公开(公告)号：US08733154B2

公开(公告)日：2014-05-27

申请号：US13851834

申请日：2013-03-27

Applicant: Matrix Sensors, Inc.

Inventor： Michael D. Cable ,  Matthias Steiert

IPC: G01N29/24

CPC classification number: G01N29/036 ,  G01N29/2406 ,  G01N2291/0255 ,  G01N2291/0256

Abstract: A method for analyzing liquid samples may comprise applying a liquid to a cMUT device having a plurality of sensors, drying the plurality of sensors, electronically detecting an agent bound to each of the plurality of sensors, wherein the electrical circuit provides a sensor output responsive to a mechanical resonance frequency of the sensor, wherein the mechanical resonance frequency of the sensor is responsive to the binding of an agent to the functionalized membrane, and determining the mass of the agent bound to each of the plurality of sensors.

Abstract translation: 用于分析液体样品的方法可以包括向具有多个传感器的cMUT装置施加液体，干燥多个传感器，电子地检测绑定到多个传感器中的每一个的试剂，其中电路提供响应于 传感器的机械共振频率，其中传感器的机械共振频率响应于试剂与功能化膜的结合，以及确定结合到多个传感器中的每一个的试剂的质量。

公开(公告)号：US20150011428A1

公开(公告)日：2015-01-08

申请号：US14322756

申请日：2014-07-02

Applicant: MATRIX SENSORS, INC.

Inventor： Michael D. Cable ,  Heinrich Sussner ,  Steven Yamamoto

IPC: G01N29/02 ,  G01N33/00 ,  G01N27/22 ,  G01N33/543

CPC classification number: G01N29/2406 ,  B05D1/005 ,  G01N29/022 ,  G01N29/028 ,  G01N29/036 ,  G01N33/0031 ,  G01N33/54393 ,  G01N33/552 ,  G01N33/553 ,  G01N2291/014 ,  G01N2291/018 ,  G01N2291/021 ,  G01N2291/022 ,  G01N2291/0427 ,  G01N2291/106

Abstract: Surface modifications to sensors in an array give the sensors different functionalities for adsorbing or binding molecules. A first sensor in the array includes a first resonating member having a first surface comprising a polymer receptor material coated over a first underlying material. A second sensor includes a second resonating member having a second surface comprising the polymer receptor material coated over a second underlying material that is different than the first underlying material. The first underlying material, the second underlying material, and the polymer receptor material are selected such that the first resonating member, having a combination of the polymer receptor material and the first underlying material, has a different ability to adsorb or bind a mass of one or more analytes than does the second resonating member having a combination of the polymer receptor material with the second underlying material. Methods for fabricating sensors with surface modifications are also provided.

Abstract translation: 对阵列中的传感器的表面改性给传感器提供了吸附或结合分子的不同功能。 阵列中的第一传感器包括第一谐振构件，其具有包含涂覆在第一下层材料上的聚合物受体材料的第一表面。 第二传感器包括具有第二表面的第二谐振元件，该第二表面包括聚合物受体材料，所述第二表面涂覆在不同于第一底层材料的第二底层材料上。 选择第一基础材料，第二基础材料和聚合物受体材料，使得具有聚合物受体材料和第一下面材料的组合的第一谐振构件具有不同的吸附或粘合一个物质的能力 或更多的分析物比具有聚合物受体材料与第二下面材料的组合的第二共振构件相同。 还提供了用于制造具有表面改性的传感器的方法。