公开(公告)号：US20220001414A1

公开(公告)日：2022-01-06

申请号：US17476469

申请日：2021-09-15

申请人： MATRIX SENSORS, INC.

发明人： David K. Britt ,  Paul R. Wilkinson ,  Steven Yamamoto

IPC分类号： B05C5/00 ,  B05C5/02 ,  B05C13/02 ,  B05C11/10 ,  B05C15/00

摘要： A method is provided for coating a surface of a material with a film of porous coordination polymer. A first substrate having a first surface to be coated is positioned in a processing chamber such that the first surface is placed in an opposing relationship to a second surface. The second surface may be provided by a wall of the processing chamber, or in some cases the second surface may be provided by a second substrate to be coated. The first substrate is held such that a gap exists between the first and second surfaces, and the gap is filled with at least one reaction mixture comprising reagents sufficient to form the crystalline film on at least the first surface. A thin gap (e.g., less than 2 mm) between the first and second surfaces is effective for producing a high quality film having a thickness less than 100 μm. Confining the volume of the reaction mixture to a thin layer adjacent the substrate surface significantly reduces problems with sedimentation and concentration control. The size, shape, or average thickness of the gap may be adjusted during formation of the film in response to feedback from at least one film growth monitor.

公开(公告)号：US20210387161A1

公开(公告)日：2021-12-16

申请号：US17458556

申请日：2021-08-27

申请人： Matrix Sensors, Inc.

发明人： David K. Britt ,  Paul R. Wilkinson ,  Steven Yamamoto

IPC分类号： B01J20/22 ,  B05C11/10

摘要： An apparatus and method is provided for coating a surface of a substrate with at least one film of porous coordination polymer. A body has an interior space for holding the substrate to be coated, at least one inlet, and at least one outlet in communication with the interior space to permit fluid to flow in a downstream direction from the inlet, across the surface of the substrate in the interior space, and through the outlet. A plurality of flow channels are arranged to flow a plurality of different reagent solutions from respective supply sources to the at least one inlet. The flow channels merge into at least one mixing region, positioned upstream of the interior space, to mix the solutions prior to the mixture contacting the surface of the substrate in the interior space. At least one pressure source and valve system are arranged with the supply sources and the flow channels to select at least one combination of the reagent solutions to be mixed and to force the selected reagent solutions to flow from their respective supply sources, through the flow channels, and into the mixing region at different, independently controllable flow rates to regulate respective concentrations of reagents in the mixture.

公开(公告)号：US20140364325A1

公开(公告)日：2014-12-11

申请号：US13911003

申请日：2013-06-05

申请人： MATRIX SENSORS, INC.

发明人： Michael D Cable ,  Heinrich Sussner

IPC分类号： G01N33/50

CPC分类号： G01N33/5438 ,  G01N29/022 ,  G01N29/036 ,  G01N29/222 ,  G01N29/2406 ,  G01N33/0031 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/0427 ,  G01N2291/106

摘要： A sensor array includes resonator sensors having respective receptor materials disposed thereon. The receptor materials have a physical property relevant to their ability to bind or adsorb one or more analytes in a sample. The physical property of the receptor materials on the sensors systematically increases or decreases in degree from one sensor to the next in the array. The device also comprises at least one detector for detecting sensor responses when masses of the analytes are adsorbed or bound to the receptor materials on the sensors. With this graded panel of sensors in the array, the analytes may adsorb or bind to the functionalized sensors with a pattern of responses specific to each analyte.

摘要翻译： 传感器阵列包括其上设置有各自的受体材料的谐振器传感器。 受体材料具有与其结合或吸附样品中一种或多种分析物的能力相关的物理性质。 传感器上的受体材料的物理性质系统地从阵列中的一个传感器到下一个传感器的程度增加或减少。 该装置还包括至少一个检测器，用于当大量分析物被吸附或结合到传感器上的受体材料时检测传感器响应。 通过阵列中的这种分级传感器，分析物可以以特定于每种分析物的响应模式吸附或结合功能化传感器。

公开(公告)号：US08733154B2

公开(公告)日：2014-05-27

申请号：US13851834

申请日：2013-03-27

申请人： Matrix Sensors, Inc.

发明人： Michael D. Cable ,  Matthias Steiert

IPC分类号： G01N29/24

CPC分类号： G01N29/036 ,  G01N29/2406 ,  G01N2291/0255 ,  G01N2291/0256

摘要： A method for analyzing liquid samples may comprise applying a liquid to a cMUT device having a plurality of sensors, drying the plurality of sensors, electronically detecting an agent bound to each of the plurality of sensors, wherein the electrical circuit provides a sensor output responsive to a mechanical resonance frequency of the sensor, wherein the mechanical resonance frequency of the sensor is responsive to the binding of an agent to the functionalized membrane, and determining the mass of the agent bound to each of the plurality of sensors.

