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公开(公告)号：US11964026B2
公开(公告)日：2024-04-23
申请号：US17892496
申请日：2022-08-22
发明人： Antonio Eric Barberio , Santiago Correa Echavarria , Mariane Bandeira Melo , Talar Tokatlian , Erik Christopher Dreaden , Paula T. Hammond , Darrell J. Irvine
CPC分类号： A61K47/6911 , A61K9/0019 , A61K9/1271 , A61K38/208 , A61K47/544 , A61P35/00
摘要： Disclosed are particles for delivering cytokinese, such as IL-12, for the treatment of cancer. The particles comprise cytokines non-covalently bound to liposomes, where the liposomes are coated with polyelectrolytes.
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公开(公告)号：US20210363194A1
公开(公告)日：2021-11-25
申请号：US17255408
申请日：2019-06-05
申请人： International AIDS Vaccine Initiative , The Scripps Research Institute , Massachusetts Institute of Technology
发明人： Talar Tokatlian , Benjamin J. Read , Daniel W. Kulp , Sergey Menis , Jon M. Steichen , William R. Schief , Darrell J. Irvine
摘要： The present invention relates to glycosylate HIV timer nanoparticles fused to self-assembling ferritin proteins which may be utilized as immunogens to enhance trafficking to lymph nodes and germinal centers and to heighten immune responses.
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公开(公告)号：US20230201367A1
公开(公告)日：2023-06-29
申请号：US17892496
申请日：2022-08-22
发明人： Antonio E. Barberio , Santiago Correa Echavarria , Mariane Bandeira Melo , Talar Tokatlian , Erik Christopher Dreaden , Paula T. Hammond , Darrell J. Irvine
CPC分类号： A61K47/6911 , A61K9/0019 , A61K9/1271 , A61K38/208 , A61K47/544 , A61P35/00
摘要： Disclosed are particles for delivering cytokinese, such as IL-12, for the treatment of cancer. The particles comprise cytokines non-covalently bound to liposomes, where the liposomes are coated with polyelectrolytes.
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公开(公告)号：US20190125895A1
公开(公告)日：2019-05-02
申请号：US16175311
申请日：2018-10-30
发明人： Antonio Eric Barberio , Santiago Correa Echavarria , Mariane Bandeira Melo , Talar Tokatlian , Erik Christopher Dreaden , Paula T. Hammond , Darrell J. Irvine
摘要： Disclosed are particles for delivering cytokinese, such as IL-12, for the treatment of cancer. The particles comprise cytokines non-covalently bound to liposomes, where the liposomes are coated with polyelectrolytes.
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公开(公告)号：US11419947B2
公开(公告)日：2022-08-23
申请号：US16175311
申请日：2018-10-30
发明人： Antonio Eric Barberio , Santiago Correa Echavarria , Mariane Bandeira Melo , Talar Tokatlian , Erik Christopher Dreaden , Paula T. Hammond , Darrell J. Irvine
摘要： Disclosed are particles for delivering cytokinese, such as IL-12, for the treatment of cancer. The particles comprise cytokines non-covalently bound to liposomes, where the liposomes are coated with polyelectrolytes.
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