensing catheter device, comprising a shaft including a proximal and distal end, a light guide extending through the shaft, and a mirror displaceably extendable from the catheter into a position where the mirror receives and reflects light emitted from the light guide. The mirror can be in the form of a coating on an inflatable balloon; and the balloon, when inflated, can press a patch against a defect (e.g., a ventricular septical defect), while the light cures an adhesive that binds the patch to the structure with the defect, thereby remedying the defect.
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3.发明申请公开(公告)号：US20160194604A1
公开(公告)日：2016-07-07
申请号：US14775560
申请日：2014-03-11
Inventor： Jeffrey Michael Karp , Xiaolei Yin , Marc David Succi , Robert Samuel Langer
IPC: C12N5/071
CPC classification number: C12N5/068 , A61K31/19 , A61K31/506 , C12N5/0679 , C12N2501/065 , C12N2501/11 , C12N2501/155 , C12N2501/415 , C12N2501/42 , C12N2501/727 , C12N2501/73 , C12N2513/00
Abstract: Described are cell culture solutions and systems for epithelial stem cell and organoid cultures, formation of epithelial constructs and uses of the same in transplantation. A single layer of epithelial cells that actively self-renews and is organized into crypts and villi clothes the intestine. It has been recently shown that the renewal of intestinal epithelium is driven by Lgr5+ intestinal stem cells (ISC) that reside at the base of these crypts (Barker et al., 2007). Lgr5+ stem cells can be isolated and cultured in vitro to form organoids containing crypt-vcllus structures that recapitulates the native intestinal epithelium (Sato et al., 2009).
Abstract translation: 描述了用于上皮干细胞和有机体培养物的细胞培养物解决方案和系统，上皮构建物的形成及其在移植中的用途。 单层上皮细胞积极自我更新，并被组织成隐窝和绒毛衣服肠。 最近显示，肠上皮的更新由位于这些隐窝基部的Lgr5 +肠干细胞（ISC）驱动（Barker等，2007）。 可以在体外分离和培养Lgr5 +干细胞以形成含有重要天然肠上皮细胞的隐窝结构的有机体（Sato et al。，2009）。
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公开(公告)号：US11021687B2
公开(公告)日：2021-06-01
申请号：US15400877
申请日：2017-01-06
Inventor： Jeffrey Michael Karp , Robert Samuel Langer , Xiaolei Yin
Abstract: A population of enteroendocrine cells (EEC) is obtained from a mammalian post-natal cell population, such as a population including post-natal stem cells, by treating the population with a plurality of small molecules that upregulate ChgA and promote differentiation of the cells to form the enteroendocrine cells. The upregulation of ChgA is such that the fraction of cells expressing CGA in the obtained cell population, as measured by a ChgA Immunostaining Assay, is at least about 1.5%. Small molecules that can be used to differentiate the post-natal cells into the enteroendocrine cells can include at least one of a Wnt activator, a Notch inhibitor, a Wnt inhibitor, a MEK/ERK inhibitor, a growth factor, a HDAC inhibitor, a Histone Methylation Inhibitor, a Tgf-β inhibitor, and a NeuroD1 activator. Also, the insulin expression of a population of mammalian cells is increased by treating the population with a plurality of small molecules that increase the insulin expression.
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公开(公告)号：US10954490B2
公开(公告)日：2021-03-23
申请号：US16028872
申请日：2018-07-06
Inventor： Jeffrey Michael Karp , Xiaolei Yin , Marc David Succi , Robert Samuel Langer
IPC: C12N5/071 , A61K31/19 , A61K31/506
Abstract: Described are cell culture solutions and systems for epithelial stem cell and organoid cultures, formation of epithelial constructs and uses of the same in transplantation.
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Patent Agency Ranking
公开(公告)号：US20190017015A1
公开(公告)日：2019-01-17
申请号：US16028872
申请日：2018-07-06
Inventor： Jeffrey Michael Karp , Xiaolei Yin , Marc David Succi , Robert Samuel Langer
IPC: C12N5/071 , A61K31/506 , A61K31/19
Abstract: Described are cell culture solutions and systems for epithelial stem cell and organoid cultures, formation of epithelial constructs and uses of the same in transplantation.