摘要翻译： 用于分析液体样品的方法可以包括向具有多个传感器的cMUT装置施加液体，干燥多个传感器，电子地检测绑定到多个传感器中的每一个的试剂，其中电路提供响应于 传感器的机械共振频率，其中传感器的机械共振频率响应于试剂与功能化膜的结合，以及确定结合到多个传感器中的每一个的试剂的质量。

公开(公告)号：US20210285126A1

公开(公告)日：2021-09-16

申请号：US17198204

申请日：2021-03-10

申请人： MATRIX SENSORS, INC.

发明人： David K. Britt ,  Paul R. Wilkinson ,  Steven Yamamoto

IPC分类号： C30B28/04 ,  C08J5/18 ,  C07F9/00 ,  G01G3/16 ,  C30B29/58 ,  C07F15/04

摘要： An apparatus and method is provided for coating a surface of a material with a film of porous coordination polymer. A first substrate having a first surface to be coated is positioned in a processing chamber such that the first surface is placed in a substantially opposing relationship to a second surface. In some embodiments, the second surface is provided by a wall of the processing chamber, and in other embodiments the second surface is provided by a second substrate to be coated. The first substrate is held such that a gap exists between the first and second surfaces, and the gap is filled with at least one reaction mixture comprising reagents sufficient to form the crystalline film on at least the first surface. A thin gap (e.g., having a thickness less than 2 mm) between the first and second surfaces is effective for producing a high quality film having a thickness less than 100 μm. Confining the volume of the reaction mixture to a thin layer adjacent the substrate surface significantly reduces problems with sedimentation and concentration control. In some embodiments, the size, shape, or average thickness of the gap is adjusted during formation of the film in response to feedback from at least one film growth monitor.

公开(公告)号：US20180202961A1

公开(公告)日：2018-07-19

申请号：US15872999

申请日：2018-01-17

申请人： MATRIX SENSORS, INC.

发明人： Heinrich Sussner ,  Paul R. Wilkinson ,  Steven Yamamoto ,  David K. Britt

IPC分类号： G01N27/327 ,  G01N27/02 ,  A61B5/055

CPC分类号： G01N27/3271 ,  A61B5/055 ,  A61B5/14503 ,  A61B5/14546 ,  A61B5/686 ,  A61B2562/028 ,  A61B2562/029 ,  B81B2201/06 ,  G01N27/026 ,  G01N29/00 ,  G01N29/022 ,  G01N29/036 ,  G01N29/2406 ,  G01N29/4427 ,  G01N2291/0256 ,  G01N2291/02809 ,  G01N2291/02845 ,  G01N2291/0426 ,  G01N2291/0427

摘要： A device and method are provided for detecting analyte with correction for the effects of humidity. The device comprises a resonant sensor having an oscillating portion. A capacitor is positioned on the oscillating portion. The capacitor is formed by at least two electrodes and a sensing material positioned between the electrodes. A readout circuit is arranged to measure a response of the oscillating portion (e.g., frequency shift or change in resonance frequency, stiffness or strain) and a capacitance of the capacitor when substances are adsorbed or absorbed in the sensing material. This combination of measurements enables the device to distinguish between various types of adsorbed or absorbed molecules, especially distinguishing between an analyte of interest and water molecules that might interfere with the detection of the analyte. A processor determines an analyte value indicative of the presence, amount or concentration of the analyte in dependence upon measurements of both the response of the oscillating portion and the capacitance to account for the effects of water in the sensing material.

公开(公告)号：US10605778B2

公开(公告)日：2020-03-31

申请号：US16118159

申请日：2018-08-30

申请人： MATRIX SENSORS, INC.

发明人： David K Britt ,  Paul R Wilkinson ,  Steven Yamamoto

IPC分类号： G01N29/02 ,  G01N29/036 ,  G01N29/32 ,  G01N33/00 ,  G01N29/22

摘要： A gas sensor comprises at least one transducer and a sensing material (e.g., a metal-organic framework) disposed on the transducer. The sensing material has a temperature-dependent gas sorption behavior. A detector is arranged to detect responses of the transducer to sorption and/or desorption of a target gas in the sensing material and to output transducer measurement signals indicative of the transducer responses. At least one thermal element changes the temperature of the sensing material by heating and/or cooling, and at least one temperature sensor (which may be integral with the thermal element) is arranged to measure a temperature of the sensing material. At least one processor determines the quantity (e.g., concentration, partial pressure, or mass) of the target gas according to the temperature of the sensing material at which the transducer measurement signals satisfy a signal value condition.

公开(公告)号：US20170173623A1

公开(公告)日：2017-06-22

申请号：US15383548

申请日：2016-12-19

申请人： MATRIX SENSORS, INC.

