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    SYSTEMS FOR THE PROCESSING OF COMPOUNDS
    2.
    发明申请
    SYSTEMS FOR THE PROCESSING OF COMPOUNDS 审中-公开

    公开(公告)号：US20170312674A1

    公开(公告)日：2017-11-02

    申请号：US15372124

    申请日：2016-12-07

    Applicant: Massachusetts Institute of Technology

    Inventor： Allan Stuart Myerson ,  Marcus O'Mahony

    IPC: B01D43/00 ,  B01D36/00

    CPC classification number: B01D43/00 ,  B01D36/008 ,  C02F11/121 ,  C02F11/14

    Abstract: The present disclosure is generally related to the separation of liquids from solids and for the recovery of solids and/or liquids from slurries. In some embodiments, liquids are separated from solids by applying a reduced pressure. In some embodiments, slurries are flowed by applying a pressure gradient. In some embodiments, an apparatus is provided that comprises a channel, an inlet, an outlet, and one or more ports. One or more ports may be constructed and arranged to apply a pressure differential and/or a reduced pressure to the channel. Such systems and methods may, in some embodiments, facilitate continuous manufacturing of solid products.

    POLYMER MATRICES FOR CONTROLLING CRYSTALLIZATION
    4.
    发明申请
    POLYMER MATRICES FOR CONTROLLING CRYSTALLIZATION 审中-公开
    用于控制结晶的聚合物矩阵

    公开(公告)号：US20150196489A1

    公开(公告)日：2015-07-16

    申请号：US14575069

    申请日：2014-12-18

    Applicant: Massachusetts Institute of Technology

    Inventor： Huseyin Burak Eral ,  Vilmali Lopez-Mejias ,  Allan Stuart Myerson ,  Bernhardt Levy Trout ,  Patrick S. Doyle ,  Marcus O'Mahony

    IPC: A61K9/14 ,  A61K31/216

    CPC classification number: A61K31/216 ,  A61K9/1617 ,  A61K9/1652

    Abstract: Compositions, methods, and systems for controlling crystallization of an agent are generally described. In some embodiments, an agent is crystallized in the presence of polymer matrices, such as polymer particles. The polymer matrix may influence at least a portion of the crystallization process and/or the resulting composition. In some such embodiments, the polymer matrix allows one or more aspect of the process and/or composition to be controlled and/or altered. For instance, the polymer matrix may act as a crystallization promoter and/or acceptable carriers of the crystallized agent. In certain embodiments, the polymer matrix described herein, can be used with any agent regardless of its chemical and/or physical properties.

    Abstract translation: 通常描述用于控制试剂结晶的组合物，方法和系统。 在一些实施方案中，试剂在聚合物基质如聚合物颗粒存在下结晶。 聚合物基质可能影响结晶过程的至少一部分和/或所得组合物。 在一些这样的实施方案中，聚合物基质允许控制和/或改变方法和/或组合物的一个或多个方面。 例如，聚合物基质可以作为结晶剂的结晶促进剂和/或可接受的载体。 在某些实施方案中，本文所述的聚合物基质可以与任何试剂一起使用，而不管其化学和/或物理性质。

    ELECTROPROCESSING OF ACTIVE PHARMACEUTICAL INGREDIENTS
    5.
    发明申请
    ELECTROPROCESSING OF ACTIVE PHARMACEUTICAL INGREDIENTS 审中-公开
    活性药物成分的电化学研究

    公开(公告)号：US20130295143A1

    公开(公告)日：2013-11-07

    申请号：US13832812

    申请日：2013-03-15

    Applicant: Massachusetts Institute of Technology

    Inventor： Bernhardt Levy Trout ,  Blair Kathryn Brettmann ,  Allan Stuart Myerson

    IPC: A61J3/00

    CPC classification number: A61J3/00 ,  A61K9/2027 ,  A61K9/2095 ,  A61K9/70 ,  D01D5/0069 ,  D01F1/10

    Abstract: Electrospinning of crystalline particles comprising active pharmaceutical ingredients (API) from suspensions yields fibrous compositions comprising the API. The morphology and size of the crystalline particles may be preserved. The particles may be predominantly retained by fibers and distributed throughout the fibrous mesh. Tablet forms of the APIs prepared from the fibrous compositions demonstrate higher dissolution rates than tablets prepared from compacted powders of the APIs.

    Abstract translation: 包含悬浮液的活性药物成分（API）的结晶颗粒的静电纺丝产生包含API的纤维组合物。 可以保留结晶颗粒的形态和尺寸。 颗粒可以主要由纤维保留并分布在整个纤维网中。 由纤维组合物制备的片剂的片剂形式比从API的压实粉末制备的片剂显示更高的溶解速率。

    METHODS AND SYSTEMS FOR CONTINUOUS HETEROGENEOUS CRYSTALLIZATION
    10.
    发明申请
    METHODS AND SYSTEMS FOR CONTINUOUS HETEROGENEOUS CRYSTALLIZATION 审中-公开
    连续异质结晶的方法与系统

    公开(公告)号：US20160279246A1

    公开(公告)日：2016-09-29

    申请号：US15054956

    申请日：2016-02-26

    Applicant: Massachusetts Institute of Technology

    Inventor： Bernhardt Levy Trout ,  Allan Stuart Myerson ,  Siva Rama Krishna Perala ,  Christopher James Testa ,  Keith Dale Jensen

    IPC: A61K47/26 ,  A61K31/167

    CPC classification number: A61K47/26 ,  A61K31/167 ,  B01D9/0036 ,  B01D9/0059

    Abstract: Methods of heterogeneous crystallization and related systems are provided. In some embodiments, a method comprises crystallizing an agent in a suspension comprising a heteronucleant and the dissolved agent. Crystallization may occur on the surface of the heteronucleant with little or no bulk crystallization and/or secondary nucleation. In some embodiments, a crystallizer may be configured to inhibit secondary nucleation and/or bulk crystallization, for example, by reducing the formation of free crystals that may serve as nucleation surfaces while allowing for adequate mass and heat transfer. In some such embodiments, the crystallizer may be designed to flow (e.g., continuously) a suspension comprising a heteronucleant and an agent in a fluidized state. The methods and systems of the present invention may be used in a wide variety of applications, including the crystallization of pharmaceutically active agents.

    Abstract translation: 提供了异相结晶和相关系统的方法。 在一些实施方案中，一种方法包括使包含异源核苷酸和溶解试剂的悬浮液中的试剂结晶。 结晶可能发生在异源核的表面上，很少或没有本体结晶和/或二次成核。 在一些实施方案中，结晶器可以被配置为抑制二次成核和/或体积结晶，例如通过减少可用作成核表面的自由晶体的形成，同时允许足够的质量和热传递。 在一些这样的实施方案中，结晶器可以被设计成流动（例如，连续地）流态化的包含异源核苷酸和试剂的悬浮液。 本发明的方法和系统可以用于各种应用，包括药物活性剂的结晶。

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