公开(公告)号：US20090162393A1

公开(公告)日：2009-06-25

申请号：US11906440

申请日：2007-10-01

申请人： Matt Cook ,  Nick Elliot ,  Jawahar Patil ,  Barbara Nowak ,  Michael Attard ,  Phil Crosbie ,  Richard Morrison ,  Giles Campbell ,  Bronwyn Holmes ,  Christopher Prideaux

发明人： Matt Cook ,  Nick Elliot ,  Jawahar Patil ,  Barbara Nowak ,  Michael Attard ,  Phil Crosbie ,  Richard Morrison ,  Giles Campbell ,  Bronwyn Holmes ,  Christopher Prideaux

IPC分类号： A61K39/00

CPC分类号： A61K39/002 ,  A61K2039/53 ,  A61K2039/55 ,  G01N33/56905

摘要： The present invention provides a vaccine composition including a nucleic acid that encodes an amoeba-derived antigen (or a peptide molecule encoded thereby), or fragments or variants thereof. The present invention also provides for the use of such vaccine compositions in eliciting an immune response and/or protective immunity in a host against amoebic infection and screening a sample for the presence of amoebae.

摘要翻译： 本发明提供一种疫苗组合物，其包含编码来自阿米巴的抗原（或由其编码的肽分子）或其片段或变体的核酸。 本发明还提供了这样的疫苗组合物在宿主中引发免疫应答和/或保护性免疫以抗阿米巴感染并筛选样品以存在变形虫素的用途。

公开(公告)号：US06673222B1

公开(公告)日：2004-01-06

申请号：US09809108

申请日：2001-03-16

申请人： Sadaksharasundaram S. Papavinasam ,  William D. Gould ,  Robert W. Revie ,  Fraser A. MacLeod ,  Michael Attard

发明人： Sadaksharasundaram S. Papavinasam ,  William D. Gould ,  Robert W. Revie ,  Fraser A. MacLeod ,  Michael Attard

IPC分类号： G01N27327

CPC分类号： C12Q1/005 ,  C12Q1/04 ,  G01N2333/90212

摘要： A biological activity probe for the detection on-line of the presence of sulphide including an enzyme electrode; a counter electrode; a reference electrode; and if desired a corrosion electrode. The enzyme electrode includes an immobilised source of sulfide oxidase enzyme, together with a cofactor such as 1,1′-dimethylferrocene, immobilised in a water permeable non-conducting binder on a biologically inert electrically conducting substrate. The immobilised source of sulfide oxidase enzyme is either a chemoautotropic microorganism such as a Thiobacillus thioparus, or enzyme material recovered from a culture of a Thiobacillus thioparus. The probe when connected to a suitable electrical system is capable of identifying microbiological activity resulting in microbiologically influenced corrosion; microbiological activity not resulting in microbiologically influenced corrosion; microbiological inactivity, coupled with non-microbiologically influenced corrosion; and microbiological inactivity; and no corrosion.

摘要翻译： 用于在线检测包括酶电极的硫化物存在的生物活性探针; 对电极 参考电极; 并且如果需要，腐蚀电极。 酶电极包括固定在生物惰性导电基底上的透水非导电粘合剂中的硫化物氧化酶的固定源和辅助因子如1,1'-二甲基二茂铁。 硫化物氧化酶的固定化源是化学自旋性微生物，例如硫代硫杆菌（Thiobacillus thioparus）或从硫杆菌硫代硫杆菌培养物中回收的酶物质。 连接到合适的电气系统时的探头能够识别导致微生物影响的腐蚀的微生物活性; 微生物活性不会导致微生物影响的腐蚀; 微生物不活动，加上非微生物学影响的腐蚀; 和微生物不活动; 无腐蚀。