发明人： David K. Britt ,  Paul R Wilkinson ,  Steven Yamamoto

IPC分类号： B05C9/02 ,  B05C21/00 ,  B05D1/30 ,  B05D1/34 ,  B05D7/14 ,  B05C9/10 ,  B05C9/14

CPC分类号： B01J20/226

摘要： An apparatus and method is provided for coating a surface of a material with at least one film of porous coordination polymer. A body (e.g., a flow cell) has an interior space for holding the material to be coated, at least one inlet, and at least one outlet in communication with the interior space to permit fluid to flow in a downstream direction from the inlet, across the surface of the material in the interior space, and through the outlet. A plurality of flow channels are arranged to flow a plurality of different reagent solutions from respective supply sources to the at least one inlet. The flow channels merge into at least one mixing region, positioned upstream of the interior space, to mix the solutions prior to the mixture contacting the surface of the material in the interior space. At least one pressure source and valve system are arranged with the supply sources and the flow channels to select at least one combination of the reagent solutions to be mixed and to force the selected reagent solutions to flow from their respective supply sources, through the flow channels, and into the mixing region at independently controllable flow rates to regulate respective concentrations of reagents in the mixture.

公开(公告)号：US09366651B2

公开(公告)日：2016-06-14

申请号：US14322756

申请日：2014-07-02

申请人： MATRIX SENSORS, INC.

发明人： Michael D Cable ,  Heinrich Sussner ,  Steven Yamamoto

IPC分类号： G01N15/06 ,  G01N33/00 ,  G01N33/48 ,  G01N29/02 ,  G01N29/028 ,  G01N29/036 ,  G01N29/24

CPC分类号： G01N29/2406 ,  B05D1/005 ,  G01N29/022 ,  G01N29/028 ,  G01N29/036 ,  G01N33/0031 ,  G01N33/54393 ,  G01N33/552 ,  G01N33/553 ,  G01N2291/014 ,  G01N2291/018 ,  G01N2291/021 ,  G01N2291/022 ,  G01N2291/0427 ,  G01N2291/106

摘要： Surface modifications to sensors in an array give the sensors different functionalities for adsorbing or binding molecules. A first sensor in the array includes a first resonating member having a first surface comprising a receptor material coated over a first underlying material. A second sensor includes a second resonating member having a second surface comprising the receptor material coated over a second underlying material that is different than the first underlying material. The first underlying material, the second underlying material, and the receptor material are selected such that the first resonating member, having a combination of the receptor material and the first underlying material, has a different ability to adsorb or bind a mass of one or more analytes than does the second resonating member having a combination of the receptor material with the second underlying material. Methods for fabricating sensors with surface modifications are also provided.

摘要翻译： 对阵列中的传感器的表面改性给传感器提供了吸附或结合分子的不同功能。 阵列中的第一传感器包括具有第一表面的第一谐振元件，第一谐振元件包括涂覆在第一底层材料上的受体材料。 第二传感器包括具有第二表面的第二谐振元件，该第二表面包括被覆在不同于第一基础材料的第二下层材料上的受体材料。 选择第一基础材料，第二基础材料和受体材料，使得具有受体材料和第一下面材料的组合的第一谐振构件具有不同的吸附或结合一个或多个 分析物比具有受体材料与第二下面材料的组合的第二共振构件相同。 还提供了用于制造具有表面改性的传感器的方法。

公开(公告)号：US20150011428A1

公开(公告)日：2015-01-08

申请号：US14322756

申请日：2014-07-02

申请人： MATRIX SENSORS, INC.

发明人： Michael D. Cable ,  Heinrich Sussner ,  Steven Yamamoto

IPC分类号： G01N29/02 ,  G01N33/00 ,  G01N27/22 ,  G01N33/543

CPC分类号： G01N29/2406 ,  B05D1/005 ,  G01N29/022 ,  G01N29/028 ,  G01N29/036 ,  G01N33/0031 ,  G01N33/54393 ,  G01N33/552 ,  G01N33/553 ,  G01N2291/014 ,  G01N2291/018 ,  G01N2291/021 ,  G01N2291/022 ,  G01N2291/0427 ,  G01N2291/106

摘要： Surface modifications to sensors in an array give the sensors different functionalities for adsorbing or binding molecules. A first sensor in the array includes a first resonating member having a first surface comprising a polymer receptor material coated over a first underlying material. A second sensor includes a second resonating member having a second surface comprising the polymer receptor material coated over a second underlying material that is different than the first underlying material. The first underlying material, the second underlying material, and the polymer receptor material are selected such that the first resonating member, having a combination of the polymer receptor material and the first underlying material, has a different ability to adsorb or bind a mass of one or more analytes than does the second resonating member having a combination of the polymer receptor material with the second underlying material. Methods for fabricating sensors with surface modifications are also provided.

摘要翻译： 对阵列中的传感器的表面改性给传感器提供了吸附或结合分子的不同功能。 阵列中的第一传感器包括第一谐振构件，其具有包含涂覆在第一下层材料上的聚合物受体材料的第一表面。 第二传感器包括具有第二表面的第二谐振元件，该第二表面包括聚合物受体材料，所述第二表面涂覆在不同于第一底层材料的第二底层材料上。 选择第一基础材料，第二基础材料和聚合物受体材料，使得具有聚合物受体材料和第一下面材料的组合的第一谐振构件具有不同的吸附或粘合一个物质的能力 或更多的分析物比具有聚合物受体材料与第二下面材料的组合的第二共振构件相同。 还提供了用于制造具有表面改性的传感器的方法。