公开(公告)号：US20160129019A1

公开(公告)日：2016-05-12

申请号：US14808992

申请日：2015-07-24

Applicant: Massachusetts Institute of Technology

Inventor： Bernhardt Levy Trout ,  Patrick S. Doyle ,  Trevor Alan Hatton ,  Allan Stuart Myerson ,  Ying Diao ,  Matthew E. Helgeson

IPC: A61K31/616 ,  A61K31/167 ,  A61K9/14

CPC classification number: A61K31/616 ,  A61K9/14 ,  A61K9/146 ,  A61K31/167 ,  B01D9/00 ,  B82Y5/00

Abstract: The present invention generally relates to compositions, methods, and systems relating to controlled crystallization and/or nucleation of a molecular species. In some embodiments, the crystallization and/or nucleation of the molecular species may be controlled by tuning the surface chemistry and/or the morphology of a crystallization substrate. In some embodiments, the molecular species is a small organic molecule (e.g., pharmaceutically active agent).

Abstract translation: 本发明一般涉及与分子物质的受控结晶和/或成核相关的组合物，方法和系统。 在一些实施方案中，分子种类的结晶和/或成核可以通过调整结晶底物的表面化学性质和/或形态来控制。 在一些实施方案中，分子种类是小的有机分子（例如药物活性剂）。