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公开(公告)号：US20190144466A1
公开(公告)日：2019-05-16
申请号：US16167238
申请日：2018-10-22
发明人： Angela N. Koehler , Eric Stefan , Francisco Caballero , Dylan Vijith Neel , Nicholas B. Struntz , Helen L. Evans , Andrew Chen
IPC分类号： C07D498/04 , C07D498/10 , C07D233/28 , C07D491/107
摘要： The present disclosure provides compounds of Formula (I′), Formula (I), Formula (II), Formula (II-A), Formula (III), and Formula (IV). The compounds described herein are MAX binders and/or modulators of Myc, Mad, or Mxi1 (e.g., inhibitors of Myc, Mad, or Mxi1), and may be useful in treating a subject with a disease associated with Myc, such as proliferative diseases (e.g., cancer). Also provided in the present disclosure are pharmaceutical compositions and kits including the compounds described herein, as well as methods of using and uses of the compounds, compositions, and kits.
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公开(公告)号：US20170233405A1
公开(公告)日：2017-08-17
申请号：US15435003
申请日：2017-02-16
发明人： Angela N. Koehler , Eric Stefan , Francisco Caballero , Dylan Vijith Neel , Nicholas B. Struntz , Helen L. Evans , Andrew Chen
IPC分类号： C07D498/04
CPC分类号： C07D498/04 , C07D233/28 , C07D491/107 , C07D498/10
摘要： The present disclosure provides compounds of Formula (I′), Formula (I), Formula (II), Formula (II-A), Formula (III), and Formula (IV). The compounds described herein are MAX binders and/or modulators of Myc, Mad, or Mxi1 (e.g., inhibitors of Myc, Mad, or Mxi1), and may be useful in treating a subject with a disease associated with Myc, such as proliferative diseases (e.g., cancer). Also provided in the present disclosure are pharmaceutical compositions and kits including the compounds described herein, as well as methods of using and uses of the compounds, compositions, and kits.
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公开(公告)号：US10961216B2
公开(公告)日：2021-03-30
申请号：US16198553
申请日：2018-11-21
IPC分类号： C07D401/06 , C07D495/04 , C07D211/46 , A61P35/00 , A61K31/519 , A61K31/445 , A61K31/4545 , A61K45/06 , A61K31/55 , C07D401/12
摘要： Provided herein are compounds useful for modulating the activity of an androgen receptor, or a variant thereof, and related compositions and methods. Compounds of the invention are useful for antagonizing the androgen receptor splice variant AR-v7, and for the treatment of castration-resistant prostate cancer.
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公开(公告)号：US20190202800A1
公开(公告)日：2019-07-04
申请号：US16198553
申请日：2018-11-21
IPC分类号： C07D401/06 , C07D211/46 , C07D401/12 , C07D495/04 , A61P35/00
CPC分类号： C07D401/06 , A61K31/445 , A61K31/4545 , A61K31/519 , A61K31/55 , A61K45/06 , A61P35/00 , C07D211/46 , C07D401/12 , C07D495/04 , A61K2300/00
摘要： Provided herein are compounds useful for modulating the activity of an androgen receptor, or a variant thereof, and related compositions and methods. Compounds of the invention are useful for antagonizing the androgen receptor splice variant AR-v7, and for the treatment of castration-resistant prostate cancer.
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公开(公告)号：US10106555B2
公开(公告)日：2018-10-23
申请号：US15435003
申请日：2017-02-16
发明人： Angela N. Koehler , Eric Stefan , Francisco Caballero , Dylan Vijith Neel , Nicholas B. Struntz , Helen L. Evans , Andrew Chen
IPC分类号： C07D223/28 , C07D491/107 , C07D498/04 , C07D498/10 , C07D233/28
摘要： The present disclosure provides compounds of Formula (I′), Formula (I), Formula (II), Formula (II-A), Formula (III), and Formula (IV). The compounds described herein are MAX binders and/or modulators of Myc, Mad, or Mxi1 (e.g., inhibitors of Myc, Mad, or Mxi1), and may be useful in treating a subject with a disease associated with Myc, such as proliferative diseases (e.g., cancer). Also provided in the present disclosure are pharmaceutical compositions and kits including the compounds described herein, as well as methods of using and uses of the compounds, compositions, and kits.
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