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1.
公开(公告)号:US09567642B2
公开(公告)日:2017-02-14
申请号:US14376482
申请日:2013-02-01
Applicant: Massachusetts Institute of Technology
Inventor: David Feldser , Tyler E. Jacks , Leah Marie Schmidt
IPC: A61K39/395 , C12Q1/68 , G01N33/574 , A61K45/06 , C07K16/28
CPC classification number: C12Q1/6886 , A61K39/39558 , A61K45/06 , C07K16/2827 , C12Q2600/106 , G01N33/57484 , G01N2800/52
Abstract: The invention relates to methods and related products for treatment and determining modes of treatment for cancer or prognosis of cancer. Preferably the methods are related to the induction of CD80 in p53 responsive cancer cells.
Abstract translation: 本发明涉及用于治疗和确定癌症治疗方式或癌症预后的方法和相关产品。 优选地,所述方法与p53反应性癌细胞中CD80的诱导有关。
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公开(公告)号:US20150218645A1
公开(公告)日:2015-08-06
申请号:US14376482
申请日:2013-02-01
Applicant: Massachusetts Institute of Technology
Inventor: David Feldser , Tyler E. Jacks , Leah Marie Schmidt
IPC: C12Q1/68 , A61K45/06 , A61K39/395 , C07K16/28
CPC classification number: C12Q1/6886 , A61K39/39558 , A61K45/06 , C07K16/2827 , C12Q2600/106 , G01N33/57484 , G01N2800/52
Abstract: The invention relates to methods and related products for treatment and determining modes of treatment for cancer or prognosis of cancer. Preferably the methods are related to the induction of CD80 in p53 responsive cancer cells.
Abstract translation: 本发明涉及用于治疗和确定癌症治疗方式或癌症预后的方法和相关产品。 优选地,所述方法与p53反应性癌细胞中CD80的诱导有关。
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公开(公告)号:US20150150892A1
公开(公告)日:2015-06-04
申请号:US14405985
申请日:2013-06-07
Applicant: Massachusetts Institute of Technology
Inventor: Tyler E. Jacks , Wen Xue , Etienne Meylan , Trudy Gale Oliver , David Feldser , Monte Winslow
IPC: A61K31/69 , A61K45/06 , G01N33/574 , C12N15/113 , C12Q1/68 , A61K31/277 , A61K31/713
CPC classification number: A61K31/69 , A61K31/277 , A61K31/713 , A61K45/06 , C12N15/113 , C12N2310/531 , C12Q1/6886 , C12Q2600/158 , G01N33/57423 , G01N2333/4703 , G01N2333/521 , G01N2333/70542 , G01N2333/8121 , G01N2333/91045 , G01N2333/91194 , G01N2333/96433 , A61K2300/00
Abstract: The invention relates to methods and related products for treatment and determining modes of treatment for cancer. Preferably the methods relate to the inhibition of the NF-κB pathway in lung cancer.
Abstract translation: 本发明涉及用于治疗和确定癌症治疗方式的方法和相关产品。 优选地,所述方法涉及肺癌中NF-κB途径的抑制。
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