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公开(公告)号：US10011817B2
公开(公告)日：2018-07-03
申请号：US15394557
申请日：2016-12-29
Applicant: Massachusetts Institute of Technology
Inventor： Rohit Nandkumar Karnik , Seungpyo Hong , Ying Mei , Daniel Griffith Anderson , Jeffrey Michael Karp , Robert S. Langer , Suman Bose
CPC classification number: C12N5/0068 , B01L3/502715 , B01L3/502761 , B01L2200/0647 , B01L2300/0877 , B01L2300/16 , C12M23/16 , C12M47/02 , C12N5/0062 , C12N2501/58 , C12N2501/585 , C12N2533/50 , C12N2533/52 , C12N2535/10
Abstract: The present invention provides systems for cell separation based on cell rolling on surfaces along edges of regions coated with cell adhesion molecules. A variety of designs of coated regions and edges are disclosed.
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公开(公告)号：US11627949B2
公开(公告)日：2023-04-18
申请号：US16782029
申请日：2020-02-04
Applicant: President and Fellows of Harvard College , The Brigham and Women's Hospital , Children's Medical Center Corporation , Massachusetts Institute of Technology
Inventor： Conor J. Walsh , Ellen T. Roche , Panagiotis Polygerinos , Lucia R. Schuster , Jeffrey Michael Karp , Yuhan Lee , Pedro J. del Nido , Assunta Fabozzo , Ingeborg Friehs , Steven Charles Wasserman
Abstract: An insertable catheter device includes a shaft including a proximal end and a distal end, an expandable balloon, and an actuator configured to expand and retract the expandable balloon. The actuator includes a fluid conduit that extends through the shaft and is coupled with the expandable balloon to enable inflation and retraction of the expandable balloon via injection or withdrawal of a fluid to or from the expandable balloon via the fluid conduit. The expandable balloon is displaceably retractable into the shaft and extendable from the shaft. A fluid pump is coupled with the fluid conduit to pump the fluid through the fluid conduit. A patch is positioned to be displaced by the expandable balloon when the expandable balloon is inflated, and the expandable balloon is displaceably retractable into the shaft and displaceably extendable from the shaft.
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公开(公告)号：US10588695B2
公开(公告)日：2020-03-17
申请号：US15310877
申请日：2015-05-13
Applicant: President and Fellows of Harvard College , The Brigham and Women's Hospital , Children's Medical Center Corporation , Massachusetts Institute of Technology
Inventor： Conor J. Walsh , Ellen T. Roche , Panagiotis Polygerinos , Lucia R. Schuster , Jeffrey Michael Karp , Yuhan Lee , Pedro J. del Nido , Assunta Fabozzo , Ingeborg Friehs , Steven Charles Wasserman
Abstract: An insertable light-dispensing catheter device, comprising a shaft including a proximal and distal end, a light guide extending through the shaft, and a mirror displaceably extendable from the catheter into a position where the mirror receives and reflects light emitted from the light guide. The mirror can be in the form of a coating on an inflatable balloon; and the balloon, when inflated, can press a patch against a defect (e.g., a ventricular septical defect), while the light cures an adhesive that binds the patch to the structure with the defect, thereby remedying the defect.
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公开(公告)号：US10041047B2
公开(公告)日：2018-08-07
申请号：US15494291
申请日：2017-04-21
Inventor： Jeffrey Michael Karp , Xiaolei Yin , Marc David Succi , Robert Samuel Langer
IPC: A61K31/19 , A61K31/506 , C12N5/071
CPC classification number: C12N5/068 , A61K31/19 , A61K31/506 , C12N5/0679 , C12N2501/065 , C12N2501/11 , C12N2501/155 , C12N2501/415 , C12N2501/42 , C12N2501/727 , C12N2501/73 , C12N2513/00
Abstract: Described are cell culture solutions and systems for epithelial stem cell and organoid cultures, formation of epithelial constructs and uses of the same in transplantation.